Conserved Protein Domain Family
Neogenin_C

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pfam06583: Neogenin_C 
Neogenin C-terminus
This family represents the C-terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites. Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of pfam00047 and pfam00041) and is closely related to the DCC tumor suppressor gene product - these proteins may play an integral role in regulating differentiation programmes and/or cell migration events within many adult and embryonic tissues.
Statistics
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PSSM-Id: 399527
View PSSM: pfam06583
Aligned: 13 rows
Threshold Bit Score: 247.137
Threshold Setting Gi: 328718304
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFN77478     1139 IKPPDLWIHHDQMELKALEKS---SLNGEASTSGVTSNTLPRSGNSEYNQdNVHGNSSsldkrtyvpSYMGN-------T 1208 Jerdon's jump...
EFN70853     1145 IKPPDLWIHHDQMELKALEKS---SLNGEPSTSGVTSNTLPRSSNLEYNQdNVHGNSSsldkrtyvpSYMGN-------T 1214 Florida carpe...
EGI70449     1169 IKPPDLWIHHDQMELKALEKS---SLNGEASTSGVTSNTLPRSGNQEYNQdNIHGNSSsldkrtyvpSYMGN-------T 1238 Panamanian le...
EEB12791     1113 MKPPDLWIHHDQMELKALEKShhsNSDIGPSSSGSQMNTLGRNGSGQTTN-DVVDHTNsldkrtylpSYVGGsgc-tvdQ 1190 human body louse
XP_003246447 1135 IKPPDLWIHHDQMELKSMEKSsqgSLD-TSSGCGQGSSNTYDGPDTRVTIhHVPQATNsleksnyvsSYVGNtimkpllS 1213 pea aphid
Q90610       1143 VKPPDLWIHHERLELKPIDKSpdpNPIMTDTPIPRNSQDITPVDNSMDSN--IHQRRN---------SYRGHe------S 1205 chicken
NP_775325    1135 LKPPDLWIHHERLELKPIDKSpepNPVMTDTPIPRTSQDITPVDGSMDP---MLQRRN---------SYRGHe------S 1196 zebrafish
XP_015199138 1145 LKPPDLWIHHERLELKPIDKSpepNPVMTDTPIPRTSQDITPVDSAADNT--IHQRRS---------SCRGHe------S 1207 spotted gar
3_pfamImport    1 LRPPDLWIHHEEMEMKNMEKApsvAPSGHDSPL-QSCQDLPQVAHSQSES-HMGSKS----------SHSGAd------G 62  
CAG06234      337 LRPPDLWIHHEEMEMKNMEKApsvAPSGHDSPI-QSCQDLPQVAHSQSES-QIGSKS----------SHSGGd------G 398  spotted green...
XP_022524542 1127 LRPPDLWIHHEEMELKNIEKPsssAPSGRESPI-QSCQEIAPVSHSQSES-QMGSKS----------SHSGGd------A 1188 Mexican tetra
XP_012657451 1032 LRPPDLWIHHEEMEMKNIEKPsgtDPAGRDSPI-QSCQDLTPVSHSQSET-QLGSKST---------SHSGQd------T 1094 small-eared g...
XP_012821604 1123 VKPPDLWIHHERLELKPTDKSpetNPILTDTPLPRSPQDLTPGDSTTESS--IHQHSN---------SYRGLe------S 1185 tropical claw...
EFN77478     1209 DEKCS-------TLSRQhsrGSHKPKlISLPVDSAPLHQPIATATPIVNTSMSQptihsscsdtssvrqnyprtvaQYsl 1281 Jerdon's jump...
EFN70853     1215 DEKCS-------TLSRQhsrGSHKPKlITLPVDSTPLHQPIATATPIVNTSMSQptihtscsdtssvrqnyprtvaQYsl 1287 Florida carpe...
EGI70449     1239 DEKCS-------TLSRQhsrGSHKSKlITLPIDSAPLHQPIATATPIVNSSMSQptihtscsdtssvrqnyprtvaQYsl 1311 Panamanian le...
EEB12791     1191 QEKTS-------TIKRT----VIKPKpISLPMETQPIAQP----------VMTNgtpltqspgs--elgrplyprtQYr- 1246 human body louse
XP_003246447 1214 DEKVS-------TLKNR-----FKPKsVVLPVDSFD--------------SVYNdtmatlpnq----esrsphpksQYat 1263 pea aphid
Q90610       1206 EDSMS-------TLAGR---RGMRPK-MMMPFDSQP-PQPVISAHPIHSLDNPH----------------------HH-- 1249 chicken
NP_775325    1197 EDSMS-------TLAGR---RGMRPK-MMMPFDAQP-PQPVISAHPIHSLDNHH----------------------HH-- 1240 zebrafish
XP_015199138 1208 EDSMS-------TLAGR---RGMRPK-MMMPFDAQP-PQPVISAHPIHSLDNHH----------------------HH-- 1251 spotted gar
3_pfamImport   63 DEASSsistldrSLAGR---RGTRGK-MMIPMDSQPSNTPVVSAIPVPAMDSS-----------------------QY-- 113 
CAG06234      399 DEASSsistlerSLAAR---RGTRSK-MMIPMDTQPSNTPVVSAIPVPALDSS-----------------------QY-- 449  spotted green...
XP_022524542 1189 DEASSsistlerSLAAR---RATRTK-MMIPMDSQPSNTPVVSAIPVPTLESS-----------------------QY-- 1239 Mexican tetra
XP_012657451 1095 EEAGSsmstlerSLAAR---RATRAK-LMIPMDAQSSNPAVVSAIPVPTLESA-----------------------QY-- 1145 small-eared g...
XP_012821604 1186 EDSVS-------SLAGR---RGMRPK-IMMPFDSQP-PQPVVSAHPIHSHDNSH----------------------HFrs 1231 tropical claw...
EFN77478     1282 -srAHVTLEPT---PESS-------------------PDSCN----IP---------NSYE--PLQSQLSYGTSGQSYSG 1323 Jerdon's jump...
EFN70853     1288 -nrAHVTLEPT---PESS-------------------PDSCN----MP---------SSYE--PLQSQLSYGTSGQSYSG 1329 Florida carpe...
EGI70449     1312 -nrAHVTLEPT---PESS-------------------PDSC-----IP---------SSYE--PLQNQLSYGTSGQSYSG 1352 Panamanian le...
EEB12791     1247 ---AHITLDST---TSGTglenpyslqsgydsigtltPTASI----LPn-------aNTYSqnPLTSQTAMQPSLAS--- 1306 human body louse
XP_003246447 1264 ttrAHVTVDLTagaPENNy-----------------iVQATT----VP---------DKFEsiPVSSAANLQQQHTALLN 1313 pea aphid
Q90610       1250 ---FHSGSLAS---PTRSylhhqvsp----wpvgtsmSHSDR----ANs-------tESVRntPSSDTMPASSSQPCAD- 1307 chicken
NP_775325    1241 ---YHLGSLAS---PTRSylhhqsst----rsiatpiSHLDR----AEs-------tESVRntPNAELLPPSGQPSCTTD 1299 zebrafish
XP_015199138 1252 ---YHSGSLAS---PTRShlhhqinp----rplatpiSHVDR----AHs-------aESVRntPSADPLPVPVQPACAVD 1310 spotted gar
3_pfamImport  114 -----PGILPS---PSCGfthnkfslr-pmpfpsltvDRGYT----PGy-------sSSGGtgLAVQKVTSHLTSYQKHS 173 
CAG06234      450 -----SGILPS---PSCGfthnkfslr-pmpfstltvDRGYTpehvPVv-------------sPVPGAPAPVVPAPAE-- 505  spotted green...
XP_022524542 1240 -----PGILPS---PTCGytphtkf-----tlrpmpfSTLTV----DRsyasamaaeGAAPlgP-QQQPTLIPTVQSEPS 1301 Mexican tetra
XP_012657451 1146 -----PGILPS---PTCGyphpqftlr-pvpfptlsvDRGFG----AGr-------sQSVSegPTTQQPPMLPPSQPEHP 1205 small-eared g...
XP_012821604 1232 vpgFMLHVLGG---PPQAa--------------------------------------ESVRhtPSCDTVVAASSSSQTG- 1269 tropical claw...
EFN77478     1324 NaqyapghygnssqpMSSnTVGVESNSS----KRLQGHPLKSFSVPAPPPQSA--------PSTPAQQKHgvsq------ 1385 Jerdon's jump...
EFN70853     1330 Stqyapgh-yggsnqPMSnTVGMESNNS----KRLQGHPLKSFSVPAPPPQSA--------PSTPAQQKHgvsq------ 1390 Florida carpe...
EGI70449     1353 Ntqyasgh-ygnntqPVSsAVG-ENNTS----KRLQGHPLKSFSVPAPPPQSA--------PSTPAQQKHgvsh------ 1412 Panamanian le...
EEB12791     1307 -----------------SnMTNIDNNGTl--gKRQQGHPLKSFSVPAPPPQSA--------PSTP-QQKHv--------- 1349 human body louse
XP_003246447 1314 S--------------SE---------------KRQQGHPLKSFSVPAPPPQSA--------PSTP-QQKHiv-------- 1347 pea aphid
Q90610       1308 Hqdpds----ssgayLGS-AQEEDAAQSlptaHVRPSHPLKSFAVPAVPAAGSayd--ptlPSTPLLTQQ---------- 1370 chicken
NP_775325    1300 Lsetd-------isfHSS-AAEEEPAFAtptaHVRPTHPLKSFAVPAIPAHAMyds--aalPSTPLLSQT---------- 1359 zebrafish
XP_015199138 1311 Hpepds-----gasfLSS-APEEESYNPpt-aHVRPTHPLKSFAVPAVPTPGTsfes-palPSTPLLTQT---------- 1372 spotted gar
3_pfamImport  174 ----------------R--LISRPPATViptiVILLPHKILIFTDYLITPIKSeiy---prdFCQVEPAA---------- 222 
CAG06234      506 -------------------EAQGAGGRSiptaCVRPTHPLRSFTNPLLPSSMGtid---pkvYTSMMPQStpgeafavei 563  spotted green...
XP_022524542 1302 -------------------GSEEIPSRTiptaCVRPSHPMRSFTNPLLPPPMGtie---pkvYTPMMPQT---------- 1349 Mexican tetra
XP_012657451 1206 -------------------SSEEAPSRTiptaCVRPTHPLRSFANPLLPPPMSaie--pkvPYTPLLSQP---------- 1254 small-eared g...
XP_012821604 1270 Pedpdp----sgvsfLPG-SLDEDSVPSvptaHIRPSHPLKSFAVPAVPTSASgasyepslPSSPLLQQQ---------- 1334 tropical claw...
EFN77478     1386 -----------------------vtvRPTMSGSPYKKpp------qsSSSQLaAKNRL----ASVSNTAHTSEE-VERL- 1430 Jerdon's jump...
EFN70853     1391 -----------------------vtvRPTMSGSPYKKpq-------sSSSQL-AKNRL----ASVSNPTHTSEE-VERL- 1433 Florida carpe...
EGI70449     1413 -----------------------vtvRPTMSGSPYKKsq-------gSSSQL-TKNRL----ASVSNPAHTSEE-VERL- 1455 Panamanian le...
EEB12791     1350 -------------------------vRPLQSSSPYKKvglhgimgtcSPSN-----------SKLRSGPGTIEE-TTRL- 1391 human body louse
XP_003246447 1348 ------------------------tvRPQGSSSPYKKniysainsspSSTSVsTGPKTwkspLTGSNQRDTITE-VESLn 1402 pea aphid
Q90610       1371 --------------------------APSHPVHSVKT----------ASIGTlGRTRPpm-pVVVPSAPDVQE--TTRMl 1411 chicken
NP_775325    1360 --------------------------GP----HSVKT----------ASIGTlGRTRTpm-pVIVPNAPDVSE--GCRLh 1396 zebrafish
XP_015199138 1373 --------------------------GPASQVHSVKT----------ASIGTlGRTRSpm-pVIVPSAPDVPE--TSKMl 1413 spotted gar
3_pfamImport  223 ----------------------------SLSKPQVKT----------ASLGQaGKARSpllpVSVPTAPDVSEEgGTKPa 264 
CAG06234      564 mrlwqrnphssfftlsatdpcftngsGASLPKPQVKT----------ASLGQpGKARSpllpVSVPTAPDLTEE-AAKAa 632  spotted green...
XP_022524542 1350 --------------------------GGSLPKPQVKT----------ASLGQaGKARSpllpVSVPTAPETAEE-GQKPp 1392 Mexican tetra
XP_012657451 1255 --------------------------GPTLPKTHVKT----------ASLGLaGKARSpllpVSVPTAPEVSEE-SHKPt 1297 small-eared g...
XP_012821604 1335 --------------------------CPTA--LSVKT----------ASLGTlGRVRPpl-pVTVPSAPEPLE--TSRMl 1373 tropical claw...
EFN77478     1431 ----KP--------------------------------------SYSTEELNQEMANLEGLMKDLNAITAS 1459 Jerdon's jumping ant
EFN70853     1434 ----KP--------------------------------------SYSTEELNQEMANLEGLMKDLNAITAS 1462 Florida carpenter ant
EGI70449     1456 ----KP--------------------------------------SYSTEELNQEMANLEGLMKDLNAITAS 1484 Panamanian leafcutter ant
EEB12791     1392 ----QP--------------------------------------SYSTEELNQEMANLEGLMKDLNAITAS 1420 human body louse
XP_003246447 1403 k--iQT--------------------------------------SYSTEELNQEMANLEGLMKDLSAITAS 1433 pea aphid
Q90610       1412 e-dsES--------------------------------------SYEPDELTKEMAHLEGLMKDLNAITTA 1443 chicken
NP_775325    1397 e-daGS--------------------------------------NYETDELSEEMAHLEGLMKDLNAITTA 1428 zebrafish
XP_015199138 1414 e-dvES--------------------------------------NYEADELSEEMAHLEGLMKDLNAITTA 1445 spotted gar
3_pfamImport  265 edsaAN--------------------------------------IYEQDDLSEQMASLEGLMKQLNAITGS 297 
CAG06234      633 edsaANetqsvitphlvltqvteadvflhpnpllygrrketrkrVYEQDDLSEQMASLEGLMKQLNAITSS 703  spotted green pufferfish
XP_022524542 1393 e-dpAS--------------------------------------VYEQDDLSEQMASLEGLMKQLNAITGS 1424 Mexican tetra
XP_012657451 1298 e-dsAN--------------------------------------VYEQDDLSEQMASLEGLMKQLNAITGS 1329 small-eared galago
XP_012821604 1374 e-gsEC--------------------------------------SYEPDELSKEMAHLEGLMKDLNAITTA 1405 tropical clawed frog
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