Conserved Protein Domain Family
RGM_N

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pfam06535: RGM_N 
Repulsive guidance molecule (RGM) N-terminus
This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but RGMA from chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.
Statistics
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PSSM-Id: 399502
View PSSM: pfam06535
Aligned: 28 rows
Threshold Bit Score: 150.561
Threshold Setting Gi: 1133455599
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003728654  66 CDIL-WCSYQYEADTDPLD-----PGPYPDF--CRALQRYQRCVDRISpGSCRGD--LHYHSTKTVIPDLQRNYECERVL 135 purple sea urchin
NP_955867     37 CRIQ-RCNAEYVASFSPSGglqeeVHPDVDY--CIALRAYSLCTRRTA-RACRGD--LVYHSAVFRIKELFAQHNCSSDG 110 zebrafish
XP_006008158  26 CRIQ-KCNAEYVAATSPNHglmedHLTDVDY--CIALRAYSLCTKKTA-RACRGD--LVYHSAVFRIKELFSQHNCSSVG 99  coelacanth
XP_002602038  82 CRVT-KCNSEFVASTSALNpa--hQRDLVLY--CRALRQATQCARRTA-RQCRGD--LHYHSTIRGFADLMQSHNCTHVS 153 Florida lancelet
EFX90410      12 CKVD-SCTRQFQQAAMASGv----RRGSAAF--CVILRQYSDCLRSTA-RSCRGH--LAYHSTITLVQNWNGDSNCSYVG 81  common water flea
XP_003111120  21 CRVE-ECAAWFQKTKDYENl---vPKATERY--CQVLQTYLKCMNDTQ-RFCHGN--LRFHSSELVMRRHWKEFECEKWE 91  Caenorhabditis ...
XP_002428231   8 CKAD-FCSSQYTESLDREKid--rPEPTEAS--CKILRNFGKCLRMTA-KECHGN--IPYHSSIVMVKQLSKENNCEALI 79  human body louse
3_pfamImport   1 -RLE-GCRREYTAGLEEAGiq--qPEPSPAY--CQELRLFGQCVQRTT-KGCRGD--LAYHSTSSLVDALAKRYNCSQHK 71 
XP_001623735  45 CQVQpKCTDPYVQ-----------READTAFklCASLKLYKLCLDRIR-KQCRGSggIYYNTVRTLVPVLMRNHKCDNVT 112 starlet sea ane...
EKC39746      64 CGMQ-LCYDRWRTAASAADng-liKPPNGEIpaCVAHRTHLFCLIAEE-QHCRTN--LQYQMTKRGIIHKMKNDKCSAVG 138 Pacific oyster
XP_003728654 136 reennpgptravett-trpsrnggdndsdsPGTNGRPPffpdilsDA-PETGGSQRCQYTGS----------RSFRHCGL 203 purple sea urchin
NP_955867    111 ------------------------------PTSSAKAP--------StSKPTVVDICNYESRvlasgpaaqqKKYGHCGL 152 zebrafish
XP_006008158 100 ------------------------------PTSSFKAA--------GtTKPLVSEICNYESRtg------fqKKFAHCGL 135 coelacanth
XP_002602038 154 de--------------------------pvPTRPTQE---------Q-----LPQMCAYRGgs--------nTVYRHCGL 185 Florida lancelet
EFX90410      82 gasgaggapaifnkdrprnhdhhspkvddsP------------------------SCTYQGR----------PEVTHCSF 127 common water flea
XP_003111120  92 scnekn-------------------edkrrP----------------------VNTCYFNPPps-------sRKIKYCSL 123 Caenorhabditis ...
XP_002428231  80 gpekt---------------------lpspPLLRPSIIpklpvntVP-VSVVTQRSCTFLGK----------NKFRYCGL 127 human body louse
3_pfamImport  72 lrgerr-------------------qgvarP---------------------AHLACTYHRaq--------tVVKQECGL 103
XP_001623735 113 lpekekgllnif------kkrqmqgnippkPTVKPK--------------------CTRTKRlys-----ksEEKKYCGL 161 starlet sea ane...
EKC39746     139 dafnasav--------------mdkgiiirP---------------------NNLICTFRSKydk-----tpIKYQHCGL 178 Pacific oyster
XP_003728654 204 FGDPHLRTFDDLFQTCKVAGAWPLIYNDYLTAQVTNVPLV----HGSGATATNK------LTVIIK 259 purple sea urchin
NP_955867    153 FGDPHLRTFRDEFQTCRVEGAWPLIHNRYLSVQVTNVPVV----EGSSATATNK------ITVIFK 208 zebrafish
XP_006008158 136 FGDPHLRTFKDEFQTCKVEGAWPLIDNRYLSVQVTNVAVV----LGSSATATSK------ITVIFK 191 coelacanth
XP_002602038 186 FGDPHLRTFYDDFQTCKVDRAWPLIDNAYLAVQVTNVPVAvaasHGFTATATTK------LTVIVK 245 Florida lancelet
EFX90410     128 YGDPHLVTFNGDFQTCKVAGAWPLIDNAYLAVSVTNEAVV----PGSSATATTK------ITIIIK 183 common water flea
XP_003111120 124 FGDPHLIMFNGTIQTCSEEGARPLVDNRYFLVQVTNKNVR----GEALTTTVTK------VTVLIR 179 Caenorhabditis remanei
XP_002428231 128 FGDPHLKTFHSKYQTCKLKGAWPLIDNPYLAVSVTNEPVI----ENSPATVTTK------VTVIIK 183 human body louse
3_pfamImport 104 YGAPDLRTFSSHYQKCNVVGTWPLLDNDYLAVQITNSRI-----DQSLGIATTKalfykqITVIIK 164
XP_001623735 162 FGDPHLRTFGDAKQTCVVEGAWPLVENHFLIVQVTNVPLV----DGSSATATNK------ITVIIQ 217 starlet sea anemone
EKC39746     179 FGDPHLRTFKDEFQTCKVEGAWSLVQNKYIMIMVTNNPVK----DHGAATATSK------LTVVIK 234 Pacific oyster
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