Conserved Protein Domain Family
FGF-BP1

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pfam06473: FGF-BP1 
FGF binding protein 1 (FGF-BP1)
This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development. Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind fibroblast growth factors (FGFs) 1 and 2.
Statistics
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PSSM-Id: 399467
View PSSM: pfam06473
Aligned: 41 rows
Threshold Bit Score: 175.247
Threshold Setting Gi: 172046097
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007230364   6 STVLLLACCVWV---IHAQAQSSQSVANQDnsnqanvhanestpslpskAKQEPQQPNSVWDEPIRFSSKAKDSCTLVI- 81  Mexican tetra
XP_003783746  12 LLLLLGGCFLAA---GRRDQGAAGSAVEPV-------------------------PPGPRGGSSGRFISPEQHACSWQLl 63  small-eared galago
XP_012910191   8 LLLLLGGCLLVA---ARRAKGTAGSAAELA--------------------------SGPTGGSSGRFVSPERHACSWQLl 58  domestic ferret
XP_006926013  11 SLLLLSGCLLAT---AQRDKGVGGSAAESA--------------------------WGHTGGSSGRFVSPERHTCSWQLl 61  black flying fox
XP_005991629   7 LLTVLLFHCLCS---LQEVGAKKEK-------------------------QAGKRGKIK-FPTSGEFITKDSHACTWEI- 56  coelacanth
XP_015201750   4 lCVLAFVLCLYG---LPGTEGKRDSRNSTQ---------------------LAKKGRSKSVPSSGELITKDSHRCTWEA- 58  spotted gar
XP_005806167   8 CVFLLCLVFLAE---AKRTPGQDKRDKPRQpq---------------ssPPPARRSRNRSVLSSGELSTKQGHRCTWQT- 68  southern platyfish
XP_003455729   9 LILLLLIPILTE---AKRQPGQEKPDKPRQpp---------------psPQPAKRPRNRSVPGSGELTSKEGHRCVWQT- 69  Nile tilapia
NP_001072192  21 ISFLSFVICLIP---APGVLGKNEK-------------------------APSKRGEKQAFAPSGQFSTKHQHECTWEI- 71  tropical clawed...
XP_012395950   8 FPLLLLGCCLLAvstARKNKDSSRAATESV--------------------------PGPAGGSSGRFSNPEQHACSWQIl 61  Tasmanian devil
XP_007230364  82 ---------SGQ---GDFTKLRVSCKNK----GKSYWCDFLGKPNLCRPYnKNPRHYFTQVMWELRKLPNACQGPRVYKP 145 Mexican tetra
XP_003783746  64 lpt---------pgaaEGSELALRCQGPd---GARHQCAYRGEPERCATYtARRSHYWKQVLGALRKKRRPCHDPSPLQA 131 small-eared galago
XP_012910191  59 prv---------pgpaAGSELALSCRDPa---GALQQCAYRGEPERCAAYvARGPHYWKQVLGGLRKKRRPCQDPAPLKA 126 domestic ferret
XP_006926013  62 lpa---------pgqvVGSELALLCQGPd---GARQHCAYRGEPERCAAYaTRGSLYWKQVLGRLRKKPRPCQDPAPLKA 129 black flying fox
XP_005991629  57 ---------SGD----EEISLLVICPQQ----DNNYWCKYTGQPHQCLSYnTRTSQYWKQILGKLKKKKNACE-DKTLKS 118 coelacanth
XP_015201750  59 ---------SGE----GEVTLLINCNHQ----DQTYWCQYLGKPTLCPVYnSKSSQYWKQVVSKLKKKKNPCEGDKILKT 121 spotted gar
XP_005806167  69 ---------SGE----GLVSLVVNCSTEsegdAERYWCRYAGKPNLCQAYsMKSSQYWKQLVGKLKKRENACEGEKVLKA 135 southern platyfish
XP_003455729  70 ---------SGE----GLVSLLVNCSIEtqgdLQRYWCRYAGKPDLCQAYgVKSSQYWKQLVGKLKKRQNACEGEKVLKA 136 Nile tilapia
NP_001072192  72 ---------TGD----QIVNFTVLCNQQg---VNSYNCTYTGEPLKCPSYkTKAKQYWKQILGKFKKVKNACE-EKILRS 134 tropical clawed...
XP_012395950  62 lpapgdstaTGAegvGAGSELAVSCQSPd---GSRYQCAYRGEPQRCAAYnARGPQYWKQVVGKLRKKRRPCHDPAPLKA 138 Tasmanian devil
XP_007230364 146 QMC--RTAGD-----------------------EAQMVFHNswpktt--------------------------------- 167 Mexican tetra
XP_003783746 132 RLCagKKGH------------------------GAELRLVSgasqpahpt------------------------------ 157 small-eared galago
XP_012910191 127 RLCagKKGH------------------------GAELRLVPhgsspvrpt------------------------------ 152 domestic ferret
XP_006926013 130 RLCagKKGH------------------------RAELRLVPhafppagpt------------------------------ 155 black flying fox
XP_005991629 119 RIC--KRGPT-----------------------EAHLRLVEksfs----------------------------------- 138 coelacanth
XP_015201750 122 RLC--KKSPV-----------------------ESHMKLSEkssa----------------------------------- 141 spotted gar
XP_005806167 136 KTC--KKAPG-----------------------EAHMKLAQrs------------------------------------- 153 southern platyfish
XP_003455729 137 KTC--KKAPA-----------------------EAHMKLAQrs------------------------------------- 154 Nile tilapia
NP_001072192 135 RIC--KKSAAvesqltkvdvgadeqgkniktkgKTHIKESAkgae----------------------------------- 177 tropical clawed...
XP_012395950 139 RLCggKKGL------------------------GAELHLVTrpldaanagvssaatalpregkgrskgrprgqsrareaa 194 Tasmanian devil
XP_007230364 168 ---------tsapvtAPQDRSQSQPKQPQPPKTSATPK-PPt-------AAKAVPKTPKQpt-kPVLPRKPSKTTta-kp 228 Mexican tetra
XP_003783746 158 -------pagfpgepKPRARSRGRSREHAAGLApsv----------rpkEKKTKGDKRKAa--sDPHEERPMGTGp---- 214 small-eared galago
XP_012910191 153 -------aavfprdpEPPARSRGRLREPAPGPAGGSRLpESksprgkpsE-KTKAGKRKAt--sDPEEERPLGTRp---- 218 domestic ferret
XP_006926013 156 -------aagylrdlKPRARSWGRPQEPAIRPAARVPPlPSsppkgkpsKKKTKGGKRKAa--sAAVEERPLGTRp---- 222 black flying fox
XP_005991629 139 ------------sgkEERGKSKASGRKKDSEKTAVESKdELvnt--gvsEKRGKTGKRKSkpypTSAKQAEATTSpagev 204 coelacanth
XP_015201750 142 -----------daraEDSAKGKGGGRKKEAAP---------------------EVADRKKekkpPVAEK-----Edfgev 184 spotted gar
XP_005806167 154 -------------geEDKNAAKEGGKKKGEAGAKs--------------SDGGKVEKRKKkvkeDEAEKKKR--Eertef 204 southern platyfish
XP_003455729 155 -------------geDDKKGGKEGGKKKPAGKs----------------VGGGRMDKRKKkeeeTEEKKKRR--Eertea 203 Nile tilapia
NP_001072192 178 -----------qrpkSPEVSEDDGGDQKSSs------------------KKRKPASKSNHkpspPTPSTLPSLATaarev 228 tropical clawed...
XP_012395950 195 agaeeglnlprapppSGASAVSGVAKEKGPG-------------------KRGNAGKRKEt--pPSDEERPMEAGp---- 249 Tasmanian devil
XP_007230364 229 TTEp-ENRATKLAEEYCWSGIQNVCAYFIGWF 259 Mexican tetra
XP_003783746 215 YADa-LDENTELTKTYCAEKWHSLCNFFVNFW 245 small-eared galago
XP_012910191 219 DPDg-LDENAKLTETYCAEKWHSLCNFFVNFW 249 domestic ferret
XP_006926013 223 DPDg-LDENAKLTETYCAEKWHSLCNFFVNFW 253 black flying fox
XP_005991629 205 NDDd-SEFNEDLAEAYCAEKWHSLCSFFVNLW 235 coelacanth
XP_015201750 185 NDEn-AESEMEPVENYCADGWHSLCNFFVKLF 215 spotted gar
XP_005806167 205 DDEg-MVNDMEPVQTYCSDGWHSVCSFFVKFF 235 southern platyfish
XP_003455729 204 EDEegMQSDMEPVQAYCSEGWHSVCSFFVKFF 235 Nile tilapia
NP_001072192 229 NDDi-IELNEDLAETYCAEKWHSLCSFFVNFW 259 tropical clawed frog
XP_012395950 250 APGgpLEFNEELTETYCAEKWHSLCNFFVNFW 281 Tasmanian devil
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