1I4D


Conserved Protein Domain Family
Arfaptin

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pfam06456: Arfaptin 
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Arfaptin-like domain
Arfaptin interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix coiled-coils. The N-terminal region of ICA69 is similar to arfaptin.
Statistics
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PSSM-Id: 399453
View PSSM: pfam06456
Aligned: 11 rows
Threshold Bit Score: 232.632
Threshold Setting Gi: 14277762
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1I4D_B   1 GSR----TVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQ--KSPElQEEFGYNAETQKL 74  human
P97411  43 KEDehvvASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFqdKTRA-GKMMQATGKALCF 121 house mouse
Q62083 137 LGLsraiLCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVrePQPAaSEAFVKFADAHRS 216 house mouse
Q8SY07 139 LGLsraiLCNDSLVKRLEELEGTELMYKGLVEHARRMLKAYYDLLQTYKSFGDCFTQISVhePQQRaSEAFRTFGEFHRT 218 fruit fly
P34445  88 IDK----TVDPEFEAQCEVLKDIHRRYGLVVAAAKNFSHVLTQMAEAEKKLSESFYQLSM--KEEQiKAQCTMTSETMRG 161 Caenorhabditis elegans
Q9VGQ8 135 SQR----TVDSELEAQIEQLRETQRKYLSILRLTRAFSSHFQHVVVTQHALADSFADLAQ--KNPElQKEFTCNSETQRN 208 fruit fly
O18246 133 LGLsraiLTNDPLAEKEKILEENAEFYRHLVAYFGDMFQYQQKISECQKEFGSIFCDLAAheKQQTaNEAFSSFGDKHRM 212 Caenorhabditis elegans
P53367 150 GSR----TVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSL--KSLElHEEFGYNADTQKL 223 human
Q3TY65  37 KEDehvvASDAELDAKLEVFHSIQETCNELVKIVEKYQLRLNVISEEENELGLFLKFQAErdSTQA-GEMMDAAGKALCS 115 house mouse
P91124  49 KEDehleASDNELDTCLNLYRSVHGTSFQLLNNVDNYANFLLDETLVQNVLGKYLKEKGKidKTEAvGRILIAVGRSLLF 128 Caenorhabditis elegans
Q9VP78  24 KEDkhiiSSDAELDSKIEVFKSISDTSLNLCKIIDQYQERLCILSQEECVFGRFLKEAGK--RSRTtGGSIAHTAKAVSF 101 fruit fly
1I4D_B  75 LCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELS--LGPRDAGTRGRLESAQATF---- 148 human
P97411 122 SSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSqeLDPDLYKQMEKFRKVQTQV---- 197 house mouse
Q62083 217 IEKFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDdeEYSCIGPRRALYRVSTGNYeyrl 296 house mouse
Q8SY07 219 LEKDGLGIIKQIKPVLADLGTYLNKAIPDTKLTVRRYADAKFTYLSYCLKVKEMDdeEHGFAALQEPLYRVETGNYeyrl 298 fruit fly
P34445 162 VGEQAASLDACLRYFISSMETVYNQTITDTLHTIYNTESARIEYDVDRNDISAAT--NPPQGQLTKNLPVGATEKC---- 235 Caenorhabditis elegans
Q9VGQ8 209 LTKNGELLLNALNFFISSVNTLCNKTIDDTLLTIRQYETARIEFDAYRMDLENTKpeLTPSAVA----LEETQRSY---- 280 fruit fly
O18246 213 IAKKQSESAVPLQKMVSDLQVYIDHVVPDTRLTIKKYLDVKYEYLSYCLKLKEMDdeEVEFVAIQEPLYRVETGNYeyrv 292 Caenorhabditis elegans
P53367 224 LAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELN--LGPRDANTLPKIEQSQHLF---- 297 human
Q3TY65 116 SAKQRLALCTPLSRLKQEVATFSQRAISDTLVTINRMERARTEYRGALLWMKDASqeLDPDTFKQMEKFRKVQNQV---- 191 house mouse
P91124 129 SSHRLNAARIGVSTFYNKLSVFVERAIGDCSQTIEAVQMCRTEYRGSLLWMKKTSeeLDPEVDGSMEKFREAQTTV---- 204 Caenorhabditis elegans
Q9VP78 102 AGQQRMCVRVPLLRLQHEVDVFRCRAIKDTEQTLQTMEKERTEYRAALSWMKSASqeLDPDTGKGLDKFRTAQAHV---- 177 fruit fly
1I4D_B 149 -----QAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQL 199 human
P97411 198 -----RLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTM 248 house mouse
Q62083 297 ilrcrQEARARFSQMRKDVLEKMELLDQKHVQDIVFQLQRFVSTMSKYYNDCYAVL 352 house mouse
Q8SY07 299 ilrcrQDARSKFAKLRTDVLEKMELLECKHAMDLNKQLRSLLESLAELHRSLVDRL 354 fruit fly
P34445 236 -----EEKKAKYEKLKNDAKIKMRLLEENRISVVAAQLEKLQSALAAYYSGNAKLL 286 Caenorhabditis elegans
Q9VGQ8 281 -----AQHKEQYEKLRSDVAVKMQFLDENRIKVMHKQLILLHNAIAAYFSGNAMAL 331 fruit fly
O18246 293 mlrcrQECRARFMKMRDDVMVKIELLDQKHVRDIAQHLAIFAKTMAKCQQECAEIL 348 Caenorhabditis elegans
P53367 298 -----QAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQL 348 human
Q3TY65 192 -----RNSKDSFDKLKKDVCQKVDLLGASRCNMLSHSLTTYQRTLLGFWEKTAQMM 242 house mouse
P91124 205 -----KSNKERLDRLKTDTLQKVDLLSASRSNLLSYVLTHYQNELYEYYSKTSRAF 255 Caenorhabditis elegans
Q9VP78 178 -----RVAKHNFDGYSMDSIQKIDLLAAARCNMYSHALVAYVTELKNFAQKAASTF 228 fruit fly
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