Conserved Protein Domain Family
ISN1

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pfam06437: ISN1 
IMP-specific 5'-nucleotidase
The Saccharomyces cerevisiae ISN1 (YOR155c) gene encodes an IMP-specific 5'-nucleotidase, which catalyzes degradation of IMP to inosine as part of the purine salvage pathway.
Statistics
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PSSM-Id: 399443
View PSSM: pfam06437
Aligned: 53 rows
Threshold Bit Score: 653.053
Threshold Setting Gi: 74695713
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK43258              1 MTSRYRVEYALKSHRRDEFIEWIKTLLACPFVLHADVESYNlaypnlyevpdddkdsrfkQHEIDVAQDCQRRYLEIFKD 80  Lodderom...
WGS:AATM:SJAG_03096   1 MATRYRVEYALKVHRKDNFIEWIKGLLAVPFTLQTGHFADK-------------------YEATKHANETLKRYATVLRD 61  Schizosa...
Q6FLD4                1 MSSRYRVEYHLKSHRKDGFIDWIKGLLAAPFVLHAVSHdg------------------ddNDELATTQRVRSQYAEIFKD 62  [Candida...
XP_003687548          1 MSSRYRVEYQLKAHRKDEFIDWIKGLLAAPFVLHAVSH----------------------DNEDGTTERVRKQYAEIFQD 58  Tetrapis...
XP_004180203          1 MSSRYRVEYQLKQHKKDEFIEWIKALLATPFVLHAVSH----------------------IEEEATTQRVRTQYADIFQD 58  Tetrapis...
XP_002555171          1 MPSRYRVEYQLKSHRKDELIEWIKGLLAVPFVLHSASH------------------------DPAARQILRQRYAEVFVA 56  Lachance...
Q6CY84                1 MSSRYRVEYNLKVHKKDAFIEWIKGLLAVPFVLQAGTD--------------------------SGAERTYKQYCSIFSD 54  Kluyvero...
Q75EG6                1 MSSRYRVEYQLKAHRKDAFIEWIKGLLAVPFVLHSVTE----------------------------RDNAQEKYRRVFED 52  Eremothe...
ybcl:Ecym_5451        1 MSSRYRVEYHLKTHRKDQFIDWIKGLLAVPFVLHSVTA----------------------------ASTAREKYKNVFID 52  Eremothe...
XP_013934138          1 MTSRYRVEYALKEHRRDGLIEWIKGLLATPFVLYAVKSNGIs-----------------aVDDLMVNSEAKRRYAEIFHD 63  Ogataea ...
EDK43258             81 VEQLIDHTILMDqlndqqqktlypNP----------------RYTLSRLRNLVPSIGRFFTKLPLSEAFLVEDERRGISK 144 Lodderom...
WGS:AATM:SJAG_03096  62 VEYLINSHIEHIrq--------------------------fgERGSSRLKMLVPSITNFWTPLPLERAMYILEPRLCLAK 115 Schizosa...
Q6FLD4               63 IESLVSDKILFDe-----------RNdqyrqyiesndveeviPLGQPRLDLLVPTIGTFFTQLPLEKAFLWEDARKAISS 131 [Candida...
XP_003687548         59 IENLINKKIESD------------KQnglldnedvgfskqyeIVEKSRLKQLVPSIGPFFTALPLEEAFLWEDSQKAISQ 126 Tetrapis...
XP_004180203         59 IESLIQHKIEFDn-----------KRglldekgdssqnqkyeFIGKSRLNRLVPSIGPFFTPLPLTRAFLWEDDKRAISE 127 Tetrapis...
XP_002555171         57 VEALIDEQVSVGklarqs-------------------edrefLVGRTRLAQLVPSIGPFFTRLPLRQAFLHEDHKRAISA 117 Lachance...
Q6CY84               55 IENLVSQKIEIQnrrr-----------------------qlgSLEEARLDQLVPQVGTFFTHLPLVEAFEVQNRRRAICS 111 Kluyvero...
Q75EG6               53 VETLINEKITVDsdes-----------------------ltrAAGVSRLDKLVPTIGTFFTPLPLTEAFLRQNARRAISE 109 Eremothe...
ybcl:Ecym_5451       53 IENLIEEKRKIDsdes-----------------------lthGLHISRLDRLVPSIGRFFTPLPLAEAFLQQDEKRAISA 109 Eremothe...
XP_013934138         64 LELLIDDNIEMT------------KAg---------------TPELSRLVQLVPSVGNFFTRLPLEKAFYIEDERRAISK 116 Ogataea ...
EDK43258            145 RRLVAPSFNDVRMILNMAQIMALTEInrel--grtHLKLITFDGDVTLYEDGQSLVEGSDVVKRLVQLLAMGVYVGVVTA 222 Lodderom...
WGS:AATM:SJAG_03096 116 RRFVAPSFNDVRYLLGAAQLLYLAEN---------GLDMVTFDGDVTLYEDGQPLISNNPVISRLLHLLREDKFVTILTA 186 Schizosa...
Q6FLD4              132 RRMVAPSFNDIRHILNTAQVFHFIKQrklk--skdQLRMCTFDGDVTLYEDGGSIVNTNPVIPLLVKLLSEGVCIGIVTA 209 [Candida...
XP_003687548        127 RRMVAPSFNDIRHILNTAQVFQFIKQkrl---nsnTLKLVTFDGDVTLYEDGGSLVDSDPVVPYMVRLLESDIRVGICTA 203 Tetrapis...
XP_004180203        128 RRMVSPSFNDVRHILNTAQIFHFISAkenh--saeQLKLVTFDGDVTLYEDGGSITDNNPVVPLIMKLLKNDIRVGIVTA 205 Tetrapis...
XP_002555171        118 RTMVSPSFNDIRHILNSAQILQMRECh--------DVRLVTFDGDVTLYEDGGSLTATSKVVPFLLSLLRSGICVGIVTA 189 Lachance...
Q6CY84              112 RKMVSPSFNDIRHILNSAQILALLKSk--------ELKLVTFDGDVTLYEDGGSIERGGKIVTRIITLLKRGINVGVVTA 183 Kluyvero...
Q75EG6              110 RAYVSPSFNDIRHILNTAQIVQLARAg--------ELSLVTFDGDVTLYEDGASLAAEDKVIGRLLRLLGAGMHVGIVTA 181 Eremothe...
ybcl:Ecym_5451      110 RTLVSPSFNDIRQILNTAQILQVARSg--------ELRMLTFDGDVTIYEDGGSLAPKAKIVTRLIRLLEMGLYIGIVTA 181 Eremothe...
XP_013934138        117 RRLVAPSFNDVRLILNTAQLLEMSRFfhsktirdrKLQLITFDGDITLYDDGKNFDAESPILPHLIKLMAKDLYVGIVTA 196 Ogataea ...
EDK43258            223 AGYpgqSGAVKYEERLKGLIDYLNREDgscILTKEQKENLLVMGAESNYLFRYNA-QLKG---LKFIDSEEWHLPQVQKW 298 Lodderom...
WGS:AATM:SJAG_03096 187 AGYp-sVTGREYSDRFSGLLSAVEDS----DLTDVQKKRLHVLGGESNYLFRYEP-SSg----LTWIEPEEWSLPQMLTW 256 Schizosa...
Q6FLD4              210 AGY---DEAKTYESRLNGLITALNGS----DLPYAKKRNLCVMGGESNYLFRYYE--DGEsfgFEAIDKEGWLLPRMCTW 280 [Candida...
XP_003687548        204 AGY---DEALKYQERLHGLLVAIYSST---SLTQDQKCNLTVMGGESNYLFQYFEnPETGefgFRPIDKDLWLLPEMRTW 277 Tetrapis...
XP_004180203        206 AGY---DEPAKYVERLNGLIKAMYNST---ILTTRQKENLTVMGGESNYLFQYHE-DESNrfgFQTIECGKWMLKDMQDW 278 Tetrapis...
XP_002555171        190 AGY---DEAQKYMERLFGLMTSLKDDT---SISADFKRNLVVLGGESNYLFRY----EPSqheLVSIENKAWIKPPMCHW 259 Lachance...
Q6CY84              184 AGY---DDPDKYKERLYGLCFALFSDK---SMSLEQKSKLTVMGGESNYLFQYFE--TSEqfgFKSIDDDEWVPSSVKAW 255 Kluyvero...
Q75EG6              182 AGY---DDAENYERRLFGLLRRLERA----DLPNEAKRRLCVMGGESNFLFRCYE--RDGragFERVPESVWMSAELHQW 252 Eremothe...
ybcl:Ecym_5451      182 AGY---DDSENYEQRLVGLIKELEQSP---HLSLEVKKRLCVMGGESNFLFQYDE--ENSrakFKKVSEYDWMPQELHGW 253 Eremothe...
XP_013934138        197 AGY---SDATKYYERLKGLIDAVQTSP---LLRGHQRENLLIMGGEANYLFRYSN-EEQK---LRFYSKDRWLLENMLNW 266 Ogataea ...
EDK43258            299 DNDKIKYIMHTCHHHLIHLQQKFQLEdtTTIIKKERSVGIIPNP----------GQKILREQLEEMVLSCSKKLEvilks 368 Lodderom...
WGS:AATM:SJAG_03096 257 SREDCQRILDVAELCFKKCIEALNMD--AVLVRKERSVGLVPKP----------GHTFRREQLEEAVLDTQSNLL----- 319 Schizosa...
Q6FLD4              281 SQDDLTQTLDFAEKTLYRLKKRLNLPeeAIIMRKARAVGIVPGHfkdpetgnmvKIQLDREQLEEVVLTLQNSLE----- 355 [Candida...
XP_003687548        278 EESDMDLTLDFAEQTLIHMKKTLKLPpeTVLIRKRRAVGLVPGEkfdhikgktvRVKLSREQLEEIVLTLQNTLD----- 352 Tetrapis...
XP_004180203        279 DPLSIEHTLDFAEKTLQTLRTRLRLPkeTMIIRKARAVGLVPGEiqdpitsqkrRLLLSREQLEEVVLTLHQTLM----- 353 Tetrapis...
XP_002555171        260 SESDMTETLDLAESLLRDFRTTLNLPeeSTIIRKPRAVGIVPGNrwnpetkrtiRVKMDREQLEEMVLTLQHRLE----- 334 Lachance...
Q6CY84              256 SDDDIDATLDVAQTCFGELSHLLALPskCQIIRKKRAVGFVPGFifddelevnvKIKIPREALEEMVLVVQKKLE----- 330 Kluyvero...
Q75EG6              253 NQQDINATLDLAEVMLRALREKLRLPaeTQIIRKVRAVGIVPGQrfdpelgreiRVPLLRETLEEIVLTVQGRLE----- 327 Eremothe...
ybcl:Ecym_5451      254 GHEDIKATLDLAETTFKKLKQSLKLPpeTTIIRKNRAVGIVPGQrwdpelqefvRVTILRESLEELVLSVKTHLD----- 328 Eremothe...
XP_013934138        267 SEEDILLTLDFAQEVLNDLVHKLGAP--ATVVRKERAVGLVPLQ----------GYKLIREQLEEIVLRVDKRLK----- 329 Ogataea ...
EDK43258            369 tdntttqttqtsrsqasndstdefttsagattattssfdpaSSSPLSDIKVCAFNGGSDVWVDIGDKALGVESLQKYLCQ 448 Lodderom...
WGS:AATM:SJAG_03096 320 -----------------------------------------MENFS--IPFTAFNGGNDIWCDIGDKKLGVQCLQAYFGV 356 Schizosa...
Q6FLD4              356 -----------------------------------------GFAPAQRIQYSCFDGGSDVWCDIGGKDLGVRALQHYYDP 394 [Candida...
XP_003687548        353 -----------------------------------------TFKPATRVQFSCFDGGSDVWCDIGGKDLGVRILQNFYSP 391 Tetrapis...
XP_004180203        354 -----------------------------------------SYPMARKIQFSCFDGGSDVWCDIGGKDLGVTILQKFYDP 392 Tetrapis...
XP_002555171        335 -----------------------------------------DFAPARRIQFSCFDGGSDVWCDIGGKDLGVAALQHYFDP 373 Lachance...
Q6CY84              331 -----------------------------------------SYPPAQNIQFSCFDGGSDVWCDIGGKDLGVSILQNFYQT 369 Kluyvero...
Q75EG6              328 -----------------------------------------NFPPAQRVQFSCFDGGSDVWCDIGGKDLGVAFLQRFYSP 366 Eremothe...
ybcl:Ecym_5451      329 -----------------------------------------AFPPAQRIKYSCFDGGSDVWCDIGGKDLGIQSLQYFNDP 367 Eremothe...
XP_013934138        330 -----------------------------------------QFPPAKKIRWCAFNGGSDIWVDIGDKAYGVRVLQKFISS 368 Ogataea ...
EDK43258            449 DESndlcpIRKAESLHIGDQFALL-GANDFKARLSACTVWIANPAETVAIL 498 Lodderomyces elongisporus NRRL YB-4239
WGS:AATM:SJAG_03096 357 --------PESSRCLHVGDQFLSV-GHNDYKARAAATTVWVSSPTETIEML 398 Schizosaccharomyces japonicus yFS275
Q6FLD4              395 ENP-----IKPSQTLHVGDQFAPVgSANDFKARLAGCTLWISSPKETVEYL 440 [Candida] glabrata CBS 138
XP_003687548        392 NNP-----IKPYETLHVGDQFNPSgLANDVKARLAGCTLWIASPHETVQLL 437 Tetrapisispora phaffii CBS 4417
XP_004180203        393 QNI-----IKPSETLHVGDQFSPMiQANDIKTRLAGTTLWIASPAETVDAL 438 Tetrapisispora blattae CBS 6284
XP_002555171        374 YNP-----IKPCQTMHIGDQFAPMgSANDFKARLSGCTLWISSPQETVEVL 419 Lachancea thermotolerans CBS 6340
Q6CY84              370 DSP-----ITAAQTLHIGDQFAPKgSANDFKARSAGCTLWISSPRETIEVL 415 Kluyveromyces lactis NRRL Y-1140
Q75EG6              367 ERP-----IRPEQSLHVGDQFAPVgSANDFKARLAGCTAWISSPQETVALL 412 Eremothecium gossypii ATCC 10895
ybcl:Ecym_5451      368 LNP-----IKPNESLHIGDQFAPVgSANDFKARLSGCTVWISSPQETLETL 413 Eremothecium cymbalariae DBVPG#7215
XP_013934138        369 NDKi---dIKAENTLHVGDQFNSL-GSNDYASRTAATTCWVSSPDETKNLL 415 Ogataea parapolymorpha DL-1
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