Conserved Protein Domain Family
Mgm101p

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pfam06420: Mgm101p 
Mitochondrial genome maintenance MGM101
The mgm101 gene was identified as essential for maintenance of the mitochondrial genome in Saccharomyces cerevisiae. Based on its DNA-binding activity, and experimental work with a temperature-sensitive mgm101 mutant, it has been proposed that the mgm101 gene product performs an essential function in the repair of oxidatively damaged mitochondrial DNA.
Statistics
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PSSM-Id: 428931
Aligned: 45 rows
Threshold Bit Score: 211.685
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011108443  92 DWSRSFSGLSQTPFAKEVSDVLLQPLDPAEVEIKPDGIIYLPEIKYRRILNRAFGPGGWGLAPRGETQISEKpngggI-- 169
XP_001732005  99 EWHSGYQGIGLRPFPAQVAHVLCEPVDKNDVEIKPDGLLYLPEIKYRRILNRAFGPGGWGLAPQGEPEVSQG-----I-- 171
XP_012192011 155 EWGTSFAGLGERSFSREAIDVLMAPVNEGDVEIKPDGLIYLPEIKYRRILNKAFGPGGWGMAPRSETNVGQG-----I-- 227
Q00970        93 NWYTSYHGIGSKPFSDETQNALSSALNADDIEIKPDGLIYLPEIKYRRILNKAFGPGGWGLVPRSETIVTAK-----L-- 165 Kluyveromyces l...
EDV25505      55 teKDDFVGIAASPFPKESADILMAPVKAEDVEVKPDGLLYLPEIRYRRILNQAFGPGGWALMPRGQPTMINN-----Ege 129
EFC42728      72 nGTTVYERIGKQPFSEEIAQILMAPLPDQDIEVKPDGILYLPEIKYRRILNKAFGPGGWCLVPLSEFKIERG-----S-- 144
Q8MYF0        72 yQEDKYQGISKEPFSKEIVDTLLADLNPDDIEIKPDGLIYLPEIKYRRILNQAFGPGGWALKPFGPPVVEGK-----T-- 144 Dictyostelium d...
EGC36966      58 ySEEKYQGISKEGFPKDVTDVLLAELNPVDIEIKPDGLIYLPEIKYRRILNQAFGPGGWALKPFGPPVVEHK-----T-- 130
EFA83373     114 yQEEKYHGISKEPFAREISDILLAELNNHDIEIKPDGMLYLPEIKYRRILNQAFGPGGWALKPMGPPIVENQ-----S-- 186
XP_004362560  82 ySEEKFIGIAKEPFAKEINNILMGELDSQDIEIKPDGIIYLPEIKYRRILNQAFGPGGWALKPFGPPVVIDG-----S-- 154
XP_011108443 170 ----VTREYALVCHGRLVSVARGEQDYFDEFG--IPTAMEACKSNAMMRCCKDLGVASELWDPRFIRKWKKENASELFGE 243
XP_001732005 172 ----LSREWTLICLGRFVSTARGEQEFFKPTG--IPTANEGAKSNALMRCCKDLGIASELWDPRFIRQFKAKHCVEVWCQ 245
XP_012192011 228 ----VSREWVLICQGRFVATARGEQEFFKPSG--VPTASEGAKSNALMRCCKDLGISSELWDPRFIRQFRKKHCVEVWAQ 301
Q00970       166 ----VTREYALVCHGQMVSIARGEQDYFSETG--IPTATEGCKSNALMRCCKDLGIGSELWDPVFIKQYKKKHCTEKFVE 239 Kluyveromyces l...
EDV25505     130 lsqlVIREFALYVGGRFVAQSVGEHLHYSKNElsTGKALESAKSNALMRCCKDLGVASELWDPTFVYNFKKNHCVEVWCE 209
EFC42728     145 ----ILQEYGLFCRGQFVSQSFGEQTVDEQGYksIGSSLEGAKSNALMRCCKDIGIGSELWDPNFIIAWRAKNVVEAFCE 220
Q8MYF0       145 ----LIRPYALYCLGRYVAESIGEQQYVPNSFisFATATESAKSNALVRCCKDLGIGSSLWDPIFIRQWKSEYATERWCE 220 Dictyostelium d...
EGC36966     131 ----LMRPYALYCQGRYVSESIGEQAYFEGSFisFATATEAAKSNALVRCCKDLGVGSSLWDPTFIRQWKSLYATEKTFE 206
EFA83373     187 ----LIRPYALYCLGRYISESIGEQPYSDSGFisFATATEAAKSNALVRCCKDLGIGSSLWDPNFIRAWKQQFAIERFYE 262
XP_004362560 155 ----LIRPYALYCMGRYVSESLGEQPYVEGGHlsFATANEAAKSNALVRCCKDLGIGSSLWDPTFIREWKQNNAEEKFYV 230
XP_011108443 244 HV-VTKKKKKLWVRKGD--SL-DYPY 265
XP_001732005 246 T--SDGKKKRYWRRKDDe-PF-QYPA 267
XP_012192011 302 D--TTGKKKKLWRRKDDp-AF-EYPW 323
Q00970       240 HV-TTKKKKKIWLRKDR--EV-EYPY 261 Kluyveromyces lactis NRRL Y-1140
EDV25505     210 NArNSKEKRKLWRLKRQgnDVlPYPW 235
EFC42728     221 HV-TKKTTKKLFRRHDR--EF-TYPY 242
Q8MYF0       221 NS-KTKERRLFWFLSNRseNQlPYPW 245 Dictyostelium discoideum
EGC36966     207 NV-KSKDRKVFWVLNNGipNQlPYPW 231
EFA83373     263 NV-KTKEKKKLWTTKSN--PApGYPW 285
XP_004362560 231 HV-KTNDKKKLWTLKDGsnPM-GYPW 254
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