Conserved Protein Domain Family
HdeA
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pfam06411: HdeA 
HdeA/HdeB family
HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localized in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS. This family also contains HdeB.
Links
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Statistics
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PSSM-Id: 399423
Aligned: 23 rows
Threshold Bit Score: 72.015
Threshold Setting Gi: 120587260
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
jgi:Aave_0086       12 LSSLAAAAAMaqtpspaAPSAAATNPAAatapAAKARKPLVKTTCSDYV----GMDETVKPKFIYYAVGHTQ-GGKKEAV 86  Acidovora...
WP_004236529         6 VTACLVAASA--------FSSVALAEPAd---IQVPD----KMTCKEFV----NLNPQSWAPVALWVISKDTqYPGGDFV 66  Morganella
P0AET2              13 MGAVAALSLV--------NAQSALAANEsa----------kDMTCQEFI----DLNPKAMTPVAWWMLHEETvYKGGDTV 70  Escherich...
Q7CQI8               8 tagIIVAALV--------TSVSVNAATDttktNVTPK----GMSCQEFV----DLNPQTMAPVAFWVLNEDEdFKGGDYV 71  Salmonell...
WP_015225356        10 LASMTMGILS--------IGVEAIAQPEn---EPVSPINLEAITCRDLL----LMDGEEEENTILFMHGYMS-GEREETM 73  Halothece...
jgi:PCC8801_0830    10 ILVLTTVISG-------VGTSSSQAQEN----SGEMTVNLMEVTCRELF----KASAEDKDLILVFYHGLVT-AKKNQMV 73  Rippkaea ...
jgi:PCC7424_2053     8 LLALTLCFAE-------SVVLRSYAQDNaipnSAASSVDFSKIDCETLL----KMDGDERDYTIIFFQGFMS-GRRNTMI 75  Gloeothec...
jgi:Bind_1699        1 mrKLALFAAA-------MMTISAIPAKA------QVMIDMSLVTCKQFL----DSDAERAAILASWMGGYFS-ASKNLST 62  Beijerinc...
Q89I73               6 kTMLSILFAA-------ALSLSSMPAHA-------VKWDLSTMTCRQFL----ESGEDNIAVVLTWMDGWYK-GDEDNAI 66  Bradyrhiz...
gigasnome:DGI_2961   7 TAMIAASLVA-------LCASPAMAKKQ----GI-QDIDFSQITCGDFVadlqTASAEDVGVIFMWLDGYLS-GVSGDTT 73  Desulfovi...

jgi:Aave_0086       87 FEEDAIEKIKPELDQYCSVHLTKSAYA 113 Acidovorax citrulli AAC00-1
WP_004236529        67 ALSEKGVAEAPKIVEFCKKFPEGTLQD 93  Morganella
P0AET2              71 TLNETDLTQIPKVIEYCKKNPQKNLYT 97  Escherichia coli K-12
Q7CQI8              72 DFQETETTAVPLAVELCKKNPQSELSK 98  Salmonella enterica subsp. enterica serovar Typhimurium
WP_015225356        74 IDIGKLIAVTDQVKNTCIDEPSNELMQ 100 Halothece sp. PCC 7418
jgi:PCC8801_0830    74 IDRTQLEQATDKITDYCIDNPKATLMT 100 Rippkaea orientalis PCC 8801
jgi:PCC7424_2053    76 VDELAFARATDEVIDYCVDNPNDRVIs 102 Gloeothece citriformis PCC 7424
jgi:Bind_1699       63 VDLRYVERNTKKVINYCEANKSKTLMS 89  Beijerinckia indica subsp. indica ATCC 9039
Q89I73              67 IDTEVFIENAKKFGAYCGKNPTVSVVt 93  Bradyrhizobium japonicum
gigasnome:DGI_2961  74 LRWDGMQDFGTNLVDLCKKKPRMKVLD 100 Desulfovibrio gigas DSM 1382 = ATCC 19364
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