2P01


Conserved Protein Domain Family
Alpha-2-MRAP_C

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pfam06401: Alpha-2-MRAP_C 
Alpha-2-macroglobulin RAP, C-terminal domain
The alpha-2-macroglobulin receptor-associated protein (RAP) is a intracellular glycoprotein that binds to the 2-macroglobulin receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of all currently known ligands of these receptors. Two different studies have provided conflicted domain boundaries.
Statistics
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PSSM-Id: 399417
Aligned: 30 rows
Threshold Bit Score: 185.533
Threshold Setting Gi: 390354231
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2P01_A       112 LDDPRLEKLWHKAKTSGkFSGEELDKLWREFLHHKEKVHEYNVLLETLSRTEEIHENVISpSDLSDIKGSVLHSR-HTEL 190
XP_006629679 136 FDDPRLEKLWNKAKTSGkFSEEELKNLQREFQHHQEKIQEYNIVMDAVSRTEEIHKNVISpVE-ADVKTHALHEK-HADL 213 spotted gar
CAG03288      98 FDDPRLDKLWNRAKSSGkFTDEELLNLKREFQHHKDKIHEYNILMDAASRTEEIHKNLISpLE-GDTKEPELHKR-HTDL 175 spotted green p...
NP_958463    119 FDDPKLDKLWNKARTSGkFSDEELQTLHREFQHHKDKIHEYNIVMDTVSRTEEIHKNVISpLE-GDVKENVLHQK-HTDL 196 zebrafish
XP_001373270 154 LDDPRLEKLWNKAKTSGkFSSEELDKLWREFKHHKEKVHEYNVLLETVSRTEESHKNVISpLEENHVKEDVLHSK-HTEL 232 gray short-tail...
Q148K7       151 LEDPRLEKLWHKAKTSGkFSSEELDKLWRELQHHKEKVQEYHALLETLGGAEESHENAIGpVDLRGVQAEALASR-HAEL 229 cattle
2_pfamImport   1 FQDPQLNKLWLQTVSSKkFKTDELDKLLVEFKHHEDKVWELDELRKDLERVRA-----ISeNSVERFNDKQDQVKrEAEA 75 
XP_002127747 120 FQDPQLNKLWLNTAASKkFKNEEMEKLFIEFKHHEDKIWELNSLHKDLEKMKA-----ISeNSVERFLDSDEEKKkEKYV 194 vase tunicate
XP_008149118 151 LEDPRLEKLWHKAKTSGkFSRDELDKLWREFQHHREKVREYNVLLETLSRTEEIQENAISpSDMRRPQEEVLQSR-HADL 229 big brown bat
AAI58918     135 LNDPRLEKLWNKAKTSAkFSEEELESLWRELAHHKEKIDEYNILLDTVSRTEEIHKNVISpEE-HEIKEDILHAK-HTDL 212 tropical clawed...
2P01_A       191 KEKLRSINQGLDRLRRVSHQGYsTEAEFEEPRVIDLWDLAQSANLTDKELEAFREELKHFEAKIEKHNHYQKQLEIAHEK 270
XP_006629679 214 KEKMRNLNQGFERLRKISHQGFnEDSEFKEPRVIELWDMAKRANFTEDELDTLKEELSHFQTKVEKHQHYQEQLELSHQK 293 spotted gar
CAG03288     176 KQKMRDINHGFERLRKLSHEGFtEDSEFREPRVIELWEAAKRANLSKDELDSLKEELHHFETKVEKHSHYQEQLELSHQK 255 spotted green p...
NP_958463    197 KQRMRDLNQGFERLRKITHEGYtDDSEFREPRVIELWEMAKRSNLSEDELDSLKEELRHFETKVEKHQHYQEQLELSHQK 276 zebrafish
XP_001373270 233 KDKLRSINQGFDRLRKVSHQGYdTNSEFEEPRVIDLWDMAKTANFTQKELDSFREELKHFEAKIEKHHHYQKQLEISHQK 312 gray short-tail...
Q148K7       230 KDRLRSIGQGFDRLRRVSHQGYgAETEFTEPRVLDLWDMAKSANFTEKELESFREELKHFEVKIEKHNHYQKQLEISHQK 309 cattle
2_pfamImport  76 KTLQEEVETSFQRLHLVAQKSKdENVAFIEPRVAELWEMAQNGNFTVVELLSVKQELHHFENRINKHKHFRDQLKNSAEK 155
XP_002127747 195 EELQQELENSFERLHRVTLKSTdEKVDFIEPRVAELWEMARNGNFSEDGLASVRQELHHFENRITKHRHFREQLKNSAEK 274 vase tunicate
XP_008149118 230 KDRLRRISQGYDRLRRVSHQGYgAEAEFEEPRVIDLWDLARSANFSEKELEAFREELKHFEVKIEKHNHYQKQLEISHQK 309 big brown bat
AAI58918     213 KERLRSINQGYERLRKLSHEGFiTAREFNEPRVNDLWDMAKDANFSDSELESFKEELKHFETKIEKHQHYQKQLEISHEK 292 tropical clawed...
2P01_A       271 LR-------HaesvgdgERVSRSREKHALLEGRTKELGYTVKKHLQDLSGRISr--aRHNEL 323
XP_006629679 294 LKhvealgdK-------EHIQRNKDKYDMLSEKTREIGYKMKKHLQDLTSKITrtglRHNEL 348 spotted gar
CAG03288     256 LQhvealgdH-------EHIRKTQEKYNTLAEKTREIGYKMKKHMQDLSSKISrqglNHNEL 310 spotted green pufferfish
NP_958463    277 LKhvealgdE-------DHIMRNKEKYNTLAEKAREMGYKMKKHLQDLTNKLSknglQHNEL 331 zebrafish
XP_001373270 313 LKhvegtgdK-------EHLSRNKEKYAMLEEKTKELGYKVKKHLQDLSTRISrg-lSHNEL 366 gray short-tailed opossum
Q148K7       310 LKhvesfgdQ-------EHVTRNRERYATLEERTKELGYKVKKHMQDLSSRISr--aRHNEL 362 cattle
2_pfamImport 156 LDfh----gE-------GATEERVSRHQKLQGKVQDLGTKVKKLFGDLKSRLStv-iKHKEL 205
XP_002127747 275 LDfh---ggE-------SAPDDRVVKHQKLQDKVQDLGNKVKKLFGSLKSRLSngviTHKEL 326 vase tunicate
XP_008149118 310 LRhverfgdH-------EHVSRNKERYAMLEEKTKELGYKVKKHLQDLSGRISr--aRHNEL 362 big brown bat
AAI58918     293 LKhvaetgdK-------EHIMRSKEKHSMLTDKIKELGYKVKKHLQDLTSRASrgglRHNEL 347 tropical clawed frog
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