Conserved Protein Domain Family
Alpha-2-MRAP_N

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pfam06400: Alpha-2-MRAP_N 
Alpha-2-macroglobulin RAP, N-terminal domain
The alpha-2-macroglobulin receptor-associated protein (RAP) is a intracellular glycoprotein that binds to the 2-macroglobulin receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of all currently known ligands of these receptors. The N-terminal domain is predominately alpha helical. Two different studies have provided conflicted domain boundaries.
Statistics
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PSSM-Id: 399416
Aligned: 22 rows
Threshold Bit Score: 115.087
Threshold Setting Gi: 390354231
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002430317  10 IVLTMVDFGKTISKYSAEANLKPpdkpwvlnpNVNFRTLD------KPFRMAKLNLLWSKAQR-RLTDVKLKSLFSDL-- 80  human body louse
EFX84118       8 FLLGLSYCQAAVNKYSKEANQPEpvegv---dkdswKSID------KPFRLAKINLIWAKAQK-RLTEFKLKSLYSEL-- 75  common water flea
XP_800714     11 ILAFAIANVMAADKYDRKSNRVD---------RPDLDKMDkssmmgREFKSRQVIQVWQKADRmNLAQTKMKDLHRELlr 81  purple sea urchin
XP_005797298   7 VAALWLGVGVMAGKYSREVNEPT---------QSDGGGQT------AEFRIAKLNQVWEKAKRmQLTPVRQAELHSDL-- 69  southern platyfish
Q148K7        25 LLLGPWAAAGHAGKYSREKNEPA---------PPSKREPA------AEFRMEKLNQLWEKAQRlNLPPLKLSDLHTDL-- 87  cattle
XP_018880773  21 LFLGPWPAASHGGKYSREKNQPK---------PSPKRESG------EEFRMEKLNQLWEKAQRlHLPPVRLAELHADL-- 83  western lowland...
Q99068        24 LLLVPQPIAGHGGKYSREKNEPE---------MAAKRESG------EEFRMEKLNQLWEKAKRlHLSPVRLAELHSDL-- 86  Norway rat
NP_990393     10 VMAAFLAVSTRASKYTREANEGL---------ADAKRREA------GEFRVVRLNQVWEKAQRlQLSAVKLAELHSDL-- 72  chicken
AAI58918      11 VLLLRAQAGDGAGKYSRNVNENR-----------SERDPT------VEFRIMRLNQIWEKAQRlQLPAVQLAELHSDL-- 71  tropical clawed...
XP_026104230   7 ILISLFVIGAMAGKYSKEMNEQQ---------ASDKNNNQ------VEFRIAKLNQVWEKAIRmQLAPVRLSELHSDL-- 69  goldfish
XP_002430317  81 ---KIHDKEEIAWKRFKSDGNDKDGLKEAELREKLIGIMSTYSLLEHFQDVNDP 131 human body louse
EFX84118      76 ---KVQDKEELQLKRLKADNLDKDGLKEAEIRKKFGNVIERYGLADHFDKdtes 126 common water flea
XP_800714     82 vdgMYHKMKKESTAKQPDNRIKSEKETEMTIQRQIGEIMRKYGM----AGGADr 131 purple sea urchin
XP_005797298  70 ---KIQEKDELQWKKMKVEGLDENGEKEAQLRRNFNVILAKYGM----DGKRDM 116 southern platyfish
Q148K7        88 ---KIQERDEFKWKKLKAEGLDEDGEEEAKLVRSLSVILAKYGL----DGRKDS 134 cattle
XP_018880773  84 ---KIQERDELAWKKLKLDGLDEDGEKEARLIRNLNVILAKYGL----DGKKDA 130 western lowland gorilla
Q99068        87 ---KIQERDELNWKKLKVEGLDGDGEKEAKLVHNLNVILARYGL----DGRKDT 133 Norway rat
NP_990393     73 ---KIQEKDELSWKKLKAEGLGEDGEKEAKLRRNINVIMTKYGM----NGKKDS 119 chicken
AAI58918      72 ---KIQEKDELNWKKLKVEGLDDDGEKEAKLRRSLNVILAKYGL----DGKKKS 118 tropical clawed frog
XP_026104230  70 ---KIQEKDELQWKKLKAEGLDEDGEREAKLRRNFNIILAKYGM----DGKKDT 116 goldfish
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