Conserved Protein Domain Family
CD34_antigen

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pfam06365: CD34_antigen 
CD34/Podocalyxin family
This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighboring foot processes in the glomerular epithelium by charge repulsion.
Statistics
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PSSM-Id: 399394
Aligned: 19 rows
Threshold Bit Score: 143.695
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_010588581 193 CLEQNETSRCEDFKK-DKGEDLVQILCDEKEQ---AGAEVCSLLLAQSEIKPQCLMLFLPNRT---ELPSKLQFMEKHRF 265 African savanna...
XP_015203509 346 ILNMSENVDCDTFRV-ESGDRLLEMLESAFSRkmnSPQGSWFISLTKPNRQDKQLLMTLASEQgviPTKEVLSMLGEIRR 424 spotted gar
XP_005992594 352 ILNVSHNMDCEDFRL-QNGARFLSLVGRAFSRrteRPQESWRILLSKPNEDDSRLLMTLTGEQgviPVKDLLAAMRDINR 430 coelacanth
XP_019475522 442 ILNMSDNIDCEEFRL-ERGPQLLALVEDAFSRhadGLQDHWMISLSKPNENDKHLLMTLAGEQgviPTKDVLMALGDVKR 520 turkey
XP_017740628 329 ILNMTENIDCEVFRQ-HRGPQLLALVEEVLPRhgsGHHGAWHISLSKPSEKEQHLLMTLVGEQgvvPTQDVLSMLGDIRR 407 black snub-nose...
NP_001258823 373 ILNLKEEKTCDDWKK-ASNEAFFEVFCSGRRHafnSTRDRCTVKLAS--SNHRRWAVHVIVHRv-lDPAAVFEELKEKRN 448 chicken
XP_007504399 391 ILKMTNFTMCDSPKD-SRNHPLYVALCRAGKVnfnKDRDVCHVQLVPQPEKQEVAILNVSVQTh-lQPKELFEVLKKRWD 468 gray short-tail...
XP_021586049 355 ILNLTETSPCAKSP--PADDKLITQLCQAVKAtfnPAQDSCTVQLAPIQESQAVALKKITIQTn-lLPENVYALLKDKWD 431 thirteen-lined ...
4_pfamImport   1 -LKLKASSTCKDTK--EKIGSVLQELC----------GDGCKLDIYQEDDSDQIIV----------SGKYVEEDVAGMAD 57 
XP_030145899 352 tiQLKEPRTCEEWKTaSKNNSFFESFCSTAQHvfdGSRDRCRVTLMACKSPSRRWAVQVVLHLp-lDSEEVLMKLKEKKE 430 zebra finch
XP_010588581 266 DLQKLGIRDFT------EENVLSHQ--SHSRKTLIAVVTSGILLAILGTTGYF--LMNRRSWNPAG-------------- 321 African savanna...
XP_015203509 425 SLYEIGIQNYTsvtscqSQPSQTRS--DYGKLFVVLVIIGSVCVVIIVSGLIYicWQRRLPKLKNM-------------- 488 spotted gar
XP_005992594 431 DLQEVGIQNFTaaaacqSKVNPSRS--DYGKLFVVLVIIGSICVIIIVVGLVYicWQRRLPKLKAM-------------- 494 coelacanth
XP_019475522 521 SLAEIGIQNYStttscqSHPNQTRS--DYGKLFVVLVIIGSICAIIIVLGLIYncWQRRLPKMKNM-------------- 584 turkey
XP_017740628 408 SLEEIGIQNYSttsscqARASQVRS--DYGTLFVVLVVIGAICIIIIALGLLYncWQRRLPKLKHV-------------- 471 black snub-nose...
NP_001258823 449 ELEKLGITNVTylnqemEEE--IKD--QFSTPLIITIVT--LAGSLLLIAAIYgcCHQRFSQKKSQ-------------- 508 chicken
XP_007504399 469 DLKALGVSNMTygkeslDKD--EED--RFSLPLIITIVC--MAAFLLLVAALYgcFHQRFSQRKDQ-------------- 528 gray short-tail...
XP_021586049 432 DLREVGVSHMQlgdegpPEE--AED--RFSMPLIITIVC--MASFLLLVAALYgcCHQRLSQRKDQ-------------- 491 thirteen-lined ...
4_pfamImport  58 RFNNDNIKDKTdvqeavPRWGREEEggKNSKLVLVSLLLTGLLLAALLVAGYYfkTHRRTSK---G-------------- 120
XP_030145899 431 RLEQLGIINITsd--kmVEDMTIND--EFSTPLIITIIT--LAGSLLLVAAIYg-cHQRFSQKKDQnihpdvpgfddghv 503 zebra finch
XP_010588581 322 -----ERlGEEPYHSESGG-GQG-YSSSPGASPEAQGK-AIVNQGAQENGT--GQAT----SRNGHSARQHvVADTE 384 African savanna el...
XP_015203509 489 -----SH-GEELHFVENGChDNPtLDVASDSQSEMQEKkPSVNGV-AVDGG--GSWHvl-vNKSAKEDAENlEEDTH 555 spotted gar
XP_005992594 495 -----SH-GEELHFVENGChDNPtLDVTIDSQSEMQEKqQSVNGG-ALDGP--DSWSvl-vNRRAVDEAETlEEDTH 561 coelacanth
XP_019475522 585 -----SH-GEELRFVENGChDNPtLDVASDSQSEMQEKkPSVNGGNTINGP--DSWDvl-iNKQASEDVDVfEEDTH 652 turkey
XP_017740628 472 -----SH-GEELRFVENGChDNPtLDVASDSQSEMQEKhPSLNGGGALNGP--GSWGalmgGKRDPEDSDVfEEDTH 540 black snub-nosed m...
NP_001258823 509 -----QRlTEELQTMENGYhDNPtLEVME-TGSEMQEK------KVNLNGElgDSWIvp-lDTIMKEDLE--EEDTH 570 chicken
XP_007504399 529 -----QRlTEELQTVENGYhDNPtLEVME-TSSEMQEK-----KVANLNGElgDSWIvp-lDNLTKDDLDQeEEDTH 593 gray short-tailed ...
XP_021586049 492 -----QRlTEELQTVENGYhDNPtLEVME-TSSEMQEK-----KVVNLNGElgDSWIvp-lDNLTKDDLD--EEDTH 554 thirteen-lined gro...
4_pfamImport 121 -----IRlAESFQVDEENq-ANTlVSVAP-LPQEPHDKpTAIGETPPENGT--SAAP----ATNGHSATQTpVADTE 184
XP_030145899 504 alifnQRlTEEMQTMENGYhDNPtLEVME-TSSEMQEK------KVNLNGElgDSWIvp-lDTLMKEDLEe-EEDTH 571 zebra finch
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