3OBV


Conserved Protein Domain Family
Drf_DAD

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pfam06345: Drf_DAD 
DRF Autoregulatory Domain
This motif is found in Diaphanous-related formins. It binds the N-terminal GTPase-binding domain; this link is broken when GTP-bound Rho binds to the GBD and activates the protein. The addition of DAD to mammalian cells induces actin filament formation, stabilizes microtubules, and activates serum-response mediated transcription.
Statistics
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PSSM-Id: 399385
Aligned: 3 rows
Threshold Bit Score: 34.6056
Threshold Setting Gi: 312597469
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3OBV_E    428 GVMDSLLEALQSGAA 442 
KRG03479 1031 GVMDSLLEALQTGSA 1045 Drosophila mojavensis
O70566   1051 GVMDNLLEALQSGAA 1065 house mouse
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