Conserved Protein Domain Family
CNDH2_N

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pfam06278: CNDH2_N 
Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
CNDH2_N is the N-terminal domain of the H2 subunit of the condensing II complex, found in eukaryotes but not in fungi. Eukaryotes carry at least two condensin complexes, I and II, each made up of five subunits. The functions of the two complexes are collaborative but non-overlapping. CI appears to be functional in G2 phase in the cytoplasm beginning the process of chromosomal lateral compaction while the CII is concentrated in the nucleus, possibly to counteract the activity of cohesion at this stage. In prophase, CII contributes to axial shortening of chromatids while CI continues to bring about lateral chromatid compaction, during which time the sister chromatids are joined centrally by cohesins. There appears to be just one condensin complex in fungi. CI and CII each contain SMC2 and SMC4 (structural maintenance of chromosomes) subunits, then CI has non-SMC CAP-D2 (CND1), CAP-G (CND3), and CAP-H (CND2). CII has, in addition to the two SMCs, CAP-D3, CAPG2 and CAP-H2. All four of the CAP-D and CAP-G subunits have degenerate HEAT repeats, whereas the CAP-H are kleisins or SMC-interacting proteins (ie they bind directly to the SMC subunits in the complex). The SMC molecules are each long with a small hinge-like knob at the free end of a longish strand, articulating with each other at the hinge. Each strand ends in a knob-like head that binds to one or other end of the CAP-H subunit. The HEAT-repeat containing D and G subunits bind side-by-side between the ends of the H subunit. Activity of the various parts of the complex seem to be triggered by extensive phosphorylations, eg, entry of the complex, in Sch.pombe, into the nucleus during mitosis is promoted by Cdk1 phosphorylation of SMC4/Cut3; and it has been shown that Cdk1 phosphorylates CAP-D3 at Thr1415 in He-La cells thus promoting early stage chromosomal condensation by CII.
Statistics
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PSSM-Id: 399346
Aligned: 29 rows
Threshold Bit Score: 90.7525
Threshold Setting Gi: 675886368
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006349825  23 VQPLRDLESNWGVDLAKNLEEYLLKIcSGEITSEnydD---------GHHLS-VNFAEAALLLQGSVQVYSRKVEYLYSL 92  potato
2_pfamImport   2 LQPIRDLSKNWNIDLASELEEYMDKL-ENLSIAF---DpedgasidrDGDSV-MNFAEAALLIQGTSVIYSRKVEYLHAL 76 
CBJ29522     121 LQPIRDLAQNWDVDIATSLEDYLEDL-EHITITL---D---------GGASK-VNFAEAALLIQGSTCVYSRKVEHVYQL 186 Ectocarpus sili...
EEC43358      23 LQPIRDLAKNWDIDIASCLEEYLHDLgDDLALAD---P---------NGQLDkLNFAQAALVLQNSSHVYSRKVEYLYSL 90  Phaeodactylum t...
ERN03322      11 LQPNRDLESNWALDVAKQLEEYLLEIcLGPDLAN--------------GHVP-INFAEAALLLQGSIQIYSRKVEYLYSL 75  Amborella trich...
EEF45573      17 VQAERDLEANWDVDLAKKLEDYLLKLcSGEITSD---D-----------NVS-VNFAEAALLLQGSVQVYSRKVEYLYNL 81  castor bean
XP_009114535  13 VQPERDLVANWEVDLSEKLEEYLLKIcSGEITGT---E---------E-DSP-VNFAEAALLLQGSVQVYSKKVEYLYNL 78  field mustard
KRH12083      19 VHAERDLESNWEVDLAKKLEEYLLKIcSGEIIGE---E---------EGHSH-VNFAEAALLLQGSIQVYSRKVEYLYTL 85  soybean
XP_014753512  20 LQANRDPESNWELDVAKSLEEYLLKIcSGEISGE---D---------G-AHN-VNFAEAALLLQGSVQVYSRKVEYLYSL 85  stiff brome
XP_009028686  18 LQPVKDLSKNFNIDLNLHLEEYLLELeSGILSQRkgfD---------G-----VDFIEAALIIKGSASIYAKKVDYLYQL 83  Helobdella robusta
XP_006349825  93 VVHALE----FITKKSE---PDLPASGSAQADENG-LPAANHEE-DDPFWV 134 potato
2_pfamImport  77 VFQTLA----HLSKQQDdkpQNQQNGEPIDGQDEEeNDDAEAG-------- 115
CBJ29522     187 VQRTID----FLTQQKQ---QNNNNAAKSKSGDGDvGDDSIMGGdETAFLP 230 Ectocarpus siliculosus
EEC43358      91 VYKALD----DLVAQNA---ASLSNMRRSKHGDSEiDDFREFDP-HSDFLL 133 Phaeodactylum tricornutum CCAP 1055/1
ERN03322      76 VLHALE----FISQKSR---QDQQEKSSIHPDGSD-ADAIVDDE-NEEFLS 117 Amborella trichopoda
EEF45573      82 VLHALD----FLSQKRQ---QEQTEGTSFQPEQNG-SNAASDEE-SDQFWV 123 castor bean
XP_009114535  79 VLRTLE----FLSNQRE---QEESKGTSHEAEASS-SRQADEEE-NDLFWN 120 field mustard
KRH12083      86 VLRALE----FLSQKRQ---QDHKDGPSVQPEESG-PCAVTDEE-NDQFWG 127 soybean
XP_014753512  86 VLNALE----FLSQNKQ----DQQQKGSAEANEND-PSITPNEE-DDMFVG 126 stiff brome
XP_009028686  84 TQLAINtlngIVSNKKKsdeKPNSAGQSSVGLE------------ETKFLA 122 Helobdella robusta
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