Conserved Protein Domain Family
HTH_42

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pfam06224: HTH_42 
Winged helix DNA-binding domain
This family contains two copies of a winged helix domain.
Statistics
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PSSM-Id: 399316
Aligned: 79 rows
Threshold Bit Score: 115.092
Threshold Setting Gi: 283949232
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Elen_1142     31 LAGACGMQNTP----PGAWETALFNRAPACRREDAERLlYGEKTLVQAWSLRGApvVFPAAESAAFLSALVPAKGEPwaY 106 Eggerthella...
Q5WJW8            29 LNGLEAIQLDPvaviERNHHLTASLRMKRYDPAELEQL-LEKQQAFEYYAQAAC--LLPIADFPLFEDVRQRLLTA---- 101 Bacillus cl...
Q67LZ2            44 LERLEAVQLDPiavvERNHHLVLRNRVGGYRPEHLDGL-FAAGQVFEYLANARC--VLPMRDLPDFWPIMLAA------- 113 Symbiobacte...
mpitm:STAUR_1846  53 LRQLRHIQLDPldviGTNADLVALARVDEIARGDVYRH-LYPGHAFEHWAKERC--LLPASAFAHYRERSLEAPWWR--- 126 Stigmatella...
Q2IPP1            35 LERLRCIQLDPldplGTNADLVALARVDGIAKGDVYRH-LLPGHAFEHFAKERC--LLPAGAFPWYRAELAIEAPWW--S 109 Anaeromyxob...
WP_012199889      37 FNRVGSIQYDPlnvvGRNADLVLQAKVKGYQSNHLETLlYKDYKLVDGFDKEMC--IYQIEDYNNFQRVREATARATkcV 114 Lachnoclost...
WP_011761208      35 IARLGYVQIDSiqvaARAHDHVLHSRLADFRPEALAGA-VADKSIFEYWSHAAA--YLPMRDYRFSLPRKLALRNGE--- 108 Shewanella ...
Q12J09            34 VTRLSYVQIDSinvvERAHHHVLHTRLNNYQPSTLNQA-LADAQIFEYWAHAAA--YLPIEDFRFSLQRKLALQQGG--- 107 Shewanella ...
Q8E9F2            31 IACLGYVQIDSinvvERAHHHVLHSRMPQYQPQMLDTA-LAQGEIFEYWSHAAA--YLPIADYRFSLQRKQQLQNGG--- 104 Shewanella ...
Q6MJV3            37 IKHLGYVQIDTinviERSHHHILFSRIPDYRRLHLHQAqSKDKTIFEYWTHALA--YIATDDFKYFINDMNRRKANP--- 111 Bdellovibri...
jgi:Elen_1142    107 TkgiglaLDALGMEFDRL-LELLVRAMprlDDEAIASKVALDQTLADwvepllpankraawrqpsMYGSPDKQTVGGAAV 185 Eggerthella...
Q5WJW8           102 -------CASDLSAHKDA-IRVIFNRLa--TEGPLASNAFQSERKVIggwd-----------tnsASTKETSHALQLLFL 160 Bacillus cl...
Q67LZ2           114 -------RQLPARAALADvMTDVLRRLy--REGPLPPRALGNDGPRLlglgy---------nppdKASKASGRAIDLLWL 175 Symbiobacte...
mpitm:STAUR_1846 127 -------HVTRLQRLPASvLRAVLEELe--AHGPLSAAELTDHGAVEpldw----------sgwkGTAKATSMALEVLWT 187 Stigmatella...
Q2IPP1           110 -------HAERLRRLPPGvVEKVLDEVr--ARGPVAADDLTDHGPVErldw----------sgwkGTPRAAKMALEVLQT 170 Anaeromyxob...
WP_012199889     115 L------SNRNQLEAFEY-LEVVKEHIn--THGITSTKDISIGESStsrw---------------ghkkLSSATLDYLYS 170 Lachnoclost...
WP_011761208     109 -------RHWFERDSRE--MREVLSRIr--AEGPLKASDFEAP-PGKagaw--------------wdwkPAKKALEQLFM 162 Shewanella ...
Q12J09           108 -------KHWFEVDDKA--MQEVLARIt--TEGPLKSSDFKHPESNKtsgw--------------wdwkPAKKALEQLFM 162 Shewanella ...
Q8E9F2           105 -------KHWFEPDDNA--MQEVRARIr--AEGPLKASDFEHTEGKNgaww---------------dwkPAKKALEQLFM 158 Shewanella ...
Q6MJV3           112 -------SEWYSSVTEKD-VKGILATIk--KQGPISIRDVTDDVLVEkthaw-------------askkPSKKFLQCGFN 168 Bdellovibri...
jgi:Elen_1142    186 SFLLRPCSfMGLVVfgeragatPTFTSYRRWtgga--------------------------------------------- 220 Eggerthella...
Q5WJW8           161 TGQIQVVKrQ-GAK--------RFFALTEDAipnhyl------------------------------------------- 188 Bacillus cl...
Q67LZ2           176 GGEVFVARrE-GNE--------KWYDLAERViprnvaadlpgdfsnlrspmlrahagvgaegqetgperagdsahgagar 246 Symbiobacte...
mpitm:STAUR_1846 188 RCDIVVCGrSPGG---------KRYDVPHRAlpdvara------------------------------------------ 216 Stigmatella...
Q2IPP1           171 RCEVVVCGrSARG---------KVYDVPERAlpgaaga------------------------------------------ 199 Anaeromyxob...
WP_012199889     171 SGELFVVNkK-GVQ--------KYFDLTENVlskefln------------------------------------------ 199 Lachnoclost...
WP_011761208     163 EGDLMVARrD-GFQ--------KVYDLTERVlprgvd------------------------------------------- 190 Shewanella ...
Q12J09           163 QGDIMVKRrD-KFQ--------KVYDLTERVlpssvn------------------------------------------- 190 Shewanella ...
Q8E9F2           159 RGELMVVRrE-KFQ--------KCYDLTERVlpshin------------------------------------------- 186 Shewanella ...
Q6MJV3           169 GGDLVIAErQ-GML--------KKYDLTDRHfawdkr------------------------------------------- 196 Bdellovibri...
jgi:Elen_1142    221 ---------------------------------lqpdADAA------ARLVRKFVHCYG-PTRPDALAAWTG--CSgaQA 258 Eggerthella...
Q5WJW8           189 --------------------------------ksplsTQERt-----RALLLKYARAYR-LFSADDPRYGWQk-HRaaMR 229 Bacillus cl...
Q67LZ2           247 geggggegerralpgdspvltgvdvsrpwstpdvgagEAEWq-----RFLLDKYMRAYR-LVDLGDFRFGWQs-YPsaRR 319 Symbiobacte...
mpitm:STAUR_1846 217 -------------------------------spgdttEEGFl-----RWALGERVEAAG-LLSRGAGAHWSM--LSpvRG 257 Stigmatella...
Q2IPP1           200 ------------------------------rvhprgrSRARraeafhRWAVVERVEAAG-LLSTAGGATWSM--LEpaRR 246 Anaeromyxob...
WP_012199889     200 -------------------------------kdkmksDEEFl-----KWYIKRRIRSVGfLWDKRGGAWQGHyiSDrkTR 243 Lachnoclost...
WP_011761208     191 --------------------------------drvpsDDEYg-----RYLVQSFLRAHG-HGSLAEICYLRR--NVkpLV 230 Shewanella ...
Q12J09           191 --------------------------------rqaptEDEFa-----HYLISRFIRAQG-VGTLKEIGYLRK--GLkpAL 230 Shewanella ...
Q8E9F2           187 --------------------------------tlapsDSEFa-----RHLISRYLDAHA-FGSAAQIAYLRK--GIkaNV 226 Shewanella ...
Q6MJV3           197 --------------------------------pkaatPAEVc-----EYYIDRALRSQG-VISLDSAAYMAKapFKkeIL 238 Bdellovibri...
jgi:Elen_1142    259 RRMWKGIAdElEPVEFG---------GKK--AWALAAdldaLASAEPPERe--vLLLAGHDPY-LDQRDRATLQvDVsLQ 324 Eggerthella...
Q5WJW8           230 KKWHAQLVeEgVLTEVAiegvkrpyaVLStdVDELL-----SHSDNQPKGi---AFLSPLDPLlWRRERLQDIY-DFhYR 300 Bacillus cl...
Q67LZ2           320 RALAAEKVaKgEWVEVEvdgv-------rrrYFALAEdrpcLEVAGDWEPrrtvRFLAPLDNLlWRRERLQDLF-DFdYT 391 Symbiobacte...
mpitm:STAUR_1846 258 SALPDTLVrEgVLEEVVlpg--------atrRYLAPAgfrsRPVTAPDTRm---RILGPLDPLlWDRTLVKQLF-GFeYI 325 Stigmatella...
Q2IPP1           247 ARLPEALVsEgAVEAVQvag--------srrTFLAPRgfagRRHPPPDGRv---RLLGPLDPLlWDRGLVRAAF-GFdYT 314 Anaeromyxob...
WP_012199889     244 TEVLSNLVsEgELIAFHiegi-------detFYMVAEderfFNQPPAKKQv---KFLAPLDNMlWDRDLVSTLF-DFdYR 312 Lachnoclost...
WP_011761208     231 KRVIADMLeNgELSSFIsdg---------kpRYYRRNia-pVPLPSRv------WLLNPFDNLlIQRNRLKQWF-DFdYQ 293 Shewanella ...
Q12J09           231 TRQIQNLLeAgSLSHFSqlg---------qdYYFDPNiglkKVKKSKv------FLINPFDNLiIQRARLTQLF-DFnYV 294 Shewanella ...
Q8E9F2           227 NQQLAAMQsQgELASFKaeg---------qwYFYRPElqitAAMPNRv------WLLNPFDNLlIQRQRLKQWF-DFdYQ 290 Shewanella ...
Q6MJV3           239 KRIE-ARVkKgSLVPVQikgl------ekeaFWIEAEtl-dSEMPEANDMt---HILSPFDPLvIQRKRFHMFF-DYdHR 306 Bdellovibri...
jgi:Elen_1142    325 RRIWKtv------anPGVVVRNGEAVGTWTAKKKGAGLSVSLAT--WVAC-------------SEQKLRDLAEAYAAF 381 Eggerthella l...
Q5WJW8           301 WEIYTpkaarkvgsyGMPILWHGKLIGQISPLMNRETATLHIENi-VVEPsfkw------tptRKKAFAHALEQLAKR 371 Bacillus clau...
Q67LZ2           392 WEVYTpaakrrfgyyAMPILYGDRLIGRLDPKLDRENGVLVVNRl-QLELdgvd------rrgLETSLEKALYAFARW 462 Symbiobacteri...
mpitm:STAUR_1846 326 WEVYKpeaqrrwgwyVCPLLHQGQLVGRLEARVKE--DVLHVEKv-WREKgv---------klDDAALDEALARHAKA 391 Stigmatella a...
Q2IPP1           315 WEVYRpahlrrfgwyVCPLLQGDALVGRLDGAVRD--GALRVRAv-WVERga---------alDRADLLACLERHAAA 380 Anaeromyxobac...
WP_012199889     313 WEVYTpvikrkygyyVLPVLYGDKLVARFEPERVSYSEVFTIKNw-WWEDtiti------teeLIEEVHSAIQRFANY 383 Lachnoclostri...
WP_011761208     294 IEVYVpepkrrfgyySLGILWRDTFVGRVDVKADREKGLLRLRRl-TLEDaaydks--gslqpFLAPMEQALAEFCRF 368 Shewanella am...
Q12J09           295 LEVYVpeakrrfgyySLAVLWKDDFIAHLDVKAQRSHGHLLLQNl-SFTSkaltekamlhnddFFAAFEQAVNDYAEF 371 Shewanella de...
Q8E9F2           291 IEVYVpaekrqygyySLAILWRDRFVGRVDVKADRQSGLLLLQQl-TLEEgfdg-----mdegFCSAFEATVSEYARF 362 Shewanella on...
Q6MJV3           307 FEAYVpkekrkygyfALPVIIGDQAVTVIDLKADRQNQELLIQQwsWLGKnks--------kaNKTLIEQELHRFEKF 376 Bdellovibrio ...
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