Conserved Protein Domain Family
GDE_C

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pfam06202: GDE_C 
Amylo-alpha-1,6-glucosidase
This family includes human glycogen branching enzyme Swiss:P35573. This enzyme contains a number of distinct catalytic activities. It has been shown for the yeast homolog Swiss:O93808 that mutations in this region disrupt the enzymes Amylo-alpha-1,6-glucosidase (EC:3.2.1.33).
Statistics
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PSSM-Id: 428822
Aligned: 11 rows
Threshold Bit Score: 494.932
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P35573 1042 LGSVQLCGVGKFPSlpilspalmdvpyrlneitkekEQCCVSLAAGLPHFSsgifRcWGRDTFIALRGILLITGRYVEAR 1121 human
Q06625 1045 MTSIQMVSRMKSTSil-------------------pGENVPSMAAGLPHFSvnymRcWGRDVFISLRGMLLTTGRFDEAK 1105 Saccharomyces cerev...
O62334  998 ISTLSFLGYIPGAGlapipt-----------slqieDQYPSSLAAGLSHFAvgiwRnWGRDTFIALPGCLLSTGRFQEAR 1066 Caenorhabditis elegans
Q9W2H8 1147 lSTLQFLSVCKSANlpgfspa---------lsppkpPKQCVTLSAGLPHFStgymRcWGRDTFIALRGSMFLTGRYNEAR 1217 fruit fly
Q9HL89  252 YNSLSFLMRH-------------------------------DMIAGFHWFG----P-WGRDTFISMPGVLLVSGRYNEAR 295  Thermoplasma acidop...
Q973T3  246 ISSTDFVVK---------------------------GKTGWSIIAGYHWFD----E-WGRDTFISMEGLLLLNRLFNQAK 293  Sulfurisphaera toko...
Q8TMM8  282 RATDSFVVKNH-------------------------ATGENTVIAGYHWYS----D-WGRDSMISLPGLLLIPYRFEEAR 331  Methanosarcina acet...
Q8XHY8  280 IAGDQFIVNRE-------------------------SIKGKTILAGYPWFL----D-WGRDAMIAINGLTLSTGRLEDAK 329  Clostridium perfrin...
Q9RXW4  327 VAADAYLVRRGQETkrgsgk----------ggaskgTPRGLSVIAGYPWFA----D-WGRDAMIALSGLTLVTGRFEDAR 391  Deinococcus radiodu...
Q8KPV1  289 LAADQFIVDRPLPN----------------------HPQGKSILAGYHWFA----D-WGRDTMISLPGLTLATGWPDLAR 341  Synechococcus elong...
Q8YNC7  310 KAGDQFIVYRD-------------------------SIAGPTVIAGYHWFN----D-WGRDTLIALPGLALVPQRFELAK 359  Nostoc sp. PCC 7120
P35573 1122 NIILAFAGTLRHGLIPNLLGE-GIYAR----YNCRDAVWWWLQCIQDYCKMVPNgLDILkcpvSRMYPtddsaplpa--- 1193 human
Q06625 1106 AHILAFAKTLKHGLIPNLLDA-GRNPR----YNARDAAWFFLQAVQDYVYIVPDgEKILqeqvTRRFPlddtyipvddpr 1180 Saccharomyces cerev...
O62334 1067 QIILSFAGAIRHGLIPNLLAE-GIGAR----YNCRDATWFWLVSIVKYVESAPNgVGILedpvRRIYPnddsvygeg--- 1138 Caenorhabditis elegans
Q9W2H8 1218 FIIIGFGQTLRHGLIPNLLDS-GSKPR----FNCRDAIWWWMYCIKQYVEDAPKgAEILkdkvSRIFPyddadahap--- 1289 fruit fly
Q9HL89  296 RVLEHYAERIQDGMIPNTQ---DVEAL----RFSADTSLWFIYAVQKYLEYAGD-DDFA----RQMLV------------ 351  Thermoplasma acidop...
Q973T3  294 DIILRYLDYESKGLLPNHITA-NGEPI----YVGVDVSLWAINSIYSYYLYSKD-KEFI----RKIYP------------ 351  Sulfurisphaera toko...
Q8TMM8  332 SALNNFARYCRRGLIPNTFPAfGGDPI----YNTVDASLWFIHALDRYFAYTQD-FLFL----SDVWD------------ 390  Methanosarcina acet...
Q8XHY8  330 DIIRSFSLYEKDGLIPNMFPGkGQEPL----YNTVDASLWFINAVYNYLLYANS-YEALefveKEVYK------------ 392  Clostridium perfrin...
Q9RXW4  392 ELLLTFLGQRRRGLIPNHFDEsGQGAG----YNTVARPLWLAVALERYARTTGD-ALFV----RQALP------------ 450  Deinococcus radiodu...
Q8KPV1  342 EILLTFAQFVSQGMLPNRFPD-DGNPLtdadYNTVDATLWYVEAVRQYLDCSGD-KTLL----AEIFP------------ 403  Synechococcus elong...
Q8YNC7  360 GLLQTFGRYCRHGLIPNAFPDiDSEPY----YNSIDAALWWIETLGLYLEATQD-WQFL----AEQFP------------ 418  Nostoc sp. PCC 7120
P35573 1194 -gtldqplfeVIQEAMQKHMQGIQFrernagpqidrnmkdegfniTAGVDEETGFVYGGNRFNCGTWMDkmgesdrARNR 1272 human
Q06625 1181 afsysstleeIIYEILSRHAKGIKFreanagpnldrvmtdkgfnvEIHVDWSTGLIHGGSQYNCGTWMDkmgesekAGSV 1260 Saccharomyces cerev...
O62334 1139 --evqqmlieTIYEALDKHFAGIDYrersagpqideqmrdegfqvTAGVSRTTGFIYGGNRWNCGTWMDkmgsserAGNK 1216 Caenorhabditis elegans
Q9W2H8 1290 -gafdqllfdVMQEALQVHFQGLQYrernagyeidahmvdqgfnnQIGIHPETGFVFGGNNFNCGTWMDkmgssqkAGNK 1368 fruit fly
Q9HL89  352 ----------PIKSIITAYIKGNS---------------------MFHLD-DDLVTLTGS---PLTWMD-------AMVS 389  Thermoplasma acidop...
Q973T3  352 ----------KLQDIVENYAKGNG---------------------VVYIK-EGLLFHRGA---PRTWMD-------ASYD 389  Sulfurisphaera toko...
Q8TMM8  391 ----------TVSSIIDNYCAGTDF--------------------AIGMD-SDYLIWQGP---QLTWMD-------AKVG 429  Methanosarcina acet...
Q8XHY8  393 ----------TIKNIIKAYKEGTKF--------------------SIKMDEEDSLINAGSGLDQVTWMD-------VRVN 435  Clostridium perfrin...
Q9RXW4  451 ----------MLRELLGSLVQGTDY--------------------GIGMDPADALLRAGEPGVQLTWMD-------VKIH 493  Deinococcus radiodu...
Q8KPV1  404 ----------VLQNIIGWHQRGTRF--------------------NIHLDPQDGLLTAGAAGVQLTWMD-------AKVG 446  Synechococcus elong...
Q8YNC7  419 ----------TVQQIYKAYFGGTRY--------------------NIQLDATDGLIGWDARNVALTWMD-------AVVG 461  Nostoc sp. PCC 7120
P35573 1273 GIPATPRDGSAVEIVGLSKSAV----RWLLELSKKNIFPyhevtv-krhgkaIKVSYDEWNRKIQDNFEKLFhvsEDpsd 1347 human
Q06625 1261 GIPGTPRDGAAIEINGLLKSAL----RFVIELKNKGLFKfsdve----tqdgGRIDFTEWNQLLQDNFEKRYyvpEDpsq 1332 Saccharomyces cerev...
O62334 1217 GEPATPRDGAAVELQGLAYRAL----KSLKNWKEQGVIQrsg--------vsDEWTWGFWAQKIRENFEKEFfvdKDsya 1284 Caenorhabditis elegans
Q9W2H8 1369 GRPSTPRDGSAVELVGLQYAVL----RFMQSLAEKEVIPytgverkgpsgevTKWSYKEWADRIKNNFDKYFfvsESetc 1444 fruit fly
Q9HL89  390 GKPVTPRIGKPIEINALWYNAL----SFYSRTAHDITGE-------------DTEMFSKLARRIKQKFRAKF-------- 444  Thermoplasma acidop...
Q973T3  390 SHVVTPREGAAVEINALWYNAL----MIMDFFAN-IVDD-------------KNSMYKELAEKTKASFNEKFissWG--- 448  Sulfurisphaera toko...
Q8TMM8  430 EWAVTPRAGKACEVNALWYNAL----KTASYMGT-LLGE-------------DISSYETLAAGVASNFENTF---WN--- 485  Methanosarcina acet...
Q8XHY8  436 GIVVTPRHGKPVEINALWYNAL----KIAALLKNKFEKE-------------EKNEYEELAKKVKDSFTKTF---WN--- 492  Clostridium perfrin...
Q9RXW4  494 DWVVTPRHGKPVEIQALWLAAL----GAELRLSQ-ALGE--------------PPRYAAVLERAHHSFKAQF---WNhaa 551  Deinococcus radiodu...
Q8KPV1  447 DWVVTPRIGKPVEINALWYAAL----RSLAHFAR-CLGQ-------------PSTDYDQLAEATLQGFQR-F---WQ--- 501  Synechococcus elong...
Q8YNC7  462 GEPITPRPGKPVEINALWYSALcwlsQWAERLSQMDLGDsvr-------lekQGRRYAQQAQQVKASLQK-F---WN--- 527  Nostoc sp. PCC 7120
P35573 1348 lne---------------------------------------------------------------------khpnlvHK 1358 human
Q06625 1333 dadyd------------------------------------------------------------------vsaklgvNR 1346 Saccharomyces cerev...
O62334 1285 ---------------------------------------------------------------------------efvNR 1289 Caenorhabditis elegans
Q9W2H8 1445 ---------------------------------------------------------------------------svaNK 1449 fruit fly
Q9HL89  445 ------------------------------------------------------------------------------IK 446  Thermoplasma acidop...
Q973T3      --------------------------------------------------------------------------------      Sulfurisphaera toko...
Q8TMM8  486 ------------------------------------------------------------------------------PE 487  Methanosarcina acet...
Q8XHY8  493 ------------------------------------------------------------------------------ED 494  Clostridium perfrin...
Q9RXW4  552 dltaaptatllglgqlgsslggalsdaldgdfvlddeprrdtssdalltvggrpgsgpvqsttgaselgvghrpgaapAQ 631  Deinococcus radiodu...
Q8KPV1  502 ------------------------------------------------------------------------------AD 503  Synechococcus elong...
Q8YNC7  528 ------------------------------------------------------------------------------PQ 529  Nostoc sp. PCC 7120
P35573 1359 RGIYKDSYGASSPw---CDYQLRPNFTIAMVV-----APELFTTEKAWKALEIAEKKLLGPLGMKTLDPDDMVYCGIYDN 1430 human
Q06625 1347 RGIYRDLYKSGKPy---EDYQLRPNFAIAMTV-----APELFVPEHAIKAITIADEVLRGPVGMRTLDPSDYNYRPYYNN 1418 Saccharomyces cerev...
O62334 1290 REIIKDSVGSTLGf---TDFQLRCNFGIALAV-----APDLMDPKKAWKALDSAE-VLLGPLGMKTLDPTDWAYNGYYNN 1360 Caenorhabditis elegans
Q9W2H8 1450 KLIYKDSYGATQSw---TDYQLRCNFPITLTV-----APDLCNPQNAWRALERAKKYLLGPLGMKTMDPEDWNYRANYDN 1521 fruit fly
Q9HL89  447 GDAVLDVSDP-------DDMKFRPNFLIPYFL-----PYPLLNDRK---FVDLAWEKLVTPYGLRTLSPDDPDYVPTYSG 511  Thermoplasma acidop...
Q973T3  449 ---AYDYLDPYLI----PDKSIRPNQLFALSL-----PFSIMSEDIGKIMLITIENELLRPFGLSTLSRRDPKYKPTYRG 516  Sulfurisphaera toko...
Q8TMM8  488 SNCLFDLIHQDEAgnqvKDPAIRPNQIFAVSL-----PYTMLSPEKEKAIVDRVEKDLLTPFGLKTLSSDHPLYKGQYRG 562  Methanosarcina acet...
Q8XHY8  495 RKYLYDVVNNHE-----KDDSLRPNQIWAVSL-----PFTMLDREKEKHIVQKVFEELYTPYGLRSLSRDNKDYHGIYIG 564  Clostridium perfrin...
Q9RXW4  632 PAVLADVIQPSGE----QDLSVRPNAVIALAL-----ADTPVVDEQLDAVLAQTERELLTPVGLHTLSPHDPRYLGNYGG 702  Deinococcus radiodu...
Q8KPV1  504 RGYCFDVLDSPTG----SDASLRPNQLLAISLgcdrdQPALLTPDQQQQVVTLCGQQLLTSFGLRSLDPRHPQYQGHYGG 579  Synechococcus elong...
Q8YNC7  530 LGYLYDTIDLDDR----RNVQIRPNAILALSL-----HHCGFSQQQGQQILDLATYCLLTPYGLRSLDPADPEYLGRYEG 600  Nostoc sp. PCC 7120
P35573 1431 ALDNDNYNlakgfnYHQGPEWLWPIGYFLRAKLYFSRLmgpETTAk--------tIVLVKNVLSRHYVHLERSPWKGLPE 1502 human
Q06625 1419 GEDSDDFAtskgrnYHQGPEWVWLYGYFLRAFHHFHFKtspRCQNaakekpssylYQQLYYRLKGHRKWIFESVWAGLTE 1498 Saccharomyces cerev...
O62334 1361 DDDGTDKKtakgwnYHQGPEWLFVAGYYLQARLRIGDIlggSEKQy--------aIRQVQERLGNAYKHIISSPWRSLPE 1432 Caenorhabditis elegans
Q9W2H8 1522 SNDSTDCTvahganYHQGPEWVWPIGFYLRARLIFAKKcghLDET----------IAETWAILRAHLRELQTSHWRGLPE 1591 fruit fly
Q9HL89  512 PQPERDMA------YHNGTVWPWLAGIFITAAVKTGYD---KHAL----------LEKFAPLFS----------MSRIPE 562  Thermoplasma acidop...
Q973T3  517 DRKSRDEA------YHNGPIWPWLIGAYVDAKLKIESDvikNKLI----------LDVIKPLLE-----YAKKNRGFIPE 575  Sulfurisphaera toko...
Q8TMM8  563 DALTRDTA------YHNGTVWPWLLGAYVKAYLKVNNS---SKSS----------LEEMRVLLEGFDAHLEVAGIGTISE 623  Methanosarcina acet...
Q8XHY8  565 KLFDRDMA------YHQGTTWAFPLGGFFTAYCKVNDY---SKEA----------VDLVDSLMRDMEDHIKDQCLGSIAE 625  Clostridium perfrin...
Q9RXW4  703 PQLLRDAA------YHQGTVWPWPLASYVELLLSRGE------------------LNRARAALAGLTGHVWEAGIGHVSE 758  Deinococcus radiodu...
Q8KPV1  580 DQTQRDAA------YHQGTVWAWLLGSFAIAHYAAFGD-----------------RALAAQVLQPIAHHLQTAGLGTISE 636  Synechococcus elong...
Q8YNC7  601 SPEKRDRA------YHQGTVWTWLIGPFIRSWQRFYPE---QPLP----------FD-WQPLLD---HFLSDACLGSISE 657  Nostoc sp. PCC 7120
P35573 1503 LTNENAQYCPFSCETQAWSIATILE 1527 human
Q06625 1499 LTNKDGEVCNDSSPTQAWSSACLLD 1523 Saccharomyces cerevisiae S288C
O62334 1433 LTNADGEYCMQSCAAQAWSVGCLIE 1457 Caenorhabditis elegans
Q9W2H8 1592 LTNDNGSYCGDSCRTQAWSVAAILE 1616 fruit fly
Q9HL89  563 IFDGSGTGIPKGCIMQAWSHGEIAR 587  Thermoplasma acidophilum
Q973T3  576 LYEDVPPYLPAGCIAQAWSVAEVYR 600  Sulfurisphaera tokodaii
Q8TMM8  624 VFDGDYPHAPGGSIAQAWSVAEILR 648  Methanosarcina acetivorans
Q8XHY8  626 IFDGDNPYKARGCYAQAWSVGEMLR 650  Clostridium perfringens
Q9RXW4  759 VFSGDA-LTPGGCPFQAWSVAELLR 782  Deinococcus radiodurans
Q8KPV1  637 IFDGDAPFLPRGCIAQAWSVGEILR 661  Synechococcus elongatus PCC 7942
Q8YNC7  658 IFDGDPPHRARGAVAQAWSVAEVIR 682  Nostoc sp. PCC 7120
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