2WCD


Conserved Protein Domain Family
HlyE

?
pfam06109: HlyE 
Click on image for an interactive view with Cn3D
Haemolysin E (HlyE)
This family consists of several enterobacterial haemolysin (HlyE) proteins.Hemolysin E (HlyE) is a novel pore-forming toxin of Escherichia coli, Salmonella typhi, and Shigella flexneri. HlyE is unrelated to the well characterized pore-forming E. coli hemolysins of the RTX family, haemolysin A (HlyA), and the enterohaemolysin encoded by the plasmid borne ehxA gene of E. coli 0157. However, it is evident that expression of HlyE in the absence of the RTX toxins is sufficient to give a hemolytic phenotype in E. coli. HlyE is a protein of 34 kDa that is expressed during anaerobic growth of E. coli. Anaerobic expression is controlled by the transcription factor, FNR, such that, upon ingestion and entry into the anaerobic mammalian intestine, HlyE is produced and may then contribute to the colonisation of the host.
Statistics
?
PSSM-Id: 399246
Aligned: 2 rows
Threshold Bit Score: 411.526
Threshold Setting Gi: 229597632
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2WCD_O        10 IvadktvevvKNAIETADGALDLYNKYLDQVIPWQTFDETIKELSRFKQEYSQAASVLVGDIKTLLMDSQDKYFEATQTV 89  Escherichia col...
XP_003425977  32 I---------ERALKSLSNVVVKYKSEFDTRVKFHQLQEAIDAIDEAMLDYQGVAKNKLDQLRTLNSNARNTYQDCVGPV 102 jewel wasp
2WCD_O        90 YEWCGVATQLLAAYILLFDeyNEKKASAQKDIL----IKVLDDGITKLNEAQKsLLVSSQSFNNASGKLlaLDSQL---T 162 Escherichia col...
XP_003425977 103 FEWCVSINSTFNIFIPFIS--DARLTEHDRDIIwnmtINTLRDGEKKTSNSLE-LLVLVQNKTAAVKNL--LDSMLhdiH 177 jewel wasp
2WCD_O       163 NDFSEKSSY------FQSQVDKIRKEAYAGAAAGV-----------VAGPFGLIISYSIA-----AGVVEGKLIPELKNK 220 Escherichia col...
XP_003425977 178 DDFGPQGYYgmqkaaLKNAIAEIQRARKALIIVGIigliftaitafVTGPIGLSLALATAfppaiAAVVKGQRQATYEEQ 257 jewel wasp
2WCD_O       221 LKSVQNFFTTLSNTVKQANKDIDAAKLKLTTEIAAIGEIK--------------TETETTRfyvdyddlmlSLLKEAAKK 286 Escherichia col...
XP_003425977 258 LQTIQAFFNILDDRINKASEIANQINLDLAEDKNNLHELAgllsaadrnkqlllTDSPTVR----------ALLVPSFRN 327 jewel wasp
2WCD_O       287 MINTCNEYQKRHG 299 Escherichia coli K-12
XP_003425977 328 LGNKCHEYAMWHG 340 jewel wasp
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap