3SQ3


Conserved Protein Domain Family
Tyr-DNA_phospho

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pfam06087: Tyr-DNA_phospho 
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Tyrosyl-DNA phosphodiesterase
Covalent intermediates between topoisomerase I and DNA can become dead-end complexes that lead to cell death. Tyrosyl-DNA phosphodiesterase can hydrolyze the bond between topoisomerase I and DNA.
Statistics
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PSSM-Id: 399229
Aligned: 117 rows
Threshold Bit Score: 247.946
Threshold Setting Gi: 124442755
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3SQ3_A          6 KLMKSDFYEREdfmgEVEDMITLKDIFGTETLKRSILFSFQYELDFLLRQF-HqNV---ENITIVG-------------- 67   Saccharomyces...
XP_013946627  133 TVKRTWVRGTA----RRGDEITIEEVFQKDKLELAVLSSFQWDEEWMLSKLdYrR----TKILLLAfardgaqvlefihk 204  Trichoderma a...
EHK17742       80 TVKRTWSRGCA----RTGEEITIEEVFQKDQLELAVLSSFQWDEEWMMSKLdIrR----TKILLLAfakdea------qk 145  Trichoderma v...
XP_014169810  113 VVKKTWIRGQP----RGDDDITIDEVWQKSGLELAVLSSFQWDEEWMMQHVdVrK----TKLLLIAyaaden------qk 178  Grosmannia cl...
EJT68632      188 VVKRTWLRGQP----MTSDDITIDQVLQKDMLQMAVLSSFQWDTDWLWRKVnPmK----TKITLVAyagnev------ek 253  Gaeumannomyce...
EEA18915      220 VVKKTWAFGYS----RNGDDIKIEEVLQTADLELALLSAFQWDMQWMFTKFrTpNK---TRFLMVMqakees------tr 286  Talaromyces m...
EME47312      120 VVKKTWAFGHE----RDGRDIKLEEVLEPSSVRTAVLSAFQWDTEWVLSKLkTpLNggsTKCVFVMqaktpd------er 189  Dothistroma s...
EME85501       54 aVKKTWAFGHE----RTGHDIKLEEVLEPSSVRTAVLSAFQWDIDWLLRKLkTpLNggsTKCVFVMqakeke------dr 123  Pseudocercosp...
CCX07199      543 VVKKTYLKGAA----NGPETITFEDVIQSTTLVTTVLSSFQWDYEWVLKQLpSrRD---HKSLFIIhgktee------er 609  Pyronema omph...
XP_011110827  225 vVKRTFIQGAE----RTSDDITLEEILQKDTLQTAVLSAFTWDFMWILDKLkVgE----CDLVLVVsakede------lv 290  Dactylellina ...
3SQ3_A         68 ----QKGTIMPiearamdatlavilKkVKLIEITMP-PFASHATKLIINFYDNG---ECKIFLPSNNFTSMETNL----- 134  Saccharomyces...
XP_013946627  205 tlmqGNVPA----------------N-IKFCFPPMHgV-GAMHSKLQLLKYPS----HLRVVIPTGNLMPYDWGE----- 257  Trichoderma a...
EHK17742      146 nlmrGNVPS----------------N-IKFCFPPMHgP-GAMHSKLQLLKYPD----RLRVVIPTGNLVPYDWGE----- 198  Trichoderma v...
XP_014169810  179 vemrENVPNSN----------------VRFCFPPMLsV-GAMHSKLQLLKYAD----YLRIVVPTGNLVPYDWGE----- 232  Grosmannia cl...
EJT68632      254 aavvESARGI-----------------ARLCFPPMNgF-GYMHSKLQLLKFPG----FLRIVVPSGNLVSYDWGE----- 306  Gaeumannomyce...
EEA18915      287 lqyqEETANMP--------------N-IRLCFPPMDgQVNCMHSKLMLLFHPE----YLRIVVPSANMVPYDWGE----- 342  Talaromyces m...
EME47312      190 aqyrEWASGFE--------------AcLRICLPPMDgAIYCMHSKLMLLFHPH----KLRVAIPSANLLNFDWGE----- 246  Dothistroma s...
EME85501      124 dqwrEDASDMS--------------HfLRFCFPNMSgLISCMHSKLMLLFHPH----KLRIAIPTANLLNFDWGE----- 180  Pseudocercosp...
CCX07199      610 kaitEVLSFVP--------------L-LKLCFPKLEgQVNVMHSKLMLLFHKDGekeWLRIVVPTGNLTDYDWGD----- 669  Pyronema omph...
XP_011110827  291 dhyrRNLCNIP--------------R-TRLCFPDMSgNINCMHSKLQLLFHLT----YLRVVVPTANLTPYDWGEdisgg 351  Dactylellina ...
3SQ3_A        135 PQQV-------CWCSPLLKI--------GKEGLPVPFKRSLIEYLNSY--HlkdidELITKSVEE-VNFAPLSeLEFVYS 196  Saccharomyces...
XP_013946627  258 --TGvmenmvfLIDLPRLDHpvsthasaARSHAPTRFYTELVYFLQATgvG-----EKMVASLAN-YDFSRTAdLAFVHT 329  Trichoderma a...
EHK17742      199 --TGvmenmvfLIDLPRLGNpa-----tHPPQRPTGFYTELVYFLQSTgvG-----DKMVASLSN-YDFSKTSdIAFVHT 265  Trichoderma v...
XP_014169810  233 --SGtienmvfIIDLPRLPAq------aGRISGKTPFLDDLSYFLKAQavD-----QSLVQSLDN-YDFSATArYAFVHT 298  Grosmannia cl...
EJT68632      307 --TGtmenvvfIIDLPPVGDla-----gSEGNTLTSFGEDLCYFLKAQglE-----ESLIKSLRK-YDFTETSrYGFVHS 373  Gaeumannomyce...
EEA18915      343 -QGGvmentvfLIDLPKKSTn------dAADSPKTAFYEELSYFLKAStlH-----ENIIAKLSA-FDFKETNrYAFVHT 409  Talaromyces m...
EME47312      247 --TGqmensvfMIDLPRLAGst-----sQTTEDLTFFGQELMFFIERQglD-----KDLRKGVLG-FDFSATEhMAFIHT 313  Dothistroma s...
EME85501      181 --TGqmensvfLIDLPRYSDgl-----kASLEDLPSFGRELMYFIQKQglD-----QDVRDGVLK-FDFSATRdMAFVHT 247  Pseudocercosp...
CCX07199      670 -MGGvmenmlfLIDLPKLPS---------INPEQTFFMQELLRFVGAQdvP-----ENILNKIVG-YDFSATEkMAFVHT 733  Pyronema omph...
XP_011110827  352 RSGGvmensvfIIDFPELPKtsi---tgASNPSHTYFSRELLHFCKAKglP-----ADIIKKVDSiYDFTKSEpLAFIYS 423  Dactylellina ...
3SQ3_A        197 TPSKFQSS------GLLSFYNKLEKLSAgtSAsdtakHYLCQTSSIG--TSLS---RARDENLWTHLMIPLFtgimsppa 265  Saccharomyces...
XP_013946627  330 IPGSHSAKnae-------riASVADLGL--ASvd-pvDVDLVCASLG--ALNQ---------QMVRAIYNACrgddgtde 388  Trichoderma a...
EHK17742      266 IPGSHSGNaak-rtGYCGLGASVAALGL--ASpe-pvEVDLVARFFGlsTICGevaNSSTLPSLVGAIYNACrgddgied 341  Trichoderma v...
XP_014169810  299 ISGSHAKDswe-rtGYCGLGRAIKSLGW--ATee-plQLDYLCSSIG--SLGD---------DLLNALYYACqgdtgmke 363  Grosmannia cl...
EJT68632      374 IPGSHMGDswn-qtGYCGLGRAVNKLGL--ATdq-piEVDLVASSIG--SLTS---------KFCSALYKACqgdsgike 438  Gaeumannomyce...
EEA18915      410 IGGSHFGEslt-rtGHCGLGKAVTSLGL--KTre-piNIDFVTSSIG--SLTD---------EFMRSIYLSAqgkqtlys 474  Talaromyces m...
EME47312      314 VGGMNYERtgadrtGLLGLSRAVRYLGL--TTdqrelEIDFAASSIG--QLND---------SQVQDLHSAAsgqdliaq 380  Dothistroma s...
EME85501      248 VGGVHYKDeaa-rtGLLGLSSAVRELGL--STgs-dlEIEFAASSIG--MLNE---------AQVNDLHTAArgkpqq-- 310  Pseudocercosp...
CCX07199      734 IGGSILGEear-ctGYPGLATAVKELGY--NSgk-glEIDFVTSSLG--ALKE---------DFLSALYRAAqgfdgida 798  Pyronema omph...
XP_011110827  424 IGGSHHGEdal-rnGVCGLANAVKNLGL--KTtk-plEVDYVTSSIG--NLNK---------EFLLRIYRALrgdegkks 488  Dactylellina ...
3SQ3_A        266 kdtagrk---------------kaeilptnslineySQRKIK-PYIIFPTEQEFVTSPLKWSSSGWFHFQY---LQKKSY 326  Saccharomyces...
XP_013946627  389 yhkpastssrs-------sakkpttttttatvtsqeQLLRER-FRIYFPTDRTVSQSRGGRNAGGTICVQTkwwRAPNFP 460  Trichoderma a...
EHK17742      342 ykkssgt--------------ssrsraskkpaettsKELKDR-FRIYFPTDKTVARSRGGRNAGGTICVQArwwRSPSFP 406  Trichoderma v...
XP_014169810  364 yeara------------------nkpkkgvlasssePDWKSR-MRVYFPSHQTVVRSRGGIRGAGTICFRRnwwESAKFP 424  Grosmannia cl...
EJT68632      439 heskga----------------kakngmggaasttqAALAQR-FRVYFPSLQSVVASRGGRNSAGTTCLQSrwwNLPSFP 501  Gaeumannomyce...
EEA18915      475 iirtiilnv----------scrlggdgstnaqrttsSEWKSR-FRVYYPSEQTVSQSKGSRRSAGTICFQEkwfTGPKFP 543  Talaromyces m...
EME47312      381 aaeakskaat---------nffakkaasskaastseRDIKQK-LRVYFPTKETVQASTAG--AAGTICLQRkyfEGKTFP 448  Dothistroma s...
EME85501      311 ------------------------------ssstteTSTARKnVRIYFPTADTVRSSTAG--SAGTICLQRkyfEAKNFP 358  Pseudocercosp...
CCX07199      799 kikkpatkgdkks--tmstpepeltsitphepetsfATISSS-FRIYFPSSSTVSSSNGGPNCGGTICFQRsfwNAPTFP 875  Pyronema omph...
XP_011110827  489 vqgipkkysklqqtnpedestaseteeedesddkvwRDLRAS-TRIYFPSRRTVATSKGGLESGGTICFQRkwfTSSSFP 567  Dactylellina ...
3SQ3_A        327 YEMlrNKFkvfykqdpamvtRRRGTTPAHSKF-YMHCatnsagpcdaSQVfkeLEWCLYTSANLSQTAWGTV-------- 397  Saccharomyces...
XP_013946627  461 RELvrDVI-------------SRDRVLMHSKMiFVRRrpgd--sgqaQAVrqsPGWAYVGSANLSESAWGRMskdkstgg 525  Trichoderma a...
EHK17742      407 TELvrDVI-------------TRDRLLIHSKMiFVRRvg------dgQATrqpPGWAYVGSANLSESAWGRLskdksteg 467  Trichoderma v...
XP_014169810  425 RKIlrDYQ------------NVKKGTLAHTKLlFVRR-----------EAssaQAWTYLGSANLSESAWGRLvkdratke 481  Grosmannia cl...
EJT68632      502 RELfrDYM-------------NPRRVLVHSKIiFVRA------------PsggASWAYVGSANLSESAWGKLvkdrtsss 556  Gaeumannomyce...
EEA18915      544 RNTlhDCI------------SRREGLLMHNKMmFVRPekp----inlPGGsncAGWAYVGSANLSESAWGKVvhdrvrke 607  Talaromyces m...
EME47312      449 RAIfrDYK------------STRKGLLSHNKIlCARSk--------------sLAWLYIGSANMSKSAWGEIpkdr--ke 500  Dothistroma s...
EME85501      359 RDIfrDYK------------STRRGLLSHNKIlCARS------------RkekVAWVYVGSANMSKSAWGELgakr--de 412  Pseudocercosp...
CCX07199      876 QGMiyDCK------------SVRPGTLMHNKLlLARPat-------kMKDeeaCAWAYLGSANLSESAWGKLvmdratkq 936  Pyronema omph...
XP_011110827  568 SSLlhDCQ------------STRRGMLMHNKIiFVRFs---------RPKpkaVGWAYIGSANLSESAWGKLvwdrsqkv 626  Dactylellina ...
3SQ3_A        398 -SRKPRNYEAGVLYHSRrlantrkvtc-----------------rtftrdrrgCAGNPTHVAVPFTLPVI 449  Saccharomyces cerevisia...
XP_013946627  526 fKLVCRNWECGVIIPVPesqpvdktt-------------------lptsadddMSMFAGTVPVPMQVPGP 576  Trichoderma atroviride ...
EHK17742      468 iKMSCRNWECGVIIPVPesktvdk-----------------------tvasadMAMFAGTVPVPMQVPGP 514  Trichoderma virens Gv29-8
XP_014169810  482 pRLTCRNWECGVLIPAVprpeaerra------------------nvpregagmLGEFDKSVPVPMVLPGT 533  Grosmannia clavigera kw...
EJT68632      557 pKMTCRNWESGVIVPAGsghelkhqghg--------------raegagicgsvGAVFEGCVPLPMTLPGT 612  Gaeumannomyces tritici ...
EEA18915      608 pKLNCRNWECGVLVPITelppaagsdgeeqnk------dsakkedksgaegdiVEIFGSTVPVPMRVPap 671  Talaromyces marneffei A...
EME47312      501 rRITCRNWECGVLLPVPkeilppackekarrrhtddeedsetdsedeepqlvdMSVFSSLVDLPFEVPGD 570  Dothistroma septosporum...
EME85501      413 nKITCRNWECGVILPVArkvkdengdeet------------ddegedekalvsMNAFANVIDLPFEVPGE 470  Pseudocercospora fijien...
CCX07199      937 pKLNCRNWECGVILPVPksvlgrtlg------------------gedvkrpvgLEAFEKVVPVPMKTPAE 988  Pyronema omphalodes CBS...
XP_011110827  627 fKMSNRNWECGVILPVTlpsgqdhaqe----------------attegkpipdLGVFTNVIPVPMSMPAP 680  Dactylellina haptotyla ...
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