6ENO


Conserved Protein Domain Family
HGD-D

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pfam06050: HGD-D 
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2-hydroxyglutaryl-CoA dehydratase, D-component
Degradation of glutamate via the hydroxyglutarate pathway involves the syn-elimination of water from 2-hydroxyglutaryl-CoA. This anaerobic process is catalyzed by 2-hydroxyglutaryl-CoA dehydratase, an enzyme with two components (A and D) that reversibly associate during reaction cycles. This component contains one non-reducible [4Fe-4S]2+ cluster and a reduced riboflavin 5'-monophosphate.
Statistics
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PSSM-Id: 399208
Aligned: 340 rows
Threshold Bit Score: 39.5842
Threshold Setting Gi: 81452290
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6ENO_A                77 VYVPEEIINATGSACi------------------gL-CGGAQYTVPAGETV--LPRNLCPLIK---SAMG-FKIEricpy 131  Carbox...
sklacau:PSAB_11720    59 vpwampLIYSAGAIPvaf---------------seVgRISGQEAITVSEDYyqMPAETCSMVK---ATAGeWHLRkqa-g 119  Paenib...
CCZ29453             917 WMYHSRLYAAAS-------------------------YVRTVDNLDLIQ----LNSFGCGL-----DAVT---------- 952  Firmic...
agres:bpr_I1470      907 WMYHSRLYAAAS-------------------------FVRTRDDIDLIQ----LNSFGCGL-----DAVT---------- 942  Butyri...
EIM56352             904 WMYHTRLYAAAN-------------------------YVKRRNDLELIQ----LNSFGCGL-----DAVT---------- 939  [Eubac...
WP_014825786         905 WVYHTRLYAAAS-------------------------YVAQQSSLELIQ----LNSFGCGL-----DAVT---------- 940  Desulf...
jgi:Desmer_2594      906 WVYHSREYNAAS-------------------------YVAQQKDLELIQ----LNSFGCGL-----DAVT---------- 941  Desulf...
Q8DVN8               908 WVYHSRLYAAAK-------------------------VVSKNPNLELVQ----LNSFGCGL-----DAVT---------- 943  Strept...
OTooleUCC:LRC_17600  907 WTYHSRLFAAAR-------------------------VAAKIPELEFVQ----LNSFGCGI-----DAIT---------- 942  Lactob...
WP_013421141         107 ggqtvdpFFAAGAIPvvpgplrgwatsmkegltlyQaGQRATDILEAGRSA--ISVDCCNNPVgamEAIR-QNL------ 177  Rhodom...
6ENO_A               132 fQVADYVVGETT--CDGKKKAWEILNEY---IP-VYVMEL----PQkk---eERDRKFWEEEIKDFAQFVEEKTGVKLNA 198  Carbox...
sklacau:PSAB_11720   120 tSITRIFGSSSG--CEPYNLAWEVMKKE---GFdVYTSDVvyraPgvegeryEELVRYFVDEIHDFNEWLTGSR--EIDK 192  Paenib...
CCZ29453             953 --------------TDQVNDILTGSDKI------YTCLKI--------------------DEVNNLGAA-------RIRI 985  Firmic...
agres:bpr_I1470      943 --------------TDQVNDILSGSDKI------YTCLKI--------------------DEVNNLGSA-------RIRV 975  Butyri...
EIM56352             940 --------------TDQVYEILSGSNKI------YTVLKI--------------------DEVNNLGAV-------RIRV 972  [Eubac...
WP_014825786         941 --------------TDQVKEILEAYGKI------YTVIKI--------------------DEINNLGAA-------RIRV 973  Desulf...
jgi:Desmer_2594      942 --------------TDQIKEILEAYGKI------YTVLKI--------------------DEINNLGAA-------RIRL 974  Desulf...
Q8DVN8               944 --------------TDQVEEIMRGHNKL------YTVLKI--------------------DEGSNMGAI-------RIRL 976  Strept...
OTooleUCC:LRC_17600  943 --------------TDQVEEILSRYNRL------YTVLKI--------------------DEGTNIGAI-------RIRI 975  Lactob...
WP_013421141         178 -IPIDMVVPYLAlrCTDIAYTLESYRTLvkdIP-LHFIDY----PVtr--dtEWTVQYVAELLRDLVKRIAQLRGVEVTE 249  Rhodom...
6ENO_A               199 ENLRAGIEKINK--------------------------------KRKALKRLSDLR-KH-NPAPIHGLDVllInqlaFfD 244  Carbox...
sklacau:PSAB_11720   193 ESLHREIVRKNY--------------------------------LMRRMREIMDLRlQH----PFHVKSL--GimylMnG 234  Paenib...
CCZ29453             986 RSLIAALRVKEQkheervvhs---------------tainrpvfTEEMRKE-YTILcPQmS--PFHF------------- 1034 Firmic...
agres:bpr_I1470      976 RSLLAAIRVRKQknkqrtire---------------tanhrvlfTEDMRKN-YTLLcPQmS--PIHF------------- 1024 Butyri...
EIM56352             973 RSLLAAVRVRAKkqqerkiss---------------saedrvvfTEEMKKKGYTILsPQmS--PIHF------------- 1022 [Eubac...
WP_014825786         974 RSLIAAINERDKrqvtpekli---------------trpsrvifTQEMKKT-HTLLvPQmS--PIHF------------- 1022 Desulf...
jgi:Desmer_2594      975 RSLIAAIKERDKrkfipkkls---------------qypkravfTKEMKKT-HTILaPQmS--PIHF------------- 1023 Desulf...
Q8DVN8               977 RSLKAAVKERDQkvkkakldhifnqtpqfpqnleneeskqrpvfTKDMKKT-HTLLmPMlS--PIHQ------------- 1040 Strept...
OTooleUCC:LRC_17600  976 RSLKAAVLERDErhiipekly---------------dlerpkqfTKDMRKK-HTLLmPMlS--PIHQ------------- 1024 Lactob...
WP_013421141         250 EDLWKEIKLENR--------------------------------GRKFARDAVELVwRA-ELPPIRSQNL--SgiitGgR 294  Rhodom...
6ENO_A               245 ------DPERFATKVNELCDELEERVAkGegv--vskDAPRIL-ITGTPQPIPHWKIHALIEGA-G--GVVVGEETcigE 312  Carbox...
sklacau:PSAB_11720   235 lthyfgKPEEYTEVLDALVEELSGlet-------deaERQRAIpLIWTGGSGQEFGIYETIDDAgGslLGFVSSPYtrd- 306  Paenib...
CCZ29453            1035 ---------------D-LMEAAFR--------------------AAGYNLEVLPTDNRHAVDTGlK----YVNNDAcypS 1074 Firmic...
agres:bpr_I1470     1025 ---------------D-ILEPAFA--------------------ACGYNFVVMQNDNRHAIDMGlK----YVNNDAcypS 1064 Butyri...
EIM56352            1023 ---------------N-LIEAAFN--------------------NSGYNMEVLNNDNRTAINAGlR----YVNNDAcypS 1062 [Eubac...
WP_014825786        1023 ---------------Q-FFQTGFE--------------------MAGYTIEILPSVDKSAIDEGlK----YVHNDAcypA 1062 Desulf...
jgi:Desmer_2594     1024 ---------------Q-FFKTAFE--------------------DSGYSIEFLPSVDKSAVDEGlR----YVHNDAcypA 1063 Desulf...
Q8DVN8              1041 ---------------NGLIEEAFK--------------------QSGYNVVILPAMDRKAVDVGlK----FVHNDAcypA 1081 Strept...
OTooleUCC:LRC_17600 1025 ---------------SNLVDVALR--------------------ASGYNVVNLPVERRHSVDEGiK----YVNNDAcypA 1065 Lactob...
WP_013421141         295 fd--rgDSLAGTELLEQDFAEVTQRVRdGvlapgvseDAVRLI-SVGSCFGLQSDFV-----EAhG--GVVVGTDDhlsK 364  Rhodom...
6ENO_A               313 RYFkdlvepaadVEg-mLKNIAaRSLk--vNCACfT-PNTGRLEDILSMVQKLQVDGVIHYSLQFCQPYGVESYLVGREL 388  Carbox...
sklacau:PSAB_11720   307 ----------fpEDidpVESVArFQLqsqmAGASiY-----RRHVIEQQVDRIQARGLILYGYLGCSFGSVTREIYRDYF 371  Paenib...
CCZ29453            1075 LIV----------VgqiMDALLsGKY------------------------DTNKVAVVMSQTGGGCR-ATNYVGFIRRAL 1119 Firmic...
agres:bpr_I1470     1065 LWV----------VgqiMDELHsGKY------------------------DLNRTAVIMSQTGGGCR-ATNYVGFIRRAL 1109 Butyri...
EIM56352            1063 LLV----------VgqlMDAIDsGKY------------------------DPDKIALIMSQTGGGCR-ASNYIAFIRRAL 1107 [Eubac...
WP_014825786        1063 IIV----------VgqiMKALNsGKY------------------------DLNNTSVIISQTGGGCR-ATNYIAFIRKAL 1107 Desulf...
jgi:Desmer_2594     1064 IIV----------VgqlMKALKsGDY------------------------DINNTSVIMTQTGGGCR-ATNYISFIRKAL 1108 Desulf...
Q8DVN8              1082 IIT----------IgqlVEALQsGQY------------------------DLNNTSVMMTQTGGGCR-ATNYIPLLRKAL 1126 Strept...
OTooleUCC:LRC_17600 1066 IIT----------IgqmIEALKsGKY------------------------DLDNVSVMMTQTGGGCR-ATNYIPLIRKAL 1110 Lactob...
WP_013421141         365 IYAdvg----eyGd--pYERMAeSIL-----SYNyEkETEKRAAYVVDLVRRSRANGVVCGYNWGCNYQSAVSRMIADIV 433  Rhodom...
6ENO_A               389 E-RRN----IPFLKLES--------------------------------------------------------------- 400  Carbox...
sklacau:PSAB_11720   372 H-NKG----IPSINLEG--------------------------------------------------------------- 383  Paenib...
CCZ29453            1120 --GKAglshVPVISINMsnslesnpgfklnadlltraaysavfgdifmrcvyrmrpyeltrgsvdavhekwklkcqefvs 1197 Firmic...
agres:bpr_I1470     1110 --KKAgmeqIPVVSLNLsklesnpgfhinfemleraaygavfgdifmrcvyrmrpyek-vegsvnachekwlpvvkefvt 1186 Butyri...
EIM56352            1108 --KKAgypqIPVISLNLvglednpgfkvskdmavravyaaifgdifmkclyrmrpyek-vkgsanrlhekweqicinylk 1184 [Eubac...
WP_014825786        1108 --ADAhlghIPVVALNTgnsssleqnpgfkitlpifkkvmqgliygdllmrvlyrvrpyemepgsanrlyeswvarcqes 1185 Desulf...
jgi:Desmer_2594     1109 --KDAnmehVPVIALNTgnssgletnpgfkftipmfnkimrglvygdllmrvlyrvrpyekfpgsanllydywvkrcqes 1186 Desulf...
Q8DVN8              1127 --KDAgfsqIPVVSISMgnqgteetpgwklnysfvkrllisvlygdlferllyrvrpy-esvkgsantlydkwleiarkn 1203 Strept...
OTooleUCC:LRC_17600 1111 --KDAgfpqVPVISMSLnakgtekspgfkltlplvkrvalaflygdlfervvyrtrpy-eteegavdalhkewldriqpn 1187 Lactob...
WP_013421141         434 KkETG----VPTLNLVV--------------------------------------------------------------- 446  Rhodom...
6ENO_A               401 --------------------DFSE-ED---QGQLKTRIEAFLEM 420  Carboxydothermus hydrogenoformans Z-2901
sklacau:PSAB_11720   384 --------------------TFQVgAP---SGQLLTRIKAFIEM 404  Paenibacillus sabinae T27
CCZ29453            1198 gkhmsffkfqrmcrqmieefDAIP-VS---EDP-KPRVGIVGEI 1236 Firmicutes bacterium CAG:194
agres:bpr_I1470     1187 skhmsfikfqrlcrqiiedfDRIE-IT---DEV-KPRVGVVGEI 1225 Butyrivibrio proteoclasticus B316
EIM56352            1185 qkhvslrkfntlcrsiirdfDRLP-IT---EER-KPRVGIVGEI 1223 [Eubacterium] cellulosolvens 6
WP_014825786        1186 lktgntkdyeknirqivedfDSLP-IH---EDWLKPKVGVVGEI 1225 Desulfosporosinus acidiphilus
jgi:Desmer_2594     1187 lkngnskehaenirqivadfDGLE-LY---EDLVKPKVGVVGEI 1226 Desulfosporosinus meridiei DSM 13257
Q8DVN8              1204 vksgsyfefnrnmkriirefDKLE-TV---NFGQKPRVGVVGEI 1243 Streptococcus mutans
OTooleUCC:LRC_17600 1188 vkngsfhefkrnvakivedfDNIP-L----TAEKKPRVAIVGEI 1226 Lactobacillus ruminis ATCC 27782
WP_013421141         447 --------------------NGLGlSRlqgNEQTQNRIESFIEM 470  Rhodomicrobium vannielii
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