5B86


Conserved Protein Domain Family
Sec6

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pfam06046: Sec6 
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Exocyst complex component Sec6
Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.
Statistics
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PSSM-Id: 399204
Aligned: 33 rows
Threshold Bit Score: 372.822
Threshold Setting Gi: 82077517
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5B86_B           66 QSKVEALYVLLCDQVLGVLRRPLEAAPERLS---QALAVVSQEELEDRRASG-GPLAAAlEA------------------ 123 house mouse
A2AV37          206 FSGVGRLVDALAKELWAVVGSGLSLAHQNPTpfvSAVRIVEREEALDQFFLEeRRSTSGhNIpm---------------- 269 zebrafish
Q0VCR8          188 FEGLGPLAEALGQAVEAAAGAAGQLARENPAllvAAVRVAEVDAGCTTSLEQ---------------------------- 239 cattle
Q8BI71          189 FQGLGLLAEALGQAVEAAAGAAGRLAREDPAllvAAIRVAEVETERTI-LGQ---------------------------- 239 house mouse
Q16I77          179 FEKVETVSATLEKKIRLILQRTLNTVRKEPTvivTALRIIEREEKADAFALQqQKQTGFiPP------------------ 240 yellow fever...
O60645          177 FGSTQGLSDELAKQLWMVLQRSLVTVRRDPTllvSVVRIIEREEKIDRRILDrKKQTGFvPP------------------ 238 human
Q6DJR6          177 FGKVHPLSEELAKQLWMVIQRSIVTVRRDPTllvSVVRIIEREEKVDRRMMDrKKQTGFiPP------------------ 238 tropical cla...
Q6DIA2          181 AMDLCLHYDGMAAEIGAIVREALSSEGVDRDalaELAQVVHLEEEAHQTSQAeGDFL----------------------- 237 house mouse
Q54BP6          183 FSSVPELSHRFENKIWNIVSNSIDIAQIKPAvlvKVAQIIEREKLHEQKQKEkKSQNSLiSSegihddddddddtevnln 262 Dictyosteliu...
jgi:OSTLU_24673  92 FERVDAAWTTFEGVLWNSVRQGILAGESGSVglvRAVRVVAEQEVLDEEFERdALTFEP-ELdaatnk------------ 158 Ostreococcus...
5B86_B          124 -------------------------------TRPRRWLQRWRGVVAEVAAERLDAQPATAPEGrseaesrfLHx----gR 168 house mouse
A2AV37          270 -----------------------------paGRPRNWRDRFFKVMEEAVSARFRSVSYLHTRGpgl--ashLSal---qH 315 zebrafish
Q0VCR8          240 --------------------------------APRDWRQRCLRALQQGLERVHFGTSLQPGPGelakwleaLRv------ 281 cattle
Q8BI71          240 --------------------------------APRDWRQRCLRALQEGLERVHFASPVLPEPGalagwleaLQv------ 281 house mouse
Q16I77          241 -------------------------------GRPKEWRKKALQVLNEAVVQRIEGSKLEERSDnklwlvrdLElt---rQ 286 yellow fever...
O60645          239 -------------------------------GRPKNWKEKMFTILERTVTTRIEGTQADTRESdkmwlvrhLEii---rK 284 human
Q6DJR6          239 -------------------------------GRPKKWKDKMFDVLDKTIITRIEGSQADTRESdkmwlvrhLEii---rR 284 tropical cla...
Q6DIA2          238 -------------------------------STPRHWRMHWEDAVRLSAQESVQQAGAKVIPGaaegssdlAQllaelgG 286 house mouse
Q54BP6          263 nsnkqqnnenensssnnnnnydinnedegydRNRSNYGDRFLEVLIQSISGKFEPMFLNSHNDl-------VQtlk-dvN 334 Dictyosteliu...
jgi:OSTLU_24673 159 -------------------------vinvapPEPKRWKTKVLEQMSIAVEARLALIAEGFSGLddk--esiEHvvg-alD 210 Ostreococcus...
5B86_B          169 TXKEDLEVVVERLKPLFPD-EFNVVRTYAE-SYHYHFASHL---------------CALAQFE--LCERDTYLLLLWVQn 229 house mouse
A2AV37          316 CIMGDLSTVRHCLEQCVPA-HYHLTRAYLH-FCHQFLQTHL----------------GLVSGWe-LEGGEIFAVLNWVLh 376 zebrafish
Q0VCR8          282 aLPAELAMAEALVAPCCPP-HYKVVQLWAH-TLHGGLRRCL---------------QQLLEGPe-LEEADTFTLLHWVLh 343 cattle
Q8BI71          282 aLPAELATAEALVAPCCPP-SYRVVELWAH-TLHSGLRRSV---------------QQLLAGPe-LGAADTFALLHWALh 343 house mouse
Q16I77          287 FLLEDLRVVKSLCVPCFPP-HYNILKEYVS-MYHNALSKYL---------------EELIQMG--LEGNEFVTILSWIMn 347 yellow fever...
O60645          285 YVLDDLIVAKNLMVQCFPP-HYEIFKNLLN-MYHQALSTRM---------------QDLASED--LEANEIVSLLTWVLn 345 human
Q6DJR6          285 YMLEDLIIIKNLMVQCFPP-SYNIFNRVLD-LYHQALSSRI---------------QELASEE--LEANEIVSLLTWVLn 345 tropical cla...
Q6DIA2          287 VVRHDLQKVRLEMQPAYEAtDFPVWETYLR-AFHSAVAQRL---------------QELARDArgCE--QLYVLLDWAAn 348 house mouse
Q54BP6          335 KMVDELFIVMDIVQECYPP-SYDLFNFYVD-QYHTKFYSLFgsfsnlmesshvnnnYQVVVTKn-IPSAHILMLVEWVVk 411 Dictyosteliu...
jgi:OSTLU_24673 211 ESLVSLAETFDYTIPAFPP-EWRVFETVVApTYHAGVCDLL---------------ARLSSSPn-TSNGDMVATVKWGQ- 272 Ostreococcus...
5B86_B          230 LYPN-DILnspklaQEL----------QGVgLGSLLPPKQ-IRLLEAXFLSNEVTSVKQLXARALELESQRWTQDVAP-- 295 house mouse
A2AV37          377 IYNSsEMMgepallAELe---------IEN-LGPLISQEG-LEQLQNKYVQKVRKSVSEWMQKALEVELTDWQRDQEPd- 444 zebrafish
Q0VCR8          344 VYQGpEMMgslelgPEAd---------VSD-LEPLLTLEN-IEQLEATFVAKVQAKVAQWLQKALDGEVVEWGREQEPd- 411 cattle
Q8BI71          344 VYTGkEMMgnlelgPEAd---------VSQ-LEPLLTSEN-IEQLEAAFVAQVQVSVAQWLKKALDGEVAEWSGEQEPp- 411 house mouse
Q16I77          348 TYPGrELMqhpdlmID-----------LSD-VGPLVGNEV-LKEMETAYLQTMERNYQEWMTKTLETEKADWINGVPAd- 413 yellow fever...
O60645          346 TYTStEMMrnvelaPEVd---------VGT-LEPLLSPHV-VSELLDTYMSTLTSNIIAWLRKALETDKKDWVKETEPe- 413 human
Q6DJR6          346 TYQSvEMMgnpeliPEIn---------VKS-LKPLLSQDI-VDQLLHKYMATLRSNIIAWLRKALETDKKDWDKNTEPe- 413 tropical cla...
Q6DIA2          349 VYGSpDFLgapdlaL------------PTEpLPPLLEPAL-WARLESDYTSFLETKITSCFDSILQLEQNRWEADEDR-- 413 house mouse
Q54BP6          412 NYSRdLSRl-----------------gIQD-ISPPLLDS--LDPLIKIYKMHIKQLMREWCDNIINNDNQNKp------- 464 Dictyosteliu...
jgi:OSTLU_24673 273 HYFNaMQSlgldieITDdahacsveyaDESnESPPLPYPVgLSTVIETYCDRLRVTISGWTNNLCRVA------KSRPpk 346 Ostreococcus...
5B86_B          296 QSLDGHCHSELAIDILQIISQGQTKAeniTSDVGXQIKQLLLVELAALLRSYQRAFDEFLEKSKLLRN------------ 363 house mouse
A2AV37          445 IDHEGYYHTSLPTIITQMLEENARVAlmiSEALRDQTIQMGLYEMEKLLSRFRDAVIEFGKEHRKDPTvn---------- 514 zebrafish
Q0VCR8          412 TDLSGFYHSPLPAIVLQILEENIRVTrivSVSLEQRVHGMALSELSAFLRSFTDALIRFSRDHLRGEAvv---------- 481 cattle
Q8BI71          412 TDPSGFYHSPMPAIVLQILAENIQVTnliSDSLHRRAHNMAVSELGAFLRSFSDALIRFSRDHLRGDAva---------- 481 house mouse
Q16I77          414 SADQ-YYHTSAPVIIFQMIDQNLQVTntiHSDLTFNALILSIQQVIKYGHNYRGAIIEYKERHFRDRSqa---------- 482 yellow fever...
O60645          414 ADQDGYYQTTLPAIVFQMFEQNLQVAaqiSEDLKTKVLVLCLQQMNSFLSRYKDEAQLYKEEHLRNRQhp---------- 483 human
Q6DJR6          414 ADQDGYFQTTLPAIVFQMFEQNLQVAaqiSDDLKKKVLHLCLQQMNTFLNRYAEEAQLYKEDHLRSRQhp---------- 483 tropical cla...
Q6DIA2          414 EVLQGLYHAPLSIDVHMLVAEHVKAAgaiSAELEATTLQICARALCLFVPRFEKAFLASKAV------------------ 475 house mouse
Q54BP6          465 EVVDGQYCSLAPIQLFESVASQLDIA---AATKCQKLVVGVMEEVVSALMYFQVQSITLLQERNHEI------------- 528 Dictyosteliu...
jgi:OSTLU_24673 347 EDGSGKLWNPSDLDFFRLIADQMMIA---IETQSNVFVRQCGRVAAEMITNYASAVADRLGMPSETLSgvpcrtpsrggh 423 Ostreococcus...
5B86_B          364 ----------YRVNIXANINNCLFFWT---SVEQKW--------QISHDSLNRLLEPLKDLKAHGFDTLLQSLFLD--LK 420 house mouse
A2AV37          515 --------kfYLHYLLACINNCIILKTsteSLQQQIcsfv---snrySRIPLGPLAALDRAVRKACRLVMDHLLFE--LQ 581 zebrafish
Q0VCR8          482 --------phYVPYLLATLNHQLALSSsvsVLQPKWv---------vPGVLAPVEAELDKLQKRICRLVLEALLAE--LQ 542 cattle
Q8BI71          482 --------phYVPYLLSAFNHQSALRSsvsVLLPDGe---------aSGVLAPVEAALDDVQRRICRLVLEVLQVE--LQ 542 house mouse
Q16I77          483 --------pfFTQHIITIVNNCAQMKElaqQMKQLYwpks---ktmhYEEFERLLNTYQLLRDEAGLFLLEEAFLD--LE 549 yellow fever...
O60645          484 --------hcYVQYMIAIINNCQTFKEsivSLKRKYlkn--eveEGVSPSQPSMDGILDAIAKEGCSGLLEEVFLD--LE 551 human
Q6DJR6          484 --------acYVQYMIAIINNCQTFKEsivSLKRKYlrde---ddiiGFGSSAMDTTLDSIANDGCCSLLDEVFMD--LE 550 tropical cla...
Q6DIA2          476 ----------SEWYLGAYINACVELRT---SLLARF-----------PGTIKELEKPLVAATNSFQKHLLQIVQQD--MQ 529 house mouse
Q54BP6          529 ----------KLENVIAYVNNNSKCYDhtqTIVDKVsnild-sehmGYLDFDPVLEGFLNVSKVATQAISSVIFRD--LD 595 Dictyosteliu...
jgi:OSTLU_24673 424 dsaardaqpvSFETIVAGVNDTRRCRSlaaQTQKTIldalgmkddVMVREFDHAMHVFNRVHAEARRMISRQVLDDpgLV 503 Ostreococcus...
5B86_B          421 PLFKKFTQ----TRWANPvETLEEIITTVSSSL-PEFSE-LQDCFREELXETVHLHLVKEYIIRLCKRRLVLktaEQQQQ 494 house mouse
A2AV37          582 PHLQELLS----STWLDQgDVTLNMCGVLERHC-ELYNR-VRQPCRQRLKEECQWLTVVEYVRAVMQKRLVCrssDEQKQ 655 zebrafish
Q0VCR8          543 PLFAALPS----RRWLSSpELLDDVCKRTARFC-QNFQH-VRNPAVQLLLVEAERTVVLQYLSALMQGRLVCrgaDERTQ 616 cattle
Q8BI71          543 PLFSALPS----RRWLLSsELLDGVCEQTSHFC-QDFWR-VRKPGVQLLLAEAERTVVLQYLRALMQGRLVCrgtDERSQ 616 house mouse
Q16I77          550 IHFNELFT----LKWVGTtVSVDTICVTLEDYF-QDYNH-LRSVNFEYVINEAQRLVAKRYIKAMLSKRLSkp-rQECEL 622 yellow fever...
O60645          552 QHLNELMT----KKWLLGsNAVDIICVTVEDYF-NDFAK-IKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFrspEERKE 625 human
Q6DJR6          551 QHLNDLMT----RKWLGGsNTVDTICVTIEDYF-NDFAK-IKTHYNQEMTIKAHRKVVTEYIKAIMQKRISFrnaEERKE 624 tropical cla...
Q6DIA2          530 PLFKVLYT----KSWLTQ-DTLRPLMDKVVDFA-HHLEH-VTPPLAQETLQEVHRFVVREYLGQVLRPHERFsgqDRL-K 601 house mouse
Q54BP6          596 ECIHKFYT----VEWYQE-DLMQPIINTFEDYVtNDIQKyILENYLKRLALLLLDTLIEQLLAQLIGGKNKF-----NEN 665 Dictyosteliu...
jgi:OSTLU_24673 504 EVMNTFYGskvdGPWATG-ESMTTLLATVEDYL-GDTEDwLTAEVAGSVTETLFEYLIELLFILFTKQASVV-----APH 576 Ostreococcus...
5B86_B          495 LARHILANADAIQGFCTENGS----TATWLHRALPXIA------EIIRLQDsSAIKIEVATYATWYPDFSKGHLNAILAI 564 house mouse
A2AV37          656 LAQRMTQDAQQLRDHLQSMEIdgtiGEVNPTALIAALA------DIINLKDpGMLLLEISGLLSKYPDISEEHVSVLLDI 729 zebrafish
Q0VCR8          617 AAERMQHDAAQLQELFLGLGLe---ESVQCVPVLLALK------ELLNLRDpTLLGLVVAGLRQQFPDVSEDHVSALLDL 687 cattle
Q8BI71          617 AAERLRQDAAQLKELFLGLGLe---ESAHCAPVLLALR------ELLNLHDpTLLGLEVAGLRQQFPDVSEDHVSALLDL 687 house mouse
Q16I77          623 MAKKVIKETKQIKMFFEKVAPnv-aKNDSPIDVISNLA------NLL-TCDaEMLILDLHTLLSSYPSLTEDHVVRLFYM 694 yellow fever...
O60645          626 GAEKMVREAEQLRFLFRKLASgfgeDVDGYCDTIVAVA------EVIKLTDpSLLYLEVSTLVSKYPDIRDDHIGALLAV 699 human
Q6DJR6          625 GAEKMIKEAEQFKFLFKRLTAgfieDTDGLCNTIIDIA------EVLKLTDpSLLYLEVSTLVGRYPDLRDDHIAALLAV 698 tropical cla...
Q6DIA2          602 GSNKMNLDAQAISNTFQGLGS----EAKWLDQAILSVA------EILGETYkDDIRRHLETLIRSYPDIRRDHILAILAL 671 house mouse
Q54BP6          666 TYKILSNDCDKLLDFFKKYLR-----LSVVTAKVQILEdf---kQMITSSI-DMVPVYFRSVINFHKDINERVVELVLYQ 736 Dictyosteliu...
jgi:OSTLU_24673 577 TAARLEADERALTQSMSVRMS--------TNKAIGRIArlqnlrGLVCAASpDAFVHEYGVLLGNWPDAGLDCVAAVLSA 648 Ostreococcus...
5B86_B          565 KGNLPSSEVRSIRNILDINTGVQEPPr---------PLFSLI 597 house mouse
A2AV37          730 RGDVPKEVRKSVLDFLDQSAPPLPPGy--------rPIFTEI 763 zebrafish
Q0VCR8          688 RGDVSREQRLAALSSLRAGPQPSPQAgr-------rALFSLV 722 cattle
Q8BI71          688 RGDVSREHRQAALSSLQAGPPPSPSTgr-------rALFSLV 722 house mouse
Q16I77          695 RNDFKASEVKEKVHDAIVSKKVTVSHdk------qdSIFKEI 730 yellow fever mosquito
O60645          700 RGDASRDMKQTIMETLEQGPAQASPSy--------vPLFKDi 733 human
Q6DJR6          699 RGDASREMKQTIIETVEQSQRQQSANy--------tPIFKDI 732 tropical clawed frog
Q6DIA2          672 R-RLGRRRNQNLLQHTQDLLRAAHETrlp----shhVLFEEI 708 house mouse
Q54BP6          737 RTDISKSEITEVLGQIKTIVETVHTDptn----pptGIFSRM 774 Dictyostelium discoideum
jgi:OSTLU_24673 649 RGDFDKATSRATLERCRDVCITKLAAiagerpsvgvSAATSV 690 Ostreococcus lucimarinus CCE9901
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