4ESJ


Conserved Protein Domain Family
DpnI

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pfam06044: DpnI 
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Dam-replacing family
Dam-replacing protein (DRP) is an restriction endonuclease that is flanked by pseudo-transposable small repeat elements. The replacement of Dam-methylase by DRP allows phase variation through slippage-like mechanisms in several pathogenic isolates of Neisseria meningitidis.
Statistics
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PSSM-Id: 428737
Aligned: 13 rows
Threshold Bit Score: 263.824
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ESJ_A           4 MELHFNLELVETYKSNSQKARILTEDWVYRQSYCPNCGNNPLNHFENNRPVADFYCNHCS----------EEFELKSKKG 73  Streptococcus...
CCY70505         1 MNLQMDRRKAENYSSNAQKIRVMTENWVDKNMFCPYCGNPYVSHFENNRPVADFFCPSCM----------EEYELKSKGT 70 
CDC02967         1 MNYNFNLSLIENYKSNSQKIRVMSETWLAENVYCPYCGNSHLSKFANNKPVADFYCDSCG----------EVFELKAKEN 70 
WP_013217935     1 MELNFDPSIAASYHSPTQKARVLTEGWVAGQSYCPNCGHRQLNQFEAGRRVADFFCSVCG----------EEFELKSKKS 70  Dehalogenimon...
CCY65281         1 MNLFFDNKICLKYKSASQVARIVTEYWLAQNMFCPICGAPLLHQYTANKPVADFYCDLCK----------SDFELKSYKS 70 
Q5FAK4           1 MNLFFDTQLGKQQNKATHKIRVMSEAWLEKNGYCPCCGSKPMQRFANNKPVADLFCPNCH----------EQYELKSKNQ 70  Neisseria gon...
EQB65564        13 L---------REYKSPSQIARNVTEKWAKDNLYCPKCGSQ-LKQHRNNTEVYDFFCDHSNqefilfptqlEEFQLKSTKS 82 
BAJ62798         9 LHL------TTQYTSASQRARVLTEVWVAENFLCLTCDRK-ISALPANTRACDFQCESCN----------ERYQLKSSSK 71 
WP_003660724     1 MNLYFDKNLANEYSSKAQIARVLTENWVLNNSYCPKCGNLPLSEFENNRPVADFYCQNCL----------EEFELKSKNG 70  Moraxella
jgi:Calni_0428   3 MNINLNTNIAANYRSNTQKIRVITEYWVKQNGYCPNCGNKLLS-FANNRPVSDFFCDNCK----------EEFELKSKKG 71 
jgi:Sdel_1531    1 MNLHFNRSLIQEYKNSSQIARVLTENWVEKNIFCPSCGTP-IQSYENNRPVADFYCLTCK----------EQFELKSKKG 69 
jgi:Amuc_1564    1 MDLFFNNNVTEGYKNHSQIARRLTEDWVERNMFCPICGHSVLNHYQNNKPVADFYCCCCH----------SDFELKSLKS 70 
Q73N87           1 MIYRFDISLIKKYHSKSQIVRVLTEDWVLRNFNCPICGKLKIEAYPNNYPAGDFFCKNCK----------SDFELKSKES 70  Treponema den...
4ESJ_A          74 ----NFSSTINDGAYATMMKRVQADNNPNFFFLTYTk-NFEVNNFLVLPKQFVTPKSIIQRKPLAPTANRAGWIGCNIDL 148 Streptococcus...
CCY70505        71 ----SISNKVNDGAYNTMIERITSVNNPNFFFMHYNktNLQIENFVMVPKYFFSPDIIEKRKPLSDTARRAGWTGCNILL 146
CDC02967        71 ----NIGKKITDGAYSTMIERITSISNPDLFVMQYTk-EYQVLNLLVVPKFFFTPEIIEKRKPLSENARRAGWIGCNILI 145
WP_013217935    71 ----VLTGRVVDGAFSAMMERLTSRTNPNLFLMNYDaiSHSVTDFLVVPKHFFTPTIIEKRKALSPTARRAGWVGCNILI 146 Dehalogenimon...
CCY65281        71 ne-gKIKHKITDGAFRTMIERITSLKNPHLFVMSYA--NMEINNLLLIPKFFFTPNIIEKRPPLKETARRAGWIGCNIEI 147
Q5FAK4          71 k---TIGNSVPDGAYRTMLERIRSDTNPNFFFLAYKkaDYSIRQLVLVPKHFITPDMIIPRN--KGIKNRPHHIMCSINL 145 Neisseria gon...
EQB65564        83 fpynGFPKKIVGSGYDAAQRRLDSGMFPSLILLHYQrkAEEVRDGLLIHRLSIPPSSIRPRKPLSNNARREGWRGYEIIM 162
BAJ62798        72 ----NLSNRILGAEYHTTLTTVRLDRHPSLILLQYNrdNFSVANLKILHGSWITENVVIPRSPLRPPARRAGWQGCIIDL 147
WP_003660724    71 ----RLPNVITDGAYATMIERINANNSPNFFFLTYDk-QWRVNDFLIIPKQFFTPSIIIKRKPLSPNARRAGWVGCNIDI 145 Moraxella
jgi:Calni_0428  72 a---EIGMKIVDGAYSSMLNRITSERNPHFFFLTYDktKMTVVNFFIIPNFYFTPEIIEKRNPLTPTAKRSGWIGCNINL 148
jgi:Sdel_1531   70 ----SLGKKVTDGAYDTMIARLKSSENPNFFFLTYElkTLQIHNFVVMPKHFFTPEIIEKRKPLSPNAKRAGWVGCNILL 145
jgi:Amuc_1564   71 sn-kILSKKINDGAYDTMISRIKSYNNPNFFFMNYA--DGAVNNLWLIPNHFFIPAIIEKRPPLSANAKRAGWTGCNILL 147
Q73N87          71 is-gKLPNIITDGAYKTMIERITSYRNPNFLFLTYK--DYEVSNFILIPNHFFTPSIILKRKPLSNTARRAGWIGCNIDI 147 Treponema den...
4ESJ_A         149 SQVPSKGRIFLVQDGQVRDPEKVTKEFKQGLFLRKS 184 Streptococcus pneumoniae TIGR4
CCY70505       147 GRIPEEGRIYIVQNEKEVSIEKIIEKVHKTEFLRGS 182
CDC02967       146 SDIPKQGKILIVDRQHLRNKEDVINDYKLIKNMQTN 181
WP_013217935   147 DDIPRPGRIYLVRNRNIEPLSDVMATWQKTLFLREE 182 Dehalogenimonas lykanthroporepellens
CCY65281       148 GNIPEIGKIYIIKNKEEINKADVIKQYQQVLNLQTS 183
Q5FAK4         146 APLPESGKIFLIDDSRIIEPETVLKKWQSNLFLRNQ 181 Neisseria gonorrhoeae FA 1090
EQB65564       163 QRIPYMGRIPFIEEGKVTEKETVLAKWKYVENIMEG 198
BAJ62798       148 RSIPASAFVEIIKDGQILPQVVIKNHWQTARAISSF 183
WP_003660724   146 SNVVDFGKIFLVKNSQIINQNLVQEHFNNTLFIRTK 181 Moraxella
jgi:Calni_0428 149 SLIPEMGKVFYVKNSITFSKYEVLHDWEKTQFLKTE 184
jgi:Sdel_1531  146 SALPESGKIFYIHNQTIQSKDAILEKWAKTLFLKES 181
jgi:Amuc_1564  148 SEIPESGKIQIIKNSIVIEKEEILAKYKRTKSLLTK 183
Q73N87         148 SKIPDAGKIFIIKDQIETDSKEIINKYAKIKSLKKT 183 Treponema denticola
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