Conserved Protein Domain Family
Myosin_TH1

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pfam06017: Myosin_TH1 
Unconventional myosin tail, actin- and lipid-binding
Unconventional myosins, ie those that are not found in muscle, have the common, classical-type head domain, sometimes a neck with the IQ calmodulin-binding motifs, and then non-standard tails. These tails determine the subcellular localization of the unconventional myosins and also help determine their individual functions. The family carries several different unconventional myosins, eg. Myo1f is expressed mainly in immune cells as well as in the inner ear where it can be associated with deafness, Myo1d has a lipid-binding module in their tail and is implicated in endosome vesicle recycling in epithelial cells. Myo1a, b, c and g from various eukaryotes are also found in this family.
Statistics
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PSSM-Id: 399188
Aligned: 179 rows
Threshold Bit Score: 116.155
Threshold Setting Gi: 307212631
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AAWC:PGTG_00428.3  769 RDAGHQALGGRKERRRFSLLg-sRKFLGDYLNV-GGfdgktkksALGEMLYSKLGLS--ASERVIFSSKahilVSKLGR- 843  Pucc...
XP_004347365           837 KLWASETFKGRKESYPQSVP---TKFLEDTVGLqQE--------AYSRKWTKFAGANn--NPAVVYASS----GFKVDRa 899  Caps...
Q8T6L6                1062 KVTASIIFKDRKASYGRSVG---HPFVGDYVRLrHN-----------QQWKKICAET--NDQYVVFADI----INKIARs 1121 frui...
XP_011456205           881 KLMASELFKDKKEGYAKTVP---IPFKGDYQNLlAN-----------PKWKKLQSQMp-QDSHIVFADV----VQKIHRa 941  Paci...
EGD76729               867 KLVASRLFKGRKASYPISVG---QPFVGDHVGLhVG--------EVAPKWRKVAEQTk--SSEVLFAQR----VEKINRt 929  Salp...
EFC50728              1400 QSIGSDLYKGRKARKKASMM---REYMGDYLPNhYN-----------KLVQQLLQKN--GDTQVLFASE----VLKINK- 1458 Naeg...
EFC44202               743 KREINNIFNNQKKRRRISYN---RIYQGDYLNFaFN-----------SEMAKLLAKH--NDSMIHYSGR----IQKINN- 801  Naeg...
EFA79585               789 KNYSQNLFQGKKERNRDSLVlssLAFIGDFLSVaND-----------DYTKQVLAREegPNASVRLSVS----VSKINR- 852  Hete...
XP_002683472          1188 tNVVQDIYQGQKLRRKDSLL---KWYLGDYLHVaST-----------KQFEKIKKEF--GDSQLLYSGL----VQKINK- 1246 Naeg...
XP_002123096           878 KLHASNLFKGKKSLYPSSLV---QKFVGDHVTLsSN-----------QKWRKVGGGA-----IIIFADE----GFKIHRn 934  vase...
WGS:AAWC:PGTG_00428.3  844 SSKLSPRFLILTDRAVYILIT-Ql-VAGtdgqkrSETVVERKINVSVINSVGVSHLRDDWIVLNVS---N----SEEQ-D 913  Pucc...
XP_004347365           900 NGVARPVIFLITTSSIYVIGD-KafD------------SRYHVLFADIKGVSTSKLGDNTVILHIAedkAdk-nRKKG-D 964  Caps...
Q8T6L6                1122 SGKFVPILLVLSTSSLLLLDQ-RtlQ------------IKYRVPASEIYRMSLSPYLDDIAVFHVKaseFg---RKKG-D 1184 frui...
XP_011456205           942 NGKAVEQLLVMSSQNLVLVEH-HsmM------------VKYRIPITDISAMSVSPHPDKIIVFHVQkheNgdgsCKKG-D 1007 Paci...
EGD76729               930 NGHVVDRVLILCPTQLLILDE-Km-K------------LKYCVDLADVEQLSATTQSDTLVVIHVApdrEkk-sTAKG-D 993  Salp...
EFC50728              1459 NLKTQKRIMIITDKHIYNIDP-QefK------------VKRIIDLDEIEGASMSPFADDNFCLHVPs----------SyD 1515 Naeg...
EFC44202               802 RNKIQDRTLVITESNIYNIDW-NdkKN--------KMKLKRILPLSDLISLKVSPFTDGYFVLFFGt----------RyC 862  Naeg...
EFA79585               853 HQKIQKRALIVTNSNILHISThKpkKDG------SWFVVKRKIAFSALEKVSLSHLCDNFFVLHVPs----------EtD 916  Hete...
XP_002683472          1247 RYLVQDRKLLVTDQAVYNLD--NdlK------------VLRRIPFKEIAGISVSTMRDGFFILKVPg----------EyD 1302 Naeg...
XP_002123096           935 NGKFVSCYIVMTDNAVLLLEE-KslK------------QKCRVAVHDISGVSFSPYQDGMMILHCKppaEs--kKHKG-D 998  vase...
WGS:AAWC:PGTG_00428.3  914 PLLSCVFKTELITRL-----KQLQS-SLTVNIGPTISYRKKKDK-------MAVIKFQ-KDEt---IQR-------GDVY 969  Pucc...
XP_004347365           965 IVLVVNNAIETIARLff--afKAQNqALQVSISEPINTTFGGRPhsisfaySAAPELT-Eiq-------------fKKTK 1028 Caps...
Q8T6L6                1185 FVFQTGHVIEIVTKMflviqNATGK-PPEIHISTEFEANFGQQTv------IFSFKYGgMSDla-qGPpk-----vTRKA 1251 frui...
XP_011456205          1008 FVFVCEHTIELVSKAclvikNIKDT-LPEIHIAPLLKAQFGKSE----------VQLSfKNGltenLPggv---kvVRKK 1073 Paci...
EGD76729               994 HMFYCRSLIEFATRLdiayrKHCNAkRLKMTISDSFEIQIDKRGt-------tTVNIE-RGEa---DAQqt---riQKSK 1059 Salp...
EFC50728              1516 YLYDSDKKSEIMDVLsnaimKKSQK-KLPINIADTFSFSPGGND-------VVNINFV-E-------DSnanetfiEPHN 1579 Naeg...
EFC44202               863 YFFNSDDTSEIVSILirifkQKQKK--IPVEVAQQFDYKPTLKE-------TRTLKFI--EV----SAIpkngpidKTGK 927  Naeg...
EFA79585               917 YICETNRKTVFITLLsklyeKQQSK-PLNIEFSDSIAYRTQKGN--------TEAKFTkV-------DQlpkeqlyTAKA 980  Hete...
XP_002683472          1303 YIFSSSSKTEIIKAImdakkKVENK-SLELQVDDKLVYTVHKGKg------VKTLDFQdD--------LtvkstliFPTS 1367 Naeg...
XP_002123096           999 LILNVAHSIELATKMsll-veKSTNqKLSCIIEQK--VDLKCKSp-------mSLQFN-EPSa---RVVggptvkkNKHM 1064 vase...
WGS:AAWC:PGTG_00428.3  970 KSHTVSV 976  Puccinia graminis f. sp. tritici CRL 75-36-700-3
XP_004347365          1029 NQFNASI 1035 Capsaspora owczarzaki ATCC 30864
Q8T6L6                1252 NRMEIIV 1258 fruit fly
XP_011456205          1074 HTMDILY 1080 Pacific oyster
EGD76729              1060 HALRLFI 1066 Salpingoeca rosetta
EFC50728              1580 NNLVVRV 1586 Naegleria gruberi
EFC44202               928 SEITVSI 934  Naegleria gruberi
EFA79585               981 ERGNIKI 987  Heterostelium album PN500
XP_002683472          1368 TGALIRV 1374 Naegleria gruberi strain NEG-M
XP_002123096          1065 FIVGLPV 1071 vase tunicate
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