Conserved Protein Domain Family
TRP

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pfam06011: TRP 
Transient receptor potential (TRP) ion channel
This family of proteins are transient receptor potential (TRP) ion channels. They are essential for cellular viability and are involved in cell growth and cell wall synthesis. The genes for these proteins are homologous to polycystic kidney disease related ion channel genes.
Statistics
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PSSM-Id: 428720
Aligned: 193 rows
Threshold Bit Score: 150.368
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EME48537      199 VGSVLGIFTFVALIAsfaTAIY-GEAvPT---------MRLHYAHSlsVGVVFAVWQHIFFTGALSVNWPSVLVAWWTNF 268 
EMT61990      174 VTYLSVGVVGAALLVsgaSAASsALS-GTagagh-------ggapSpsFAETLGWFQGMAMNGMLSVDYPPVYRSFAKNF 245 
EJP64554      173 VSYVAAGVAGVALLAsgiSAAGaALG-SGa-------gGPGTGTVSpsFTETFGWFQGMAMNGMLSVSYPPVYQSFTKNF 244 
XP_006674730  170 VSYVAVGIAGVALLGsgvSAVGaALG-GGt-------sG-GAGTVSpsFSEVVGWFQGMAMNGMLSVQYPPIYESFTKNF 240 
EFY90929      173 ISYVAAGVAGAALIMsgvSAVGaALS-GGsaal-gsgsGGAMGSISpsFGETIGWFQGMAMNSMLSVDYPPIYRNFAKNF 250 
CCE30584      177 VSYIAAGIAGAALVMtgiSALGaALS-GGtasl--ggsGMATAAVSpsFSETMGWFQGMAMNSMLSVQYPQIYRSFAKNF 253 
XP_014175070  177 VSYAAAGLTGAALLIsgvSAVGaAMA-GGsgaaggsaaAGGIGTLSpgFTEVFGLFQGMAMNGMLSVNYPQVYRSFSKNF 255 
XP_007789141  169 ISYIVAGIAGAAFVAtgaSALGaAVS-GAssta-----gggaGTISpsFSEMVGVFQGFAVNGMMSVNHPPVYRSFAKNF 242 
EPS31243      165 VSWASAGIAAGALALggiSAL------GTa-------gASGVPASSpsVGDIMGWFGSVAMNGMLSVHYPPVYKSFTKNF 231 
XP_002564816  167 VKYVSAGIAAGALALsgvSAV------GSa-------gAAGSTTSSpgFGDVMGWFHSMATNGMLSVAYPQVYRSFSSNF 233 
EME48537      269 AWAGGMIYTSSMQRSIDSLIGTNIGnts--------qvgAAQS---GADNSNvgGGydisliykRMMgsgierafsaasr 337 
EMT61990      246 GFSAGIIPWESLQKSIDNFRNMTGGdltnds---fevlrNATLvfsDNSTS---SPedhsykvkRAFntfes-------- 311 
EJP64554      245 GFSVGLVPWTGALSAIDSLRESTGGnltydn---aeyvaNAT------------AGqgsmfhakRALgai---------- 299 
XP_006674730  241 AFSVGLVPWSGMLTSIDKFRESTGGnltndn---aayiaNAT------------AGqggalhlkRAVgaa---------- 295 
EFY90929      251 AFSVGIFPWSGMQSTIDNFRSKTGGnltqds---fsylqNATLvfpDGSTSS---PnkglfnfkRAIddf---------- 314 
CCE30584      254 AFSAAVIPWSGMQSAIDGFRSHTGGdldqds---yayleKATLvfpDGTTRS---PnqglfkfkRAVdaf---------- 317 
XP_014175070  256 AFSTGLVPWTQLQTSIDNFRAATGGnltdns---vaylrNKTLvysEGSSSta----------kRAVhar---------- 312 
XP_007789141  243 GFSTGLFPWRSMQVSIDGFREATGGnltqds---vqfleKTTLvfsDGSTA---APagssanskRALagf---------- 306 
EPS31243      232 AWSTGLIPWASMQNSIDDFRRSTGGnlthnsyiyltglsTATSa---DA-Ansts-----saskRSVdlvyr-------- 294 
XP_002564816  234 MWSTGMIPWPGLLQSIDNFRAATGGnlttes---yeylkNQSMthsSssst---------nttkRSWdytle-------- 293 
EME48537      338 hplirniaseiygrdysivlsrdvlqktvertlHARDntiad-------asdgyKWyGQPVHnGLPL------P-GnysG 403 
EMT61990      312 -----------------------------lanlAIRGvetsvg-----------------dtseseGgqslknQtLsvsG 345 
EJP64554      300 ------------------------------atiALRDietsvn-----------------steatkSpss---fqQtaqG 329 
XP_006674730  296 ------------------------------aaiVLRDietsvn-----------------atddahGgtn---fqKtvqG 325 
EFY90929      315 ------------------------------vdlANRAvdtsvn---------------stdpvgSSDsnd---lqHkvkG 346 
CCE30584      318 ------------------------------vdlASREietsvn--------------stepvsSGSDtne---lqHkvkG 350 
XP_014175070  313 ------------------------------gvqVVREiatsvngsststttaitKA-ENA------Teqs---fqKtvsG 352 
XP_007789141  307 ------------------------------adlVRRQletgvne----tatedaAA-ATG------Tqss---fqAsvsG 342 
EPS31243      295 -----------------------------aaglVIRSlevsetnvs---dstatanaTSSASsGSGSlte---cgDvvsN 339 
XP_002564816  294 -----------------------------fgqmVRRSveasa-----------ddsvSESDSsSDSDes-----sStvsD 328 
EME48537      404 FAGTLAEEGIAVSNAFMTGFLWFLILLVLMVASVAGFKWMLECLTRLKwIREDKLKYFRNHWLGLAGIVALRTWFIGWFI 483 
EMT61990      346 ISAYIQQYSVPKSNTFMMVLLVVAIIIATIIVSILLVKAILEFWALFG-SFPQSLAGFREHYWGSIARTITHLILVLYGI 424 
EJP64554      330 IEKYARQLAVPKSDIFMMALLVVAIIIASIVLVMVLVKVILEAWAIWG-TFPESLKGFRKHYWGSIARTITNLILLLYGI 408 
XP_006674730  326 IEGYARRLSVPKSDIFITALLVVAIIIAAIVVVILLVKVILEAWAIWG-TFPQSLKGFREHYWGSIARTITNLILLLYGI 404 
EFY90929      347 IQAFAEKLLVPKSNIFMTALLIVAIIIAAIVVGILLVKVILEAWALFG-SFPEGLRGFRKHYWGSIARTITSLILLLYGI 425 
CCE30584      351 IQAFAEQLLVPKSNIFMTALLLVAILIATIVLGILLVKVILETWALFG-SFPQSLKGFRKHYWGSIARTITSLILLLYGI 429 
XP_014175070  353 IKAFVEELSIPSANTFMTVLLIVAIVVAVITVGLLFFKVVLEVWSLVG-RFPESLTPFRKHYWRSIGQTLTTLVLLLYGV 431 
XP_007789141  343 FEAYAEELAVPSANSFMTVLLITAIIIGVIIVGLLLVKVILEAWSLWG-SFPQGLTGFRKHYWGSIARTITSLILLLYGI 421 
EPS31243      340 FKCYAQEVMIPSANVFMTILLVFAIVVAVIVVGILLLKVILELWALYG-NFPKSLTNFRNDYWGIMARTITNMILVLYSI 418 
XP_002564816  329 LKQVAQDLMVPSADVFMTVLVIFAIVIAVVVVGILLMKVVLEVWALYG-NFPDKLSDFRKDYWGLMARTITNMILVLYSI 407 
EME48537      484 LMFLTIFQFTYDS-SGGVKGIAAIVFIICFlgmpaiaayavwykwciadneadrangfernkllgGkfpV-PWFgkkqpq 561 
EMT61990      425 WVLYCVFQFTVGD-SWAAQLLAGVTLAIFT-----------------------------------A---IlGWF------ 459 
EJP64554      409 WVLYCVFQFSRADsSWVAKLLAGITLAIFS-----------------------------------G---VlGFF------ 444 
XP_006674730  405 WVLYCIFQFSRADsSWAAKTLAGVTLALFT-----------------------------------G---VlAFF------ 440 
EFY90929      426 WVLYCVFQFTHGD-NTIAKVLAAVTLAIFT-----------------------------------G---IlAFF------ 460 
CCE30584      430 WVLYCVFQFTRGD-SVVAKTLAGVTLAIFT-----------------------------------G---IlGFF------ 464 
XP_014175070  432 WVLYCMYQFTRGD-SWAVKLLAGLTLATFT-----------------------------------G---IlAFF------ 466 
XP_007789141  422 WALYSVYQFTHGD-SWAAQTLAGVTLAVFS-----------------------------------A---VlAFF------ 456 
EPS31243      419 WVLYCVYQLRNGD-SWAAKVLAAVTLGLFT-----------------------------------A---VlAFF------ 453 
XP_002564816  408 WVLYCVYQLRKGD-SWAAKLLAAITLSLFT-----------------------------------A---LlLFF------ 442 
EME48537      562 tnveeqgvrrkdgengtsnvpFWKRMTSGGAVNSKR----SIHDDEDYTKKFGWLASRFRRTRWWFFTFWLFYEFIRAIF 637 
EMT61990      460 ---------------------TWKIFSTVRKLKSTEgnadALYNDKEIWVKYSLFYESYKKDYWWIFIPTIVYLFAKGCT 518 
EJP64554      445 ---------------------AWKIYSTVQKLKAVEgdakGLYDDKELWTKYSLFYDAYSKGYWWLFIPVIVYMFAKGAC 503 
XP_006674730  441 ---------------------TWKIYSTVQKLKNAEgdvsGLYEDKALWTKYSLFYDAYRKNYWWLFIPVIFYMFAKGAC 499 
EFY90929      461 ---------------------SWKIWSVVHKLKKQDgdaaAMYEDKKIWVKYSLFYESYKRQYWWLFVPAIFYMFAKGVA 519 
CCE30584      465 ---------------------TWKIWSVVHQLKQKEgdvdAMYSDKSIWVKYSLFYDAYKKQYWWLFVPTIFYTFAKGVA 523 
XP_014175070  467 ---------------------TFQIGNTAKKLQEAEgdvgGLFENKRLWDRYSMFYESYRRRYWWIFLPTILYMFVKGVV 525 
XP_007789141  457 ---------------------AWKIWSEVRKLKQREgdasGLYDDKATWTKYSLFYESYKRDYWWMFIPLIVYMFAKGTI 515 
EPS31243      454 ---------------------AWRIVHLAHKYKKTEgdiaRLYEDRETWRKYSLFYDCYKKDVWWLFIPVIVYALAKGCI 512 
XP_002564816  443 ---------------------AIRIVYMARKYKKAEgdtdSLYEDKETWRKYSLFYDNYKKDFWWLFIPVIIYALVKGCI 501 
EME48537      638 YAGASGYAKAQVFGLLVVEILAFAFILWVRPFEGQRLNIIVVyCLGFSKVASVALSAAFDVEFNLQRITTTVIGIVIIVI 717 
EMT61990      519 LAVGDGNGMAQTIAQLVVESIFLCLLVWTRPFERKSSNIIGI-AIQTVRVLSVALILVFVHELKIPQDSKTIAGVVLIAV 597 
EJP64554      504 IAAGDGHGMQQTIAQLVIEGCMLGLLLWSRPYERRSGNVLNI-IIQTIRVLSVACILIFVEEFGIAQTTKTVTGLVLIIV 582 
XP_006674730  500 IALGDGHGMQQSIAQLVIEACMLILLLWSRPFERRSGNVLNI-IIQTIRVLSVGCILIFVEEFGIAQTTKTVTGVVLIAV 578 
EFY90929      520 IAAGDGHGMAQTIAQLVIEALMLCLLLWSRPFERRSGNVINI-VIQVVRFLSIACILVFVQEFGIKQTTQTVAGVVLIAV 598 
CCE30584      524 IAAGDGHGMAQTISQVVIEGLMLCLLLWSRPFERRSSNIINI-IIQTVRVLSICCILVFVEEFGIKQTTKTITGVVLIAV 602 
XP_014175070  526 LAVGDGHGLAQTVSQMLIEIGMLALLCWSRPYERRSGNVINI-MIQVVRVLSIVCVFIFVDEFDIAETTQTVAGVVLIVV 604 
XP_007789141  516 LASTDGNGLAQSIALMVVEGLMLGLLIWSKPFERKSSNVINI-TIQVVRVLSVVCILFFVEEFGVAETTQTVTGVVLISI 594 
EPS31243      513 IAGAEGHGMVQTIGQLVVECCMLALLLWNRPYATKSSMGINM-TIQIVRVLSVICVLVFVEELGLSQTTKTVTGVVLIVV 591 
XP_002564816  502 IAGGQGHGLFQSAGQLACEILLLGLLVWSRPYATKASMGINI-AVQVVRVLSIACVLVFVEELGLSQTTKTVTGIVLIVV 580 
EME48537      718 QGFLTIITMIAIVVGAISSYMSVSRNQeDFRPrkWHSLREKYF 760 
EMT61990      598 QSALTGLLVILIIWNAINVLVKENPHR-KRRKe-MEKAKRD-M 637 
EJP64554      583 QSTLTGLLAILVAWNAISACITANPHR-LRRKe-MEKRNRE-L 622 
XP_006674730  579 QSTLTGVLAILIAWNAINACITANPHR-ARRKe-MEKRNRE-L 618 
EFY90929      599 QATLTAVLAILIAWNAINACCKMNPHR-KRRKe-AEQLKRD-M 638 
CCE30584      603 QSTLTATLAILIVWNALTVCCTMNPHR-KRRKe-AEKIRRD-M 642 
XP_014175070  605 QSVLSAALAILMGWNALIACIKENPHK-KRQRe-IEEA-RD-N 643 
XP_007789141  595 QSALTGILALLIVWNAIIACVKMNPHR-QRRKe-MEKMQREGH 635 
EPS31243      592 QSTLTGVLAILIAINAIIVCVRENPHA-KKLRe-AEKANKD-L 631 
XP_002564816  581 QSTLTAVLAILIAVNAFITCCRENPHA-KARRe-AEKANRD-I 620 
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