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Domain of Unknown Function (DUF902) This domain of unknown function is found in several transcriptional co-activators including the CREB-binding protein, which is an acetyltransferase that acetylates histones, giving a specific tag for transcriptional activation. This short domain is found to the C-terminus of bromodomains. The 40 residue domain contains four conserved cysteines suggesting that it may be stabilized by a zinc ion. In CREB this domain is to the N-terminus of another zinc binding PHD domain. |
Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.",