5O6B,5FHH


Conserved Protein Domain Family
PIF1

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pfam05970: PIF1 
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PIF1-like helicase
This family includes homologs of the PIF1 helicase, which inhibits telomerase activity and is cell cycle regulated. This family includes a large number of largely uncharacterized plant proteins. This family includes a P-loop motif that is involved in nucleotide binding.
Statistics
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PSSM-Id: 399159
Aligned: 13 rows
Threshold Bit Score: 350.133
Threshold Setting Gi: 1312330764
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5O6B_B    2 LSKEQESIIKLA-------ENGHNIFYTGSAGTGKSILLREMIKVLKGiyGRENVAVTASTGLAACNI-GGITIHSFAGI 73   Saccharomyces cerev...
Q8RV60  827 LTVEQRKIYDQIiea-vysNSGGVFFVNGFGGTGKTYLWKTLSTYIRS--RGEIVLNVASSGMAALLLdGGRTAHSRFAI 903  thale cress
Q2A9E0  988 LTDEQKSVYDEIiga-vmgKKGGVFFVYGFGGTGKTFLWNILSAAIRS--RGDVVLNVASSGIASLLLpGGRTAHSRFGI 1064 wild cabbage
Q9ZQR0  802 LTPEQRGVYNEItea-vfnNLGGVFFVYGFGGTGKTFIWKTLSATIRY--RDQIVLNVASSGIASLLLeGGRTAHSRFGI 878  thale cress
Q2A9I1  887 ITDEQRGVYEQIlda-vlnDSGGVFFLYGYGGTGKTFVYRALSSAIRS--KGMIVLNTASSGIAALLLeGGRTAHSRFGI 963  wild cabbage
Q6AUR0  316 LNNSQKEVFNAIyns-ainNEGRTFFVYGYGGTRKTFLWTTLLNSIRS--QGKIALVVASSGIASLLLpGGRTPHSRFKI 392  Japanese rice
Q7XW14  932 LNSDQRKVFDTIidr-vsfEKPGFFFVYGHGGTGKTFLWNAIILKIRS--EQKIVLAIASSGVASLLLpRGRTAHSRFKI 1008 rice
Q53R78  812 LNANQKTIFDKIvgs-vvaNQPGFFFVCGHGGTRKTFMWNAIIAKIRS--SNKIVLAVASSGVASLLLpKGRTAHSRFKI 888  Japanese rice
Q9N4X4  922 LNDQQKRAADQIlaalddaSLPRLFYLDGPGGSGKTYLYITLYNICVG--RGLKVACTAWTGIAANLLpLGRTSASLFKL 999  Caenorhabditis elegans
Q5VR06  936 LNDDQKKAFHLIvns-vinKESNFFFVSGHGGTGKTFLWNTIVSFLRA--KKEIVLTVASSGVASLLLpNGRIAHSRFRI 1012 Japanese rice
5FHH_A    8 LSEEQAAVLRAV-------LKGQSIFFTGSAGTGKSYLLKRILGSLPP--T--GTVATASTGVAACHI-GGTTLHAFAGI 75   human
Q2R1R7 1140 LNAEQKVAFDSIies-tnkGLGKLMFVDGYGGTGKTYLWRAITTKLRS--EGKIVLTVASCGIAALLLhGGRTAHSRFHI 1216 Japanese rice
Q337N5 1038 LNIEQKKAFDAIies-ahqSLGKLIFVDGYGGTGKTYLWKAITTRLRS--EGKIVLAVASSGVAALLLqGGRTAHSAFNI 1114 Japanese rice
5O6B_B   74 GLGKGDADKLykKVRRSRKHLRRWENIGALVVDEISMLDAELLDKLDFIARKIRKN------HQPFGGIQLIFCGDFFQL 147  Saccharomyces cerev...
Q8RV60  904 PLQVNETSTC--SISPDSDLASLLLRAKLIIWDEAPMLHRHCYEALDRTLKDIVQAd----nHKPFGGKTITFGGDFRQI 977  thale cress
Q2A9E0 1065 PLNPDEFSTC--NIEPGSHRSELISRASLIIWDEAPMMSKHCFEALDRTMCDIMNTt----dDKPFGGKTVVFGGDFRQI 1138 wild cabbage
Q9ZQR0  879 PLNPDEFSVC--KIKPKSDLANLVKKASLVIWDEAPMMSRFCFEALDKSFSDIIKNt----dNTVFGGKVVVFGGDFRQV 952  thale cress
Q2A9I1  964 PIDADEFSTCk-KMEPGSDRAELVKAAKLIVWDEAPMMSRHCFETLDRTMRDIIRSc----eDKPFGGKAVVFGGDFRQI 1038 wild cabbage
Q6AUR0  393 PLEISQNSMC--SIKKNTNLAELIQKTSLIVWDEAPVNHKYCFESLDRTLRDILSEtnpnslDKQFGGITVVLGGDFRQT 470  Japanese rice
Q7XW14 1009 PIDISENSIC--SIRRGTILAELIQKTLLIIWDEAPMTHRLCFEALDRTLRDLLSEhdpanaIVPFGGKVIVLGGDFRQI 1086 rice
Q53R78  889 PIDINETSLC--NVKRGTMVAELLENTSLIIWDEAPMTHRRCFEALDRTLRDILSEitpsnvIIPFGGKTVVLGGDFRQI 966  Japanese rice
Q9N4X4 1000 DIRNQCKSSL---HQRQLKEAQELAENDVFIWDEASMVPKTALDTVDVLLRDLTKi------DQPFGGKILILGGDFRQI 1070 Caenorhabditis elegans
Q5VR06 1013 PVDIDELSLC--DIKRGTKLAELLIETSLIIWDEALMTNRQCFEALDRTLRDILSEkyinaiDKPFGGKVVVLGGDPKQI 1090 Japanese rice
5FHH_A   76 GSGQAPLAQCv-ALAQRPGVRQGWLNCQRLVIDEISMVEADLFDKLEAVARAVRQQ------NKPFGGIQLIICGDFLQL 148  human
Q2R1R7 1217 PLIVTEESTC--DIKQGSHLAELLKKTSLILWDEAPMANRICFEALDRSLRDILRSkgednsTKPFGGMTVVLGGDFRQI 1294 Japanese rice
Q337N5 1115 PINLTDEYTC--FIKQGSHIADLLMKTSLILWDEAPMANRNCFEALDKSLRDVQRCrnenscQKPFGGMTVVLGGDFRQI 1192 Japanese rice
5O6B_B  148 PPVSKDPNRPTKFAF---ESKAWKEgVKmTIMLQKVFRQRGd----------VKFIDMLNRMRLGNIDDETERE------ 208  Saccharomyces cerev...
Q8RV60  978 LPVITKGSREQIIHAsltSSRLWNS-CK-VLTLTKNMRLTAdpte---kdniKEFSDWILKLGDGKLSEPNDGEaaidip 1052 thale cress
Q2A9E0 1139 LPVIPRGNRADIVMAalnSSYLWKY-CK-VLQLTKNMRLFSetdvh-eaeeiKAFSKWILDLGDGKINEPNNGEtlidip 1215 wild cabbage
Q9ZQR0  953 FPVINGAGRAEIVMSslnASYLWDN-CK-VLKLTKNTRLLAnnlseteakeiQEFSDWLLAVGDGRINESNDGVaiidip 1030 thale cress
Q2A9I1 1039 LPVIPGGGRAETVLAalnSSYLWEH-CK-VLKLTKNMRLLAgltdd-aakelESFSNWILDIGDGKINLPNDGQveigip 1115 wild cabbage
Q6AUR0  471 LPVIQNATKQQILRScivNSYLWNK-CI-LIELTENMRLTSasisaqdreelRNFSNWLLKIGNGTEPFVDVPEqltnmf 548  Japanese rice
Q7XW14 1087 LPVIQKGSRASIDDAsitNSPLWRH-VK-LLSLKINMRLLRsgltqtkkdelDNFAKWVLHIGNGDVPATQREReteptw 1164 rice
Q53R78  967 LPVVPKGSRSAIVDAlitNSKLWKH-VV-MLRLNVNMRLLNpslpstqreelSDFSKWVLAVGDGTLPATKRDGesqpsw 1044 Japanese rice
Q9N4X4 1071 LPVVERSSRADQVDAcikRSPLWTE-FQ-ILHLISNMRVTSg---------dSDWIQFLLNVGDGSANDSDskvtlp--- 1136 Caenorhabditis elegans
Q5VR06 1091 LPVIENASKLEIINAsivKSYLWGY-VK-KIFLFENMRLQKtksntleykeiNDFNNWILDIGNGKINTKQSTAqnedtd 1168 Japanese rice
5FHH_A  149 PPVT-KGSQPPRFCF---QSKSWKRcVPvTLELTKVWRQAD-----------QTFISLLQAVRLGRCSDEVTRQl----- 208  human
Q2R1R7 1295 LPVVRKGRRTQIVNAsikRSYLWQH-FH-IFKLTRNMRLSCisrdedeqkrtADFAQWILNIGDGKTTSADGEewieipd 1372 Japanese rice
Q337N5 1193 LPIVPKGRREHTVNAtikCSYLWQH-FE-VFNLTKNMRLNYvskdqtehqksAEFAEWILQIGNGDTISLDEKgwvrmps 1270 Japanese rice
5O6B_B  209 -------------------FKKLSRPLPDdeIIP-----------AELYSTRMEVERANNSRLSKLPGQVHIFNAIDG-- 256  Saccharomyces cerev...
Q8RV60 1053 edm-------llldslhpiDSIANCVYPN--LLQnlndqtffrerAILCPTNDDVSEVNNHIMDLLPGEVKEYFSSDKic 1123 thale cress
Q2A9E0 1216 kdl-------litqcsepiESIVSEVYGD--TFKdsndpiffqerAILCPTNQDVDVINNYMLDHLTGDERIYLSSDSvd 1286 wild cabbage
Q9ZQR0 1031 edl-------litnadkpiESITNEIYGDpkILHeitdpkffqgrAILASKNEDVNTINEYLLDQLHAEERIYLSADSid 1103 thale cress
Q2A9I1 1116 sdll------iqnsgedpiETMAKEVYGQ--AFQtstdkdlyrhrAILTPTNDEVDKINDYMLSQLPGEEKVYLSSDSii 1187 wild cabbage
Q6AUR0  549 iempq---slllspdcrnlDGLISFVYNL--GCQpsnltsylcerAILAPTNEVVSEINNRMIAQLEASEMSYYSSDSid 623  Japanese rice
Q7XW14 1165 veipq---dlliktdgdkiPALIDEVFPD--LLHnhtdptylscrAIVCPNNGTVDDINNYVVGLLPGEEKEYLSCDTia 1239 rice
Q53R78 1045 itipd---dllvmtdgdkiVAVVSEVYHD--FLAcyknpeylasrAIVCPSNSVVDEINNYVVSLIPGDEKEYLSYDTis 1119 Japanese rice
Q9N4X4 1137 -------------lsvmcdHNIVEEVFGA--VIDpttsd--pcdnVILTPKNVDVAQLNDDVHNRMVGEERIYLSRDEvi 1199 Caenorhabditis elegans
Q5VR06 1169 ttiilvpenllintgenklEELVKFTYPD--FKNsffnpnylknrAILATTNEIVDEVNNYILSLVPNQEKEYYSADTls 1246 Japanese rice
5FHH_A  209 -------------------QATASHKVGRdgIVA-----------TRLCTHQDDVALTNERRLQELPGKVHRFEAMDS-- 256  human
Q2R1R7 1373 dl--------ilkkggdpkEEIVKSIYPN--LVQnykkrdfleqrAILCPRNETAREINEFIMNMIEGEEITYLSCDTvc 1442 Japanese rice
Q337N5 1271 dl--------llqkgddpkAQIIESTYPD--LQDncckqnyleerAILCPVNENVNELNEYIMDQIQGDKVTYLSRDSvs 1340 Japanese rice
5O6B_B  257 ---------GALEDEELKERLLQNFLAPKELHLKVGAQVMMVKNLDAT--LVNGSLGKVIEF 307  Saccharomyces cerevisiae S288C
Q8RV60 1124 dfd-tsverDANMSTEFLNAIKCSGVPNHVLRLKLGVPVMLIRNLDQKygLCNGTRLQVTQL 1184 thale cress
Q2A9E0 1287 psd-lnskdDSVFSPKFLNSIKTSGLPNHSLRLRIGTPVMLLRNIDPDvgLCNGTRLQITQL 1347 wild cabbage
Q9ZQR0 1104 ptd-sdslsNPVITPDFLNSIKLPGLPNHSLRLKVGAPVLLLRNLDPKggLCNGTRLQITQL 1164 thale cress
Q2A9I1 1188 psd-vdieeNVVYPAEFLNSVKVAGLPRHCLKLKVGAPIMCLRNMDVAngLCNGIRLIVTQL 1248 wild cabbage
Q6AUR0  624 dsstnctaiEALYPTEFLNTISINGLPEHVLHLKIGVPIMLLRNLDPSigLCNGTRLIVTQL 685  Japanese rice
Q7XW14 1240 kssehipdlDLLYPTEFPNSINVNNFPNHRLVLKKGVIIMLLRNLNQSmgLCNGTRLLINVL 1301 rice
Q53R78 1120 kcseqipdfDLLYPTELLNSIDANNFPTHRLVLKEGVTVMLLQNLNQSmgLCNGTSLLVVGL 1181 Japanese rice
Q9N4X4 1200 ve---hqadTMHYPTEFLNKMSPSSLPPHILKLKKGSVIILLRNLDVSagLCNGSRFIVETL 1258 Caenorhabditis elegans
Q5VR06 1247 qcmdttndaDILYPVEYLNSLNANNFPTHVLKLKVGVPIILLRNLNQNlgLCNGTRLIITNL 1308 Japanese rice
5FHH_A  257 -------------NPELASTLDAQCPVSQLLQLKLGAQVMLVKNLSVSrgLVNGARGVVVGF 305  human
Q2R1R7 1443 kattndsetDVLYPTEFLNSLNFPGMPNHVLKLKLGLPVMLLRNINQSsgLCNGTRMTITQL 1504 Japanese rice
Q337N5 1341 ksvsyshemEMLYPTEFLNSLNHSGIPNHQLKLKVGLPVMLLRNINQSagLCNGTRMTITRL 1402 Japanese rice
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