1TH1


Conserved Protein Domain Family
APC_r
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pfam05923: APC_r 
APC repeat
This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Links
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Statistics
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PSSM-Id: 399133
Aligned: 43 rows
Threshold Bit Score: 32.8088
Threshold Setting Gi: 190628117
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1TH1_C         10 SPPEHY-VQETPLMFSRCTSVSSL 32  
XP_028026269 1234 ERVSRFvVEHTPAQFSANTSLSSL 1257 wild silkworm
XP_001955695  721 DKLNRFhVEHTPAVFSCATSLSNL 744  Drosophila ananassae
XP_017867251 1093 DDLSKFnVENTPAQFSGATSLSNL 1116 Drosophila arizonae
XP_011747092 1398 AGSVRFtVEKPDENFSCASSLSAL 1421 pig-tailed macaque
XP_022536604 1459 DTLIHFaTESTPDGFSCASSLSAL 1482 Mexican tetra
XP_014283782  792 DSVVAFkEESTPAQFSTATSLSDL 815  brown marmorated stink bug
XP_008198134  326 DAVKKFeTERTPSHFSTATSLSSL 349  red flour beetle
XP_001687753 1186 DELNPYyIEDSPCNFSTVSALSDL 1209 Anopheles gambiae str. PEST
XP_017142970 1231 DEMSKYlVEDSPCNFSVVSGLSNL 1254 Drosophila miranda
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