3EBQ


Conserved Protein Domain Family
Peptidase_C97

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pfam05903: Peptidase_C97 
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PPPDE putative peptidase domain
The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p).
Statistics
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PSSM-Id: 399119
Aligned: 30 rows
Threshold Bit Score: 88.1536
Threshold Setting Gi: 56755846
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3EBQ_A      9 YPVKLYVYDLS---KGLARRL-------------SPIMLGKQLEGI--WHTSIV-------VHKD-EFFFgS-------- 54   human
O56042   1040 HSYATISYDYVlpkTGGNRRVlcfagvgdpnpynLP--TGDKNVGIgsYMVEFD-------IIGL-DKDTgVkvmrpvpw 1109 Rice ragged stunt...
Q8LN31      2 KEVVLHVYDVTnsdSEKTNNTilqi------nriFKDRIG--LGGI--FHSAVQ-------VYGEeEWSFgFce------ 58   Japanese rice
Q9SZZ4      2 AEVVLHIYDVTnsgSEKTNNTivqi------nrfFKDGIG--LGGI--FHSAIQ-------VYGNdEWSYgYce------ 58   thale cress
Q7SF35     22 TEILINVYDLL---PPGRISS-------------TLWFLG--T-SL--LHSGVV-------INGR-EYAYgGhth----r 68   Neurospora crassa
Q8X1T0      1 MKVYINVYDLMpdsPVNK----------------LAWTLGL---GI--YHTGLV-------LEGK-EYAFgAhei----p 47   Schizosaccharomyc...
O49393     17 VPVYLNVYDLTpmnV-------------------YGYWLGI---GI--YHSGLE-------VHGV-EYGYgAhek----- 59   thale cress
Q6NQ19     18 VPVYLNVYDLTpinG-------------------YAYWLGL---GI--YHSGVE-------VHGV-EYGFgAhdh----- 60   thale cress
Q8LA90     15 VPVYLNVYDLTpinG-------------------YAYWLGL---GV--YHSGVE-------VHGI-EYAYgAhey----- 57   thale cress
BAD72532   44 SPVYLNVYDVTpanG-------------------YARWLGL---GV--YHSGVQgmyallsSPSI-LYAYgAhdg----- 93   Japanese rice
3EBQ_A     55 --GGIS------------------SCPPGGt----LLG-PPDSVV-----DVGSTEVTEEIFLEYLSSLGESlFRGEAYN 104  human
O56042   1110 kqCGYTeeqvwsiyktlgkeyrkvELKPYTvedawRVIaKSSHKRvlsdkAIISTPISYERQRAIEYMLSS---HGFDYN 1186 Rice ragged stunt...
Q8LN31     59 ngSGVF------------------SCPIGK-----NPMyTYRECI-----VLGETECSIATVNRILRELSRE-WPGHSYD 109  Japanese rice
Q9SZZ4     59 qgTGVF------------------SCPSGK-----NPMyTYREKI-----VLGKTDCTIFMVNQILRELSRE-WPGHTYD 109  thale cress
Q7SF35     69 gkTGVY------------------WTAPRTe----PPGgTFRCEL-----LHGFTLATPAEIDAIIREASEE-FLGTAYN 120  Neurospora crassa
Q8X1T0     48 gsTGVF------------------ATMPRPp----LEGcRWRCSI-----ALPNCTLPKPDVDRILIRLSQE-FTGLSYS 99   Schizosaccharomyc...
O49393     60 ssSGIF------------------EVEPKK-----CPGfTFRKSI-----LVGETEMKAKEVRSFMEKLSEE-YQGNKYH 110  thale cress
Q6NQ19     61 stTGIF------------------EVEPKQ-----CPGfTFRKSI-----LIGRTDLDPENVRVFMEKLAEE-YSGNSYH 111  thale cress
Q8LA90     58 psTGIF------------------EGEPKQ-----CEGfTFRKSI-----LIGKTDLGPLEVRATMEQLADN-YKGSSYN 108  thale cress
BAD72532   94 agSGIF------------------EVAPRR-----CPGyAFREAI-----LVGTTELTRAEVRAVMADLAAD-FPGDAYN 144  Japanese rice
3EBQ_A    105 LFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFgqalRPLLD 151  human
O56042   1187 LVLNNCQDFTRGLFDYARGGPVPDFIENDVRIAMIHSTsr---hfAE 1230 Rice ragged stunt virus (isolate Thailand)
Q8LN31    110 LLSRNCNHFCDVLCERLAVPKLPGWVNRFANAGDTAVVvaenTAVKF 156  Japanese rice
Q9SZZ4    110 LLSKNCNHFCDVLCDRLGVPKIPGWVNRFAHAGDTALEvagnTAMRV 156  thale cress
Q7SF35    121 LLTKNCNHFTSHLCQKLTGLPGPAWLNRAASIGV---AlpcmVPKDW 164  Neurospora crassa
Q8X1T0    100 LLERNCNHFTNAAAIELTGSPIPSFLNRISRIGLAFPTi---TNALL 143  Schizosaccharomyces pombe 972h-
O49393    111 LITRNCNHFCNHVSLKLTHKSIPSWVNRLARLGF---LcncvLPACL 154  thale cress
Q6NQ19    112 LITKNCNHFCNDVCVQLTRRSIPSWVNRLARFGL---FcncvLPAEL 155  thale cress
Q8LA90    109 LITKNCNHFCDETCIKLTGNPIPSWVNRLARIGF---McncvLPATI 152  thale cress
BAD72532  145 LVSRNCNHFCDAACRRLVRARIPRWVNRLAKIGV---VftcvIPGNG 188  Japanese rice
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