Conserved Protein Domain Family
Ceramidase

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pfam05875: Ceramidase 
Ceramidase
This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23. This family belongs to the CREST superfamily, which are distantly related to the GPCRs.
Statistics
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PSSM-Id: 399108
Aligned: 156 rows
Threshold Bit Score: 155.394
Threshold Setting Gi: 110832730
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006675514  17 YWGAPSSSVDWCEMNYEVTTFIAEYFNTISSFAMAVVGMLGVvlhpWAEM--------RFHMAFQTTVAVGLGSVAFHCT 88  Batrachochytriu...
XP_002111074   3 HFARGSSRVDWCETNYVQSSYIAEFYNCASNILFFVVPPILM----CLFRpytkcingNMNVVLVLMMFVGLSSVYFHAT 78  Trichoplax adha...
XP_002609821   4 eFERGSSDVDWCEANYDIVPAIAEFWNTISNFLFIVLPPVLM----YLFRpyarqvnaSINLIWWMLAVVGISSAYFHAT 79  Florida lancelet
XP_011662777  40 nleRGSAAIDWCENNYAIVPGIAEFYNTVSNILFFVIPPLLL----YLFRqyavrynwHVNIMWILLMVVGIFSCYFHAT 115 purple sea urchin
XP_001363180   9 qlRAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICM----CLFRqyaacfnsGIYLIWTLLVVVGIGSVYFHAT 84  gray short-tail...
OWR50286       4 HLERGSSPVDWCESNYSISPVIAEFVNTISNILFFLFPPVLI----HLFQeyarffnpAINVLWVLLMVVGISSAYFHAT 79  Danaus plexippu...
XP_001606736   4 pFEPGSSPIDWCEGNYNISPSIAEFMNTLSNIVFLLLPPVLM----HLFRdygrfvnpGIHVIWLLMMVVGASSAYFHAT 79  jewel wasp
Q29KK7        19 HLRPGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLM----MLFKeygrfvtpGIHVIWLLLIVVGLSSMYFHAT 94  Drosophila pseu...
Q17KM2         5 HLERGSSPVDWCEGNYLISPDIAEFVNTVSNILFLVGPPFLI----YLFKdygkfiqpAIHMIWILLIIVGLSSAYFHAT 80  yellow fever mo...
XP_018672835   8 dFLPHSSEVDWCENNYATIPIIAEFWNTVSNSIFFIIPPLLI----YLFKqysrqvcsSVNLVWVLLIFVGAGSVYFHST 83  vase tunicate
XP_006675514  89 LGKFSQALDEVPMLYSALAFTYIGICEr--ySPSAR--------VRRFLAIGLTFHAIFTTLLVTMseGFwqfFLFHVSF 158 Batrachochytriu...
XP_002111074  79 LSLLGQLVDELSILWLMASAFGYWLP------QRILkqmpvingSRVIFQRVVFTVAGITTILSCI--KP---EINAFVL 147 Trichoplax adha...
XP_002609821  80 LSLVGQLLDEIAILWVIIAAWGVWAP------RRFFprf--cneSRKSFMLLMLGAGAITTILAFL--HP---SMNHFLL 146 Florida lancelet
XP_011662777 116 LSMFGQLLDEVAIIWVVLCGVALWYP------RRYYpan--ikgSRKKFKWIMLLFTVASTCLAMV--RP---AVNSFVM 182 purple sea urchin
XP_001363180  85 LSFLGQMLDELAILWVLMCALAMWFP------RRYLpkv--frnDRGRFKIVVCVLSGITTCLAFV--KP---AINNISL 151 gray short-tail...
OWR50286      80 LSLVGQLLDELAILWVFMAAFAMFLP------KRHFprf--lggNRRVLAFYSSVFSVVSTGFLVM--HP---KANAFAL 146 Danaus plexippu...
XP_001606736  80 LSLVGQLLDELTILWVYMAGFCMFFP------RRYFpta--aknNRKRFSLFATLPTLVATVLATF--HP---AINAFAL 146 jewel wasp
Q29KK7        95 LSLIGQLLDELAILWVFMAAFSLFYPKryypKFVKN--------DRKTFSWLMLLSAIAATALSWW--KP---VVNAFVL 161 Drosophila pseu...
Q17KM2        81 LSLLGQLLDELTILWVFMATLSLFCP------RRHFpri--fkySRKRFCISMTVFSLTATALSVC--YP---AINAFAL 147 yellow fever mo...
XP_018672835  84 LSLVGQLIDEIAILWVCLAALATWLP------SKYLpsi--lrsDRRNFQAIIAGVAVVSTCLALV--KP---ELNHGLL 150 vase tunicate
XP_006675514 159 GTAQLFAIVQVICIYrdreiphqfksgiiqrseitesskhrkhthdrkislenailsetkqllnthhdcadsisdhsvyD 238 Batrachochytriu...
XP_002111074 148 LSFGLPFVVIAAREV----------------------------------------------------------------R 163 Trichoplax adha...
XP_002609821 147 MPLAIPSLMCMFSEL----------------------------------------------------------------K 162 Florida lancelet
XP_011662777 183 MSFIGPCICMMVLEL----------------------------------------------------------------R 198 purple sea urchin
XP_001363180 152 MALGIPCTALLIAEL----------------------------------------------------------------K 167 gray short-tail...
OWR50286     147 MMLAFPAIGFLCKEL----------------------------------------------------------------N 162 Danaus plexippu...
XP_001606736 147 MTLGIPAFAFMILEL----------------------------------------------------------------K 162 jewel wasp
Q29KK7       162 MFMGVPTMLMLYREL----------------------------------------------------------------Q 177 Drosophila pseu...
Q17KM2       148 MLLAIPATYLLYKEL----------------------------------------------------------------K 163 yellow fever mo...
XP_018672835 151 FMFGVPGTVLLVLEL----------------------------------------------------------------R 166 vase tunicate
XP_006675514 239 nqraCANDPVALTFQRGILSYGVATFCWLTDMLFCELVnphykgAI--LPFNpqlHAWWHIFVSIGLYHLALLTLAARVD 316 Batrachochytriu...
XP_002111074 164 r---CKCQRVKQLCCSGVLWWCLAVICWISDRCFCDLW------LAlkFPYL---HCAWHLLIAVSSYIGCVICAYIFAA 231 Trichoplax adha...
XP_002609821 163 r---CNDWRVIRLGIAAFVWFSLALTCWLNDRLFCHIW------ESvsFPYL---HSGWHIFIAIASFELCVVMAYFEAV 230 Florida lancelet
XP_011662777 199 r---AHCPRVVKLGKTCALMWVISVSCWLSDRFLCDFW------QSysIPYL---HCAWHIMVFISAYTACVLFAYFDAM 266 purple sea urchin
XP_001363180 168 r---CDNVRVYKLGLFSGLWWMLALFCWISDRAFCELW------SSfnFPYL---HCVWHILICLAAYLGCVCFAYFDAA 235 gray short-tail...
OWR50286     163 r---VKCARVYRLGLRCVAVCCLAIFSWIIDRMFCDAW------LSidFPYM---HGVWHILIFIASYTALVLFAYFNVS 230 Danaus plexippu...
XP_001606736 163 r---TKSARVYRLGLRCGAAWLLAVTCWLNDRLFCDTW------LNlnFPYL---HALWHLFIFIASYTAAVLFAYFSVK 230 jewel wasp
Q29KK7       178 r---VSDQRVYRLGIRCTTVWAVAVFCWINDRMFCEAW------SSinFPYL---HGFWHIFIFIAAYTVLVLFAYFYVE 245 Drosophila pseu...
Q17KM2       164 i---VEDKRVYRLGVRNTTILLVAIVCWINDRMFCDAW------SRmnFPYL---HGFWHILIFISAYTACVLFAYFFVS 231 yellow fever mo...
XP_018672835 167 s---CECPLVLHVGTMSAIWWCVAVLCWVSDRFLCNFl---------qFPYL---HSAWHIMVCLASYMACVCYAYFYAT 231 vase tunicate
XP_006675514 317 SKYGAgravLRFWF--------NIIPYI 336 Batrachochytrium dendrobatidis JAM81
XP_002111074 232 NETPEl--sPKLVYwpv--dnqLGLPYV 255 Trichoplax adhaerens
XP_002609821 231 TMAPEr--aPTLKFwpyd-rcdLGVPYV 255 Florida lancelet
XP_011662777 267 NECPEm--gPVLKYwpkdswvnAGIPYV 292 purple sea urchin
XP_001363180 236 SEIPEq--gPVIKFwpsekwafIGVPYV 261 gray short-tailed opossum
OWR50286     231 EERPEq--kPELRYwprn-dfeLGIPYI 255 Danaus plexippus plexippus
XP_001606736 231 EERPQq--sPMLKYwprd-dfeLGIPYV 255 jewel wasp
Q29KK7       246 SELPQr--qPLLKYwp--------knEF 263 Drosophila pseudoobscura
Q17KM2       232 DERPEs--rPQLKYwpsn-nfeLGVPYV 256 yellow fever mosquito
XP_018672835 232 NEVPEq--cPRLRFwphdrhtwFGIPYV 257 vase tunicate
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