5WWL,5T58


Conserved Protein Domain Family
Mis12

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pfam05859: Mis12 
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Mis12 protein
Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants. It has been shown that Mis12 genetically interacts with Mal2, another inner centromere core complex protein in S. pombe.
Statistics
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PSSM-Id: 399099
Aligned: 107 rows
Threshold Bit Score: 87.6442
Threshold Setting Gi: 548847384
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5WWL_M         1 MLVELLEFTPLSFIDDVINITNQLLYKGVNGVDKAF--------SQTRFAKKAPQEIEEGLHKFEVLFESVVDRYYDGFE 72  Schizosaccharom...
XP_005988630   8 YEAQFFGFTPQTCILRVHNAIKDYLFDMMLLVERVIlkklvelpD----SNISTFQIRESTENFLSFMNERFEQLFNKVE 83  coelacanth
XP_006641036  21 YEAQFFGFTPQTCMLRVYNAFQDSLYEIMLIVETVLvkkirgpeA----AGEVDSQTRQRTQKLLTFLQKRISRLTGRME 96  spotted gar
XP_007245327  21 YEAQYFGFTPQTCMMRVNSAFQDCLYEMLAVVESVFvrklsqgkD---PPEELQVKTRECTQKLLRFLQERFKKLSSRME 97  Mexican tetra
NP_956672     16 YEAQFFGFTPETCTLRVRDAFRDSLNHILVAVESVFvkrlcpgrD---PPAELRLTARESTQKLRQFLQERFEIMFQRMK 92  zebrafish
CAF91621       1 YETQFFGFTPKTCMLRVYSAFQDCLCDILLVVEKVCvrqlskgeS-AAEEEPLQARARECSRKLQQFLEDRFKQLSERME 79  spotted green p...
XP_001198150  34 YETQYFGFTPKSFIDGVYNAVADYLYDSVDAADKYIat-----eAQQGRQPVCTEAVRQSSDRLLAHLQLAFDKAFDRLE 108 purple sea urchin
XP_023280731  32 YEAQFFGFTPQTCMLRVYSAFQDCLYDILPVVEKVCvrqlsrgeS-EGADELLRARARECSRKLQQFLEERFKQLAERME 110 Seriola lalandi...
XP_005027386   8 YEAQFFGFTPQTCMLRIYLAFQDYLLEMMAVVEGVVlkkleaspG----GRVSRLDVRKSTEKFLRFMKEHFDQLFGKME 83  mallard
NP_001016808   8 YESQFFEFTPQTCILRVYIAFQDYLFEMLLVVEKVImkklesmeG----SKISHFQIRESTEKYLNFIKERFNILFQKME 83  tropical clawed...
5WWL_M        73 VYTLRNIFSYPPelkgYMRTFG-----------KDVDYsitteqdaaMDQAIQEAAEKLVVKMQLRRDL 130 Schizosaccharomyces pombe ...
XP_005988630  84 QMLLTLVLKVPE----NIFLPQdkvhkrypyskEQYEQ---------LECEITQLEKRYKAEICAKQTL 139 coelacanth
XP_006641036  97 RFLQSSVLQVPA----NVLLPEdaahqqhprgrERLVK---------LEAELAALQLRYQAEVGARQAL 152 spotted gar
XP_007245327  98 ALLVNSVLCVPE----NLLLPEdeshrkypqsqEQLLK---------LEASITNLQSSYQAEVCARQAL 153 Mexican tetra
NP_956672     93 GMLIDRMLSIPQ----NVLLPEdqmhqkypegkEELTK---------LQESIAKLLQAYEAEVCSKQAL 148 zebrafish
CAF91621      80 VLLLNRCFSVPP----NVLLPEdkchnkypqdiKEALR---------LESCIADTQKALEAEVYARQAL 135 spotted green pufferfish
XP_001198150 109 TYLIKNIFPIPS----HVVLPEdkihgevilmeSDETR---------LDSELEELRHRIRNAQYVNARL 164 purple sea urchin
XP_023280731 111 ALLVNRCFSVPP----NVLLPDdqshknypqdlQEVLK---------LESSLADLQRAYEAEVCARQAL 166 Seriola lalandi dorsalis
XP_005027386  84 EVLLQLVLSIPP----HVLLPEdrvhrqypysrEQFQA---------LQDEASHLQQRCRAEAAAGQAL 139 mallard
NP_001016808  84 SWLLKLVLSIPS----NVLLLEdkvhaqysyskEEFEH---------LQTETETLQKKCKAESLAKQRL 139 tropical clawed frog
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