3DWL


Conserved Protein Domain Family
ARPC4

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pfam05856: ARPC4 
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ARP2/3 complex 20 kDa subunit (ARPC4)
This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion.
Statistics
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PSSM-Id: 399097
Aligned: 38 rows
Threshold Bit Score: 164.688
Threshold Setting Gi: 321438197
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DWL_K         1 MSNTLRPYLNAVRSTLTASLALEEFSSEIVERQSQPEVEV-----------------------GR--SPEILLKPLVVSR 55  fission yeast
Q587H0         1 MSEEELLYYTCIKNTLHAALCIGNYPSRTVERHNKPEVEVsgcae--------------gdneGK--SPELLLNRLHISR 64  Trypanosoma brucei
Q4DTG5         1 MATAYLPYYDCIKCTLHAALCIGNYPSCTVERHNKPEVEVadhle--------------nngeRK--VQDFLLNPIRIVR 64  Trypanosoma cruzi
Q23YX7        48 MSSTLEGYTNALREVLDVSLSLQDFPSEIVEKHNKPEVELhg-------------------ynKT--TKNLVLHPIYLAR 106 Tetrahymena the...
A0BUM1         1 MAAANQVYSDAIRKTLEATLCLRSFPSEIIEKQSKPEIELng-------------------ysSK--TRQLVLSPIYLCR 59  Paramecium tetr...
CBZ11950      29 MTVAKQPYYDCVERTLLVALCLPSFAFDVTQGCTVPEVELvpp------------------dtGTgaPPSSFLVHCATAH 90  Leishmania majo...
XP_002945817   1 MALSLRPYTNNIRTELNKALCIQSFACQNVERHDKPEVES-----------------------RD--NPELLLPPVTITR 55  Volvox carteri ...
XP_002141491   9 agsPLMPYLRRIFNALNKELCLYYSPLYFPSAFSIPSIEDn----------------------PS--NYSSLTKSLYIYR 64  Cryptosporidium...
Q5CUE1        13 sNAPLLPYLRRLFNTLNREICLFYLPLNLPCMYSVPFIEQehliknlssadnidissskksfnRN--NKVELIKSLYVYR 90  Cryptosporidium...
CAM41457       1 MAGEKQLYYDCVERTLLVALCLQSFASDVAEGCAVPEVELmsp------------------ytATdaSPFPFLVHPATAD 62  Leishmania braz...
3DWL_K        56 ------------NEQEQCLIESSVNSVRFSIRIKQV----DEIERILVRKFMQFLMGRAES---FFILRRKPVQ------ 110 fission yeast
Q587H0        65 ------------SEQERCLIEASINSVRISFAFPKM----DPLAELIARKYVSFLAQRGQQ---FRILRKKPIA------ 119 Trypanosoma brucei
Q4DTG5        65 ------------SEQESCLIEPSINSTRISVSFLKS----DAIAEIIARKYVGFLAQRAKQ---FHILRKKPIP------ 119 Trypanosoma cruzi
Q23YX7       107 ------------SDKEKCLVEPSVNSCRISFLLKKN----DELDILIASRFSQYFMVRADQ---FQILRRKAVT------ 161 Tetrahymena the...
A0BUM1        60 ------------GEKEKCVIEPSINSTRISFSIKAL----DDVDRLIGEKFAKYLAVRADY---FEILRRKPIP------ 114 Paramecium tetr...
CBZ11950      91 aalrchalrlqwSSGDECFIEASCDSTRVSFWFAAAhqpgDALSAQLLNEYMAFFCSHSAAtgaLPILRCIPVRrtsagk 170 Leishmania majo...
XP_002945817  56 ------------SEKERCLIEASINSVRVSLRLGQM----DMLEEELVKMYLRFLMQRAEL---LEVARRVPVE------ 110 Volvox carteri ...
XP_002141491  65 ------------HSKEYCLIESCLDSVRISLKFYLM----CKFEQCLFQQAIKFMTKNSDY---FKIIRKKEIL------ 119 Cryptosporidium...
Q5CUE1        91 ------------HSKEFCYIESCIDSVRVSLKFYFK----CEFERRLFNQLTIFMKKNSDY---LQLVRKKSIE------ 145 Cryptosporidium...
CAM41457      63 aslqsnklqlqwSSGDECLVEGSFNSTRVSFWFAAAhqpdDVLSTQLLSEYLAFFCSHGAAtgtLPVLRCAPVRqalmak 142 Leishmania braz...
3DWL_K       111 ---------GYDISFLITNYHTEEM----------------LKHKLVDFIIEFMEEVDAEISEMKLFLNGRARLVAETYL 165 fission yeast
Q587H0       120 ---------GYDISFLITHEEVEVI----------------PRSKIIEFVITFLMEMDKDITLLKINANERARRAARQFF 174 Trypanosoma brucei
Q4DTG5       120 ---------GYDISFLISHEEVETM----------------HRNKIIQFIITFLMDIDADIAAMKLNVNQRARRAAMEFF 174 Trypanosoma cruzi
Q23YX7       162 ---------GYDVSFLITNEHLEKY----------------QKKELIQYIIDFVGNVEKDLSDIKLNIISQARKSATFYA 216 Tetrahymena the...
A0BUM1       115 ---------GYDISFLILDSHLEKY----------------NVQGIINFIIDYVENIDKDLSDIKLNINTQARITAACFV 169 Paramecium tetr...
CBZ11950     171 paadaagrtAYDVSFLVLAEHVCGY----------------GRQHLARSILAFAQEVEAAVASLKVSLNARRRAAAQAFF 234 Leishmania majo...
XP_002945817 111 ---------GYDVSFLITDQHLRVY----------------GKQRLLDFMVAFIEEMDVETSSMKLAVNSRGRAVATEAL 165 Volvox carteri ...
XP_002141491 120 ---------GFDVSFLISYNMFENLhypl---------ispGKYDAINFVLKFIVSIDMQIQKERLQSTYFSRSFAYLLV 181 Cryptosporidium...
Q5CUE1       146 ---------GFDISFLITNHILNSYnnkicisnksnydgqmGKYDVIHFILKFVVDIDRQIQDKMLQSTYFSRYYIRKLL 216 Cryptosporidium...
CAM41457     143 paadaadqvIYDVSFLVLAAHVRQY----------------GRHSLARFIMTFVKEAEATVEMLKASLNSSGRAAAQSFF 206 Leishmania braz...
3DWL_K       166 S 166 fission yeast
Q587H0       175 Q 175 Trypanosoma brucei
Q4DTG5       175 L 175 Trypanosoma cruzi
Q23YX7       217 K 217 Tetrahymena thermophila SB210
A0BUM1       170 g 170 Paramecium tetraurelia
CBZ11950     235 A 235 Leishmania major strain Friedlin
XP_002945817 166 R 166 Volvox carteri f. nagariensis
XP_002141491 182 s 182 Cryptosporidium muris RN66
Q5CUE1       217 Q 217 Cryptosporidium parvum
CAM41457     207 S 207 Leishmania braziliensis MHOM/BR/75/M2904
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