6URO


Conserved Protein Domain Family
Suf

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pfam05843: Suf 
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Suppressor of forked protein (Suf)
This family consists of several eukaryotic suppressor of forked (Suf) like proteins. The Drosophila melanogaster Suppressor of forked [Su(f)] protein shares homology with the yeast RNA14 protein and the 77-kDa subunit of human cleavage stimulation factor, which are proteins involved in mRNA 3' end formation. This suggests a role for Su(f) in mRNA 3' end formation in Drosophila. The su(f) gene produces three transcripts; two of them are polyadenylated at the end of the transcription unit, and one is a truncated transcript, polyadenylated in intron 4. It is thought that su(f) plays a role in the regulation of poly(A) site utilization and an important role of the GU-rich sequence for this regulation to occur.
Statistics
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PSSM-Id: 428647
Aligned: 20 rows
Threshold Bit Score: 262.312
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6URO_E        375 TLVYIQYMKFARRAEGIKSGRMIFKKAR-EDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDY 453 
P0CO12        694 SVVWIMYMRFARRAEGIKAARGVFGKAR-KSPHLTWQVFEASALMEYHTNKDAAVAIRIFELGLKQFSEDVDYVIKYLQF 772  Cryptococcus ...
Q4PCV8        623 ALVWIKYMHFLRRTEGIRPARSVFSRAR-KSPHCTWQVFEASALMEYHCSKDAVVATKVFELALKTFGSDEAFVVRYLDF 701  Ustilago mayd...
EDO40717      391 TLAFIQYMRFSRRAEGVKESRSVFKRAR-EDARTNFHVFVASALMEYYCGKDKAVAFKIFELGLKKYTNEADFVLPYVDY 469 
XP_020797035  375 TLVYIQYMKFARRAEGIKSGRTIFKKAR-EDPRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYILAYIDY 453 
P25991        408 TLVYVQYMKFARRAEGIKSARSIFKKAR-EDVRSRYHIFVAAALMEYYCSKDKEIAFRIFELGLKRFGGSPEYVMCYIDY 486  fruit fly
Q8GUP1        333 SLAHIQYLRFLRRAEGVEAARKYFLDAR-KSPSCTYHVYIAFATMAFCIDKEPKVAHNIFEEGLKLYMSEPVYILKYADF 411  thale cress
P25298        413 TFVFCVYMNTMKRISGLSAARTVFGKCRkLKRILTHDVYVENAYLEFQNQNDYKTAFKVLELGLKYFQNDGVYINKYLDF 492  Saccharomyces...
Q6BJD8        445 TLVYTKLMMACKRSRGIKEARGVFKQARnNFEAIGYEFYVENALMEYH-SDNLKTASKIFELGMKHFKKQGEFLLAYLDF 523  Debaryomyces ...
Q5AM44        482 TLTYVKFMIASKRSEGIKEARNVFKQAR-KFTDIGYQIFIESALLEHY-SDKKSTALKIFDLGKKNFATNGKFLLNYLDY 559  Candida albic...
6URO_E        454 LSHLNEDNNTRVLFERVLTsgS--LPPEK---------------------------------SGEIWARFLAFESNIGDL 498 
P0CO12        773 LLSINDDNNARALFERSVV--R--IMGDK---------------------------------ARPLWDAWARYEYTYGDL 815  Cryptococcus ...
Q4PCV8        702 LISMNDDSNARALFERVIG--T--FAPER---------------------------------ARPIWERWAKYEYNFGDS 744  Ustilago mayd...
EDO40717      470 LSHLNDDNNTRVLFEKVLS--T--MPKEK---------------------------------ASDVWTKFIEFETTSGDL 512 
XP_020797035  454 LSHLNEDNNTRVLFERVLT--SgnLSPEK---------------------------------SGEIWARFLAFESNIGDL 498 
P25991        487 LSHLNEDNNTRVLFERVLS--SggLSPHK---------------------------------SVEVWNRFLEFESNIGDL 531  fruit fly
Q8GUP1        412 LTRLNDDRNIRALFERALS--T--LPVED---------------------------------SAEVWKRFIQFEQTYGDL 454  thale cress
P25298        493 LIFLNKDSQIKTLFETSVE--K--VQDLTq--------------------------------LKEIYKKMISYESKFGNL 536  Saccharomyces...
Q6BJD8        524 LIMINKGESIKVLFEQGLT--A--LLQDVnienensngditsganmrlqeskskenikkkncIKKLIKKFSRYQSVYGDL 599  Debaryomyces ...
Q5AM44        560 LIMINDVDTMRTVIQSSDA--N--FTKEIgnlqeelkltnldpi---trkklekqitnlkkfLKQLYKKYISFAATFLSL 632  Candida albic...
6URO_E        499 ASILKVEKRRFTAFKE---------EyegKETALLVDRYKFMDLYPCSASELKALGYKDVSRAKLAAII----------- 558 
P0CO12        816 SAVHKLEARMSEVFPE---------D---APLKRFAQRWSYNGIDQIAIRDLGFNRARMGVAAPPAFAIapvlppvhasi 883  Cryptococcus ...
Q4PCV8        745 VAIQKLESRLAETYPD---------E---PATKRFIARSSYMDLDLVGPRDLGIRAAMAGASAADRAVEaakdgg-aeeg 811  Ustilago mayd...
EDO40717      513 SSILKVEKRRLQVYKEef------eQ---HETAVLVDRYRFLDLLPCSPMELKIMGYTGPSRHVTSISTa---------- 573 
XP_020797035  499 ASILKVERRRFAAFKDey------eG---KETALLVDRYKFMDLYPCSTSELKALGYKDVSRAKLAALLpet-------- 561 
P25991        532 SSIVKVERRRSAVFENlke----yeG---KETAQLVDRYKFLDLYPCTSTELKSIGYAENVGIILNKVGgg--------- 595  fruit fly
Q8GUP1        455 ASILKVEQRMKEALSGkgeegssppE---SSLQDVVSRYSYMDLWPCTSNDLDHLARQELLVKNLNKKAgkt-------- 523  thale cress
P25298        537 NNVYSLEKRFFERFPQ---------E---NLIEVFTSRYQIQNSNLIKKLELTYMYNEEEDSYFSSGNGd---------- 594  Saccharomyces...
Q6BJD8        600 DLIKSLDSRYEEYFPD---------D---DSIELFSDRYRGHSIDVIKHFDLGKEDTSHEEIDTT--------------- 652  Debaryomyces ...
Q5AM44        633 DVTHSFAKKCEQLFPK---------D---DPIDLFTDRYKLDNINIIKKDELGRDDILTSFDGIIDEEE----------- 689  Candida albic...
6URO_E        559 -PD-----PVVAPSIVPVLKDEVDRKPe-yPKPDTQQMIPF-------------------------------------QP 594 
P0CO12        884 pAPiavptPVQPPQESYKRPAPEDIPP---RRPSSAEFSRSpkrhraqspprryperddrpppgryrdslppvkapssIP 960  Cryptococcus ...
Q4PCV8        812 pRR-----KTMQEMKRLAAESAQDDTSgdwARPGASSSAGGaggppvk-----------------------kfkrdsaSP 863  Ustilago mayd...
EDO40717      574 -----------qSSTDNPLEEVKEEKTvrfPLPDTSQMTp-------------------------------------fKP 605 
XP_020797035  562 ----------vvAPSVPILKDEIDRKPe-yPKPDTNQMIp-------------------------------------fQP 593 
P25991        596 ----------aqSQNTGEVETDSEATPp-lPRPDFSQMIp-------------------------------------fKP 627  fruit fly
Q8GUP1        524 ------------nlPHVPAAIGSVASSskvVYPDTSQMVVQdptkksefassan-----------pvaasasntfpstVT 580  thale cress
P25298        595 -------------gHHGSYNMSSSDrkr-----------------------------------------------lmeET 614  Saccharomyces...
Q6BJD8        653 ------------AQETKRRKIQNPTvdeft--------------------------------------------pevsNN 676  Debaryomyces ...
Q5AM44        690 ------------LQRLKRRKLSNGSGSsssysfne-----------------------------------eesksaikNI 722  Candida albic...
6URO_E        595 RHLAPPGLHPVPGGVFP--------VPPAAVVLMKLLPPPICFQGP---FVQVDELMEIFR-RCKIP 649 
P0CO12        961 PPPLAGPAYATPSSGAYggdkdrsgLEKPLAWFMAQLPNARSFDGP---VFRPDDIMKLFG-GLSLP 1023 Cryptococcus neoformans va...
Q4PCV8        864 APAAFNNQAVGQQVAGPrda--wneFPESVLVFMEMLPSAQLFDGP---MFKPEDIIDCIR-SANVP 924  Ustilago maydis 521
EDO40717      606 TAGAAKCLKIGGGFRAS--------PPPP-------LEPPPLFNGP---FVVIEELMRLFA-ECTLP 653 
XP_020797035  594 RHLAPPGLHPVPGGVFP--------VPPAAVVLMKLLPPPTCFTGP---FVQVDELMETFR-RCTLP 648 
P25991        628 RPCAHPGAHPLAGGVFP--------QPPALAALCATLPPPNSFRGP---FVSVELLFDIFM-RLNLP 682  fruit fly
Q8GUP1        581 ATATHGSASTFDEIPKT--------TPPALVAFLANLPIV---DGP---TPNVDVVLSICL-QSDFP 632  thale cress
P25298        615 GNNGNFSNKKFKRDSE---------LPTEVLDLLSVIPKRQYFNTN---LLDAQKLVNFLNdQVEIP 669  Saccharomyces cerevisiae S...
Q6BJD8        677 NNQHTNNKDAVQNQQQPqn-----fVGNTIYNLLRVLPNSSYFGPPsdhLFNNTKLVELFG---NLP 735  Debaryomyces hansenii CBS767
Q5AM44        723 EEQKTRVQQEQDQENQGinkpeesfVGPSIIALMSALPNASYFGLPsesVFNSEKLVTLFAnLSNIP 789  Candida albicans SC5314
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