Conserved Protein Domain Family
Pro-MCH

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pfam05824: Pro-MCH 
Pro-melanin-concentrating hormone (Pro-MCH)
This family consists of several mammalian pro-melanin-concentrating hormone (Pro-MCH) 1 and 2 proteins. Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic peptide that was first isolated from the pituitary of teleost fish. It is produced from pro-MCH that encodes, in addition to MCH, NEI, and a putative peptide, NGE. In lower vertebrates, MCH acts to regulate skin colour by antagonising the melanin-dispersing actions of small alpha, Greek-melanocyte stimulating hormone (small alpha, Greek-MSH). In mammals, MCH serves as a neuropeptide and is found in many regions of the brain and especially the hypothalamus. It affects many types of behaviours such as appetite, sexual receptivity, aggression, and anxiety. MCH also stimulates the release of luteinising hormone.
Statistics
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PSSM-Id: 399081
Aligned: 4 rows
Threshold Bit Score: 167.806
Threshold Setting Gi: 1043427903
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
OCA40531      84 TIDSQQNYLSHdGLPLNIGIKQMPYLAFRNSLHH-SENEDQNAESAQErRDIGDEENAAKFPVGRRDFDMLRCMLGRVYR 162 tropical clawed...
NP_001182724  81 DTDSRHDFSNH-GVPISVGRKQLPYLALKGAIAFpADTEIQNIESVQE-RETVEEENSAKFPIGRRDFDMLRCMLGRVYR 158 chicken
Q16048         5 KPKKKHNFLNH-GLSLNLVIK--PYLALEGSVAFpAENGVQDTESTQEkRETGDEENSAKFPVGRRDFDTLSCMLGRVYq 81  human
XP_002199866  83 DRGSRHDFFSH-VKPINLGRKQLPYPALKGAMAFpADTEFQNIESIEE-RETTDEENSSKLPIGRRDFDILRCMLGRVYR 160 zebra finch
OCA40531     163 PCWQI 167 tropical clawed frog
NP_001182724 159 PCWQV 163 chicken
Q16048        82 SCWQV 86  human
XP_002199866 161 PCWQV 165 zebra finch
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