Conserved Protein Domain Family
MRVI1

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pfam05781: MRVI1 
MRVI1 protein
This family consists of mammalian MRVI1 proteins which are related to the lymphoid-restricted membrane protein (JAW1) and the IP3 receptor associated cGMP kinase substrates A and B (IRAGA and IRAGB). The function of MRVI1 is unknown although mutations in the Mrvi1 gene induces myeloid leukaemia by altering the expression of a gene important for myeloid cell growth and/or differentiation so it has been speculated that Mrvi1 is a tumor suppressor gene. IRAG is very similar in sequence to MRVI1 and is an essential NO/cGKI-dependent regulator of IP3-induced calcium release. Activation of cGKI decreases IP3-stimulated elevations in intracellular calcium, induces smooth muscle relaxation and contributes to the antiproliferative and pro-apoptotic effects of NO/cGMP. Jaw1 is a member of a class of proteins with COOH-terminal hydrophobic membrane anchors and is structurally similar to proteins involved in vesicle targeting and fusion. This suggests that the function and/or the structure of the ER in lymphocytes may be modified by lymphoid-restricted resident ER proteins.
Statistics
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PSSM-Id: 399060
Aligned: 8 rows
Threshold Bit Score: 652.34
Threshold Setting Gi: 75050786
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9N1F0        325 VESELGKPLAKTAKEGNPLPRGPTQGS----------------GGVAPQASQGKSTVGE-----PAGSKVGSKAELWPPT 383  cattle
Q12912         23 GEVKDGALDVKRQHKCPGPTSGPSPGTnlsgcirmnddpsmeeNGVERVCPESLLQSREysslpLPRHTSSTDGTITSSD 102  human
XP_005975241  856 EEIEDCALAVTERHRCPGPSAGPHPGTdlsgcirmnndlsmeeNGVEYLCSESQPQPREystlpSPGHTSSTESTVTSSD 935  chiru
XP_016154613  243 CENELGKSFLKKGKENDVPLRTHLPGP-----------------GIGNMDSKLKIPVPE-----MRDHKVPCKPEFKLCG 300  Collared flyc...
Q60664         10 QEPEDGALDVTRGCQCPLPTEDSILGQelldctrmnedqstdeNGAGHFYSESPSQLREyltqpSSEQTSSSESTVTSSE 89   house mouse
XP_013008589  594 gEIKDDALYVTRGQKCPGPTEGPEHRPdlsdcirmngdlsmeeNGVERLHSENLSQSREhlvlpSPEHASSPESTVTSSD 673  domestic guin...
XP_027708438  188 GEKDPGKQFLKKPKESDPLLKSHSQGP-----------------GSTPQGPQGKGPAWE-----PLNSKTPSKADLKPSG 245  common wombat
XP_023410612    1 ----------------------------------msddlsmeeNGVEHLNSENLPQSREyptlpLPGHTSSTDSTVTSSD 46   African savan...
Q9N1F0        384 SRPPLLRGVSWDSGPEEPGPRlqkvlaklplaEEEKRFTGKAGSKLAKAPGLKDFQIQVQpvrmqkltklreehiLLRNQ 463  cattle
Q12912        103 PGLEILNMASCDLDRNSLCKK-----------EEDTRSASPTIEAQGTSPAHDNIAFQDS---------------TSKDK 156  human
XP_005975241  936 SASEILHMASGDLDCKPLCEK-----------EEDKKSASAVTKIPGRSPAPENIELQGS---------------VTEEK 989  chiru
XP_016154613  301 LRPPLLRAVSWDS--LEPGQKektpl--klpcEEEKSFVGNKSSNQLKA--FKDLQIQVQpvrmqkltklreehiLMRNQ 374  Collared flyc...
Q60664         90 SGSDILHMASGDLDCKPLCEK-----------EEEARAASAMQGTSLAPAAYGDYT---S---------------VGVAK 140  house mouse
XP_013008589  674 AGSENLHMASDDLDCKSLCET-----------QQKAKSASTtmeiqgtsstyenia---------------cqdtvtkek 727  domestic guin...
XP_027708438  246 FRPPLQRGLSWDSSPMEPGSKdkvia-klasaEEEKHFPSKAGNKLPKSSGFKDFQIQVQpvrmqkltklreehiLMRSQ 324  common wombat
XP_023410612   47 ASSEILNMSSGDPACRSFCEK-----------EEDTRAASTMIETQGTSPAPDNIPLPGS---------------MSEDK 100  African savan...
Q9N1F0        464 NLVGLKLPELSEAAEQEKGhpselssaieeeESKGGLDVMPNISDVLLRKLRVHKSLPGSApplTEKEVENVFVQLSLAF 543  cattle
Q12912        157 TILNLEAKEEPETIEEHKK------------EHASGDSVVSPLPVTTVKSVNLRQSENTSA---NEKEVEAEFLRLSLGF 221  human
XP_005975241  990 SIMNLEAKKEPETIDEHRK------------ECAAGGAALSSLP---VKSVNFRQSDNTSA---NEKEVEAEFLRLSLGF 1051 chiru
XP_016154613  375 NLVGLKLPELSEAAEQEKGpsplps-pteegETKNSSDVMPSIPDVLLRKLRVHKSLPGSSpplTEKEVENVFVQLSLAF 453  Collared flyc...
Q60664        141 AASQLEAGEELRTTENGGK------------GSAPGETEISMPPKASVKLVNFQQSENTSA---NEKEVEAEFLRLSLGL 205  house mouse
XP_013008589  728 tvsnlEAKEVPKTTEEHRK------------ECAAGETEVSSPPVATGRSVNFRQSDNTSA---NEKEVEAEFLRLSLAF 792  domestic guin...
XP_027708438  325 NLVGLKLPDLSEAVEQERGhpselspgieeeESKSVCDVMPNISDVLLHKLRVHKALPGSApplTEKEVENVFVQLSLAF 404  common wombat
XP_023410612  101 AILHLEAKEEPETMEEHRK------------ECAAGDTAVSPLPVTTVKSVNFRQSDNISA---NEKEVEAEFLRLSLGF 165  African savan...
Q9N1F0        544 RNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLwhhCEH----RETYQKLLEDIAVLHRLAARLSSRAEMV 619  cattle
Q12912        222 KCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPL---CEDdnqaQEIIKKLEKSIKFLSQCAARVASRAEML 298  human
XP_005975241 1052 KCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTSL---CEDdsqaQEIIKKLEKSITFLSQCTTRVASRAEML 1128 chiru
XP_016154613  454 RNDSYTLESRIQQAERERNLTEENAEKELENFKAAITSSAHLwhhYEH----REAYQKLLEDIAVLRRLAARLSSRAEMV 529  Collared flyc...
Q60664        206 KCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPL---CEEdnqaQEIVKKLEKSIVLLSQCTARVASRAEML 282  house mouse
XP_013008589  793 KCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPL---CEEdnqaQEIIKKLESSITFLSQCTARVASRAEML 869  domestic guin...
XP_027708438  405 RNDSYTLESRISQAERERNLTEENTEKELNNFKASITSSASIwqpCEH----RETYEKLLEDVAVLHRLAARLSSRAEMV 480  common wombat
XP_023410612  166 KCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPL---CEDdsqaLEIIKKLEKGITFLSQCTVRMASRAEML 242  African savan...
Q9N1F0        620 GAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNsSRSCGP--SEDGVPRTARSMSLSlGKNMPRRRVSV 697  cattle
Q12912        299 GAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQN-ERSFNPleDDDDCQIKKRSASLN-SKPSSLRRVTI 376  human
XP_005975241 1129 GAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQN-ERSFNPleDEDDCQTKKRSSSVN-SKPSSLRRVTI 1206 chiru
XP_016154613  530 GAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNsSRSYGA--SEDGVPRSSRSMSLTvGKNMPRRRVSV 607  Collared flyc...
Q60664        283 GAINQESRVSRAVEVMIQHVENLKRMYAKEHAELEDLKQALLQN-DRSFNSlpDEDDCQIKKRSSSLN-SKPSSLRRVTI 360  house mouse
XP_013008589  870 GAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQN-ERSFNPleDEDDCQIKKRSASLN-SKPSSLRRVTI 947  domestic guin...
XP_027708438  481 GAVRQEKRMSKAAEVMMQYVENLKRTYEKDHAELMEFKKLANQNsSRSYGP--SEDGVPRTTRSMSLSlGKNMPRRRVSV 558  common wombat
XP_023410612  243 GAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQN-ERSFNSlgDEDDCQIKKRSASLN-SKPSSLRRVSI 320  African savan...
Q9N1F0        698 AVVPKfnilNLpGQSPSSSPIPSLPALSE-SSNGKgnppvssalpaLLENGKTNGDPDCE----ASASVPTPSCLEGISQ 772  cattle
Q12912        377 ASLPR----NI-GNAGMVAGMENNDRFSRrSSSWR-----------ILGSKQSEHRPSLP----RFISTYSWADAEEEKC 436  human
XP_005975241 1207 ASLPR----NI-GNAGMLAGMENNERFSRrSSSWR-----------ILGSKQSEHRPSLH----RFISTYSWADAEEEKC 1266 chiru
XP_016154613  608 AVVPKfnslNIpGQSPTASPIPSMPSLSEsPSNGRsnltstpalpaLLENGKSNGEPDCE----TSTSVLSQSGLEEISP 683  Collared flyc...
Q60664        361 ASLPR----NL-GNVGLVSGMENNDRFSRrSSSWR-----------ILGTKQGEHRPSLH----RFISTYSWADAEDERS 420  house mouse
XP_013008589  948 ASLPR----NI-GNAGMAAAME-NDRFSRrSSSWR-----------ALGTKQSEHRPSLH----RFISTYSWPDAEDEKC 1006 domestic guin...
XP_027708438  559 AVVPKfnalNIpGQSPNTSPIPSLPALAE-SPNGKgnssaslappaLLENEKSNGDPDCEgpapSVSPALTQSALEEISQ 637  common wombat
XP_023410612  321 ASLPR----NI-GNVGTMAGMENNDRLSRrSSSWR-----------ILGSKQSEHRPSLH----RFISTYSWTDAEEEKC 380  African savan...
Q9N1F0        773 EAKARMEEEAYNkgyQEGLKKTKElQGLREEEEEQKSESpeepeevaeteeeekeqRSSKLEELVHFLQVMYPKLCQHWQ 852  cattle
Q12912        437 ELKTKDDSEPSG---EETVERTRK-PSLSEKKNNPSKWD-----------------VSSVYDTIASWATNLKSSIRKANK 495  human
XP_005975241 1267 ELKTKDDLEPPE---EETVEKTRK-PSLSEKKTNPSKWN-----------------VSSIYDTLASWATNLKTSIREANK 1325 chiru
XP_016154613  684 ETKAKIEEEAYNkgyQEALKKTKElQQLKEEDEETPKEShdeheese-nedeiknlKSSRLEVIVNYLYILYPKLCKHWN 762  Collared flyc...
Q60664        421 DVKARDAPEPQG---EEAVERTRK-PSLSERRSSTLAWD-----------------RGTICSSVASWVTHLQASFRRANR 479  house mouse
XP_013008589 1007 DPKTKDDSESPG---EEIVERTRK-TSLSERKNNPSRWG-----------------ISSIPDTLASWVTHLGTSVRKANK 1065 domestic guin...
XP_027708438  638 EVKAKIEEEAYNkgyQEGLKKTKElQELKEDE--EEKTNenldgper--edeekelKSSKFEALIHFLQILYPKLCQHWN 713  common wombat
XP_023410612  381 EVKTKDDSEPPG---EEIVEQTRK-PSLSEKRNNPSKWD-----------------VSSIYDTIASWAANLKTSFGKANK 439  African savan...
Q9N1F0        853 VIWMMAAAMLVLTVVLGLYGS--HNSCVEQADGSLGKSTCSAAQRdSWWSSGLQHEQPTEQ 911  cattle
Q12912        496 ALWLSIAFIVLFAALMSFLTGqlFQKSVDAAPTQQEDSWTSLEHI-LWPFTRLRHNGPPPV 555  human
XP_005975241 1326 MLWLSVAFIVLFAALMSFFTGrfFQKSVDAAPTEDADPWMSLEHI-LWPFTRLRHNGPPPV 1385 chiru
XP_016154613  763 VVWLVVAAIVIFAVVLGIYHS--YNSCDEKSEAPEGKASCSAAHQySWWNSGFRQEQRTE- 820  Collared flycatcher
Q60664        480 ALWLTGLIIILIAALMSFLTGqlFQTAVEAAPTQEGDSWLSLEHI-LWPFTRLGHDGPPPV 539  house mouse
XP_013008589 1066 TLWLSVALIVLFAALMSLLAGrfFQKSVEAAPTQEGDSWISLEHI-LWPFTGLQHNGPPPV 1125 domestic guinea pig
XP_027708438  714 VIWMVAAAILVLTVVLGLYNS--YHSCAELSEGASGKATCSASQRdSWWNSGLQQEQPTEQ 772  common wombat
XP_023410612  440 ALWISVAFIVLFAALMSFLTGlfFQKPVDAAPIRNGDSWMSLEHA-LWPFTKLQHNGPPPV 499  African savanna elephant
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