2JQ3


Conserved Protein Domain Family
Apo-CIII

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pfam05778: Apo-CIII 
Apolipoprotein CIII (Apo-CIII)
This family consists of several mammalian apolipoprotein CIII (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue glycoprotein. It is synthesized in the intestine and liver as part of the very low density lipoprotein (VLDL) and the high density lipoprotein (HDL) particles. Owing to its positive correlation with plasma triglyceride (Tg) levels, Apo-CIII is suggested to play a role in Tg metabolism and is therefore of interest regarding atherosclerosis. However, unlike other apolipoproteins such as Apo-AI, Apo E or CII for which many naturally occurring mutations are known, the structure-function relationships of apo C-III remains a subject of debate. One possibility is that apo C-III inhibits lipoprotein lipase (LPL) activity, as shown by in vitro experiments. Another suggestion, is that elevated levels of Apo-CIII displace other apolipoproteins at the lipoprotein surface, modifying their clearance from plasma.
Statistics
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PSSM-Id: 399059
Aligned: 17 rows
Threshold Bit Score: 92.9598
Threshold Setting Gi: 1335179301
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2JQ3_A         3 AEDASLLS----FMQGYMKHATKTAKDALS-SVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFS--EFWDLD 68 
G5BQH4        23 TEDASLLGymqdYMQGYMEHASKTAQDALT-RVQDSQMAQQARGWMSDSLSSLQDYWSSFKGKWSgfGFWDAT 94  naked mole-rat
XP_005328348  23 AEDASLLS----FMQGYMDRATRTAQDALT-KVQDSEMAQRARGWMNGGINSLKDYWSSFTDKFS--GFWEST 88  thirteen-lined ground ...
Q9Z2R5        23 IQESSLLG----VMKDYMQQASKTANEMLT-KVQESQVAENAREWMTESLDSMKGYWTSLIGRLS--GFLDST 88  domestic guinea pig
P33622        23 VEGSLLLG----SVQGYMEQASKTVQDALS-SVQESDIAVVARGWMDNHFRFLKGYWSKFTDKFT--GFWDSN 88  house mouse
P27917        23 AEDTSLLD----KMQDYVKQATRTAQDALT-SVKESEVAQQARGWVTDSISSLKDYWSTFKGKFT--DFWDYT 88  pig
P19035        23 AEEGSLLD----KMQGYVKEATKTAKDALS-SVQESQVAQQARDWMTESFSSLKDYWSSFKGKFT--DFWESA 88  cattle
NP_001003369  23 EEDPSLLG----LMQGYMQHATKTAQDTLT-SVQESQVAQRARGWMTDSFSSLKDYWSTFKGKFT--GFWDSA 88  dog
XP_023600078  23 ADEDSLLK----LMQDYVQQA----QEALTsSVKDLSMAQEASKWMSNGFNSLKDYWSSLTVPLS--NLWPLA 85  little brown bat
XP_023355192  57 EEEETILN----RVHDYMQQAARQAQEALT-TVQESQMAQQAKGWMADSFSSLHEYWSTWADKLS--VLWDTA 122 Tasmanian devil
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