2DAX,7E2K,2DAY


Conserved Protein Domain Family
RWD
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pfam05773: RWD 
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RWD domain
This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.
Links
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Statistics
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PSSM-Id: 399058
Aligned: 114 rows
Threshold Bit Score: 41.9257
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2DAX_A        11 EAQLAELDLLASMFPGENelivndqlavaelkDCIEk--KTMEGrSSKVYFTINMNLDVSD--------------EKMAM 74  human
Q4CY49       193 AILENELETMQSLFDESF--------------LGVKqidEKEFE-GREMYFSFSSGSG--------------------KR 237 Trypanosoma cruzi
Q4CVK5       249 AACEEEIGLLTSMYGEEC--------------VQRN----KTPV----VFLPLLLDGVSDEas-----------dMSLSA 295 Trypanosoma cruzi
Q4D6B4         5 DDNAEEVELLLSISPEVV--------------CRDP---THSST----LVFLLPFR------------------------ 39  Trypanosoma cruzi
XP_008004661  10 QLQLLEMEMLFSMFPNQGe-------------VKLE---DVNAL----TNIKRYLEGTREAlppkiefvitlqieEPKVK 69 
Q4CLS7        26 DVIEDEIEFLKQNYDGIE--------------VVKLe--GFYPK----VLLTLEAESNP------------------RHR 67  Trypanosoma cruzi
Q4QCY6         6 EMQEMEMEMVQGMY-DTY--------------ERLS---DDPPS----YCVSLAATQDE------------------PPQ 45  Leishmania major
Q4DGH6         5 EMQSMEMDTVQSMYDSYEl-------------ISVD---P--------PTYSVLLTATAD----------------DPPE 44  Trypanosoma cruzi
Q8T6F6        44 DLQDNEVQTLHYLGLPYV--------------VLAR---RPRLR----VKVPLSTINYEIGq-------------WVGIA 89  Drosophila pseu...
Q8MZ95        30 DLQENEVRTMHYLGLAYV--------------VLSR---RPNLQ----LKVPLSTQNYEDGasvg-------ageRGGYA 81  fruit fly

2DAX_A        75 FSLACILPFK-YP-AVLP-EITVRSVL------------------LSRSQQTQLNTDLTAFLQKHc-HGDVCILNATEWV 132 human
Q4CY49       238 VVVCVRVPNQ-YP-ADPP-LILVQPCGnqvgtlpilgvfhadtkeLPAALRRSILDAAVETINGF--AGEGCLVALMSSL 312 Trypanosoma cruzi
Q4CVK5       296 LRICMTLPRR-YP-AELP-KLDVVGGPaah------------hvfFERWKLQLITKTLAYLRDDLg-VGNAMLLPAMMFA 359 Trypanosoma cruzi
Q4D6B4        40 FVLHVTLPPRgYPdVSRP-SLFVAAGP-------------------NAHLVNQFSSQLNKALREEvpLGGPMLLHIFTLA 99  Trypanosoma cruzi
XP_008004661  70 IDLQVTMPHS-YP-YVAL-QLFGRSSE------------------LDRHQQLLLNKGLTSYIGTFd-PGELCVCAAIQWL 127
Q4CLS7        68 VVLEVAIVAG-YP-FVAP-RVRLRIPEgvtpg---------sigaLDESGAHQIQADIREAISPCllVGAPCIMQIISVV 135 Trypanosoma cruzi
Q4QCY6        46 LRVIITYPTEeYP-ESAPcVVAVECISk-----------------ARRIQVGAITKQVASICEEN--IGMHSVVLALQQV 105 Leishmania major
Q4DGH6        45 LRVTIVYDSEgYPeTAAP-TVRLEHIAk-----------------HRRMQTAALAKEIEDLCAEQ--IGMHSVISVLQKA 104 Trypanosoma cruzi
Q8T6F6        90 MQLLFTCPSN-YP-MQRP-LVEIVEKRn-----------------VSIALEWALHEEIVQSLDQH--IGLQMIAPVTIRL 147 Drosophila pseu...
Q8MZ95        82 LQLLFTCAAN-YP-LARP-LVEIVEKRn-----------------VSDAFEQVLRKEIDLILEEH--LGLQMIVPVVTRL 139 fruit fly

2DAX_A       133 REHA 136 human
Q4CY49       313 HGVI 316 Trypanosoma cruzi
Q4CVK5       360 GEQA 363 Trypanosoma cruzi
Q4D6B4       100 QDIA 103 Trypanosoma cruzi
XP_008004661 128 QDNS 131
Q4CLS7       136 ERVL 139 Trypanosoma cruzi
Q4QCY6       106 QDFL 109 Leishmania major
Q4DGH6       105 QEYL 108 Trypanosoma cruzi
Q8T6F6       148 QTLL 151 Drosophila pseudoobscura
Q8MZ95       140 QITL 143 fruit fly
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