3R3Q


Conserved Protein Domain Family
UEV

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pfam05743: UEV 
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UEV domain
This family includes the eukaryotic tumor susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumor suppressor for sporadic forms of breast cancer. This family is related to the ubiquitin conjugating enzymes.
Statistics
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PSSM-Id: 399041
Aligned: 21 rows
Threshold Bit Score: 111.968
Threshold Setting Gi: 74585176
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3R3Q_A    33 TFHDSLALLDNFH----SLRPRTRVFTH-SDGTPQLLLSIYGTISTGEDgsspHSIPVIMWVPSMYPV------KPPFIS 101 baker's yeast
Q59WF8    24 VYAHVFQFLQLHLkknlNFKIRTQIYTSsGSGEPNLLINLFGTIQINEQ----IGTPIEIWVPFAYPYvdyenkGAPIVY 99  Candida albicans
Q75EU1    32 TFHDVVIALRAYK----KLRPRTRVFTD-EAGRSKLLLCLYGKV---------GNVDVLIWIPFEYPN------VAPHAY 91  Eremothecium gossypii
Q6FS29    27 VFHDAVQTLTEFK----NLRPRTRVFTD-EDGSPRLLLCLYGGIPIEQG----LDVPVLIWIPESYPI------AKPLLF 91  [Candida] glabrata
Q5KKQ1    24 ITQEVLYVLQQRR----TLAVKTDAFTF-DSGHTALLLLLHGTLPVTYRga-iYQIPIHLWVPHEYPR------APPLIF 91  Cryptococcus neofor...
Q5BAA9    33 TYYDVANVLAKFP----TLAPETAVYTY-ENGFSALLLQLSGTLPVTFRgt-vYKFPIALWIPNTYPR------EPPIVY 100 Aspergillus nidulans
CAF90282  24 TQADLRRVRSRFS----DLRLHVDYYRF-PNKEKKQLVYLAGTVPVLYEgs-cYNIPVSIWLHQTHPV------SHPRCY 91  spotted green puffe...
Q6ESB7    45 IRNHLVALADAFP----SLHPKAALFTH-NDGRAAHLLQADGTIPIHHAga-sYNLPAVLWLPEPYPR------SPPLVF 112 Japanese rice
Q9LHG8    37 IRQHLLNLISSYP----SLEPKTASFMH-NDGRSVNLLQADGTIPMPFHgv-tYNIPVIIWLLESYPR------HPPCVY 104 thale cress
Q4UHS4    19 LMCDINGLFGKYH----NFSCSM------STSFDCHRLNISGTVPYTFSgf-tLNAPLLIQVFSDYPF------SCPSFF 81  Theileria annulata
3R3Q_A   102 INLENFDmntissSLPIQE-YIDSNGWI-ALPILHAWDP--AAMN-----LIMVVQeLMSllhePPQDQA 162 baker's yeast
Q59WF8   100 IVPDHSKg----wYLKPNN-NVDTQGMF-YHPYLTRWHRecLRSNpdslnMFSLVE-LANviyrSVTTDS 162 Candida albicans
Q75EU1    92 IDLEANKg----rSIIVNQ-RLDGDGLF-YLPILGHWHP--QNCN-----VVKLVQdLEQ----AIMAQE 144 Eremothecium gossypii
Q6FS29    92 IDLELLDkd---lQLATNE-SVEPDGRV-HTRLLRQWNP--QSAN-----LFNVIQdLAD----MCNAIA 145 [Candida] glabrata
Q5KKQ1    92 VMPTKDM------GVRKSR-EVEPSGRV-REEVVEGWWRawEVKN-----LDMLLKhLAD----VFSAAP 144 Cryptococcus neoformans
Q5BAA9   101 VKPTQDM------VVRVGQ-HVTLEGRV-YHHYLAHWGGawERSS-----LLDLLSiLQD----VFAKEP 153 Aspergillus nidulans
CAF90282  92 VCPSVSM------VINPACsCADAAGLL-HLDGLRNWTG--GASS-----LSLLVSeMVQ----VFQKDM 143 spotted green pufferfish
Q6ESB7   113 LSPTRDM------VIKPHHpLVDRSGLVaNAPYLRSWVF--PSSN-----LVDLVRsLSH----LFGLDP 165 Japanese rice
Q9LHG8   105 VNPTADM------IIKRPHaHVTPSGLV-SLPYLQNWVY--PSSN-----LVDLVSdLSA----AFARDP 156 thale cress
Q4UHS4    82 VPSRNT-------KIVKNHpNVDLRGNV-TLKYLDEWNH---TSK-----LVQAVDhLCY----AFSKIS 131 Theileria annulata
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