Conserved Protein Domain Family
TANGO2

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pfam05742: TANGO2 
Transport and Golgi organisation 2
In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation. In plants this family includes Solanum habrochaites Cwp, which is involved in water permeability in the cuticles of fruit. Mouse Tango2 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.
Statistics
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PSSM-Id: 399040
Aligned: 107 rows
Threshold Bit Score: 147.778
Threshold Setting Gi: 332191883
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007297583       1 MCIVIAT--TAHP-AYALILLDNRDEFITRPTSRPHWWt---S-HHQHILSSRDLQRaEQGTWLGITRTG-NLAVLTN-Y 71  Marssonina ...
NP_173496          1 MGIVAFQwgEGE---NILTLLQNRENWQSRSIGKAAW-----EwDESQVLSGRCAE--TDGTWLGISIRG-RVAFLVEag 69  thale cress
JCVI:AT1G20680.2   1 MGIVAFEwaEGK--TNQLTLLMNRDNWENRVISGASWS------RNGQILSGRCKA--NNGTWFGITKGG-RVAFLVN-- 67  thale cress
XP_009101954       1 MCIAVFLw-QSHP-LYPFLLFLNRDEYLNRATEALRWW------QDGETLGGRDLVG--GGTWLGCTRHG-RIAFLTN-F 68  field mustard
EFH45100           1 MCIAVFLw-QSHP-LYPFLLFLNRDEYHNRATEALRWW------EDGETVGGRDLVG--GGTWLGCTRHG-RLAFLTN-F 68  Arabidopsis...
XP_006361539       1 MCIAVFIw-KAHP-LYPFLLILNRDEYHNRPTKPLSWW------EDSDILGGRDEVA--GGTWLACTRTG-RLAFLTN-V 68  potato
XP_003631559       1 MCIAVFLw-QAHP-IYPFLLLLNRDEYHNRPTEALAWW------QGGEILGGRDGLA--GGTWLACSRDG-RLAFLTN-V 68  wine grape
ERN17208           1 MCIATWAw-RAHP-LYPLILFLNRDEYYNRPTEPVSWW------GEPEIIGGKDCLA--GGTWLACSKHG-RLAFLTN-F 68  Amborella t...
KQJ84065           1 MCIAAWTw-QSHP-AYGLLLLFNRDEFLSRPTRPAGWWaaagE-EGEEILGGKDELG--GGTWLGCTKGG-KLAFLTN-V 73  stiff brome
XP_001010458       1 MCITFFFidRTPdaKIKFVMVHNREEDFARPTLQLGQF----E-EDTNIFGGRDER--EKGTWLGFNAKTqNLAFLTNrF 73  Tetrahymena...
XP_007297583      72 -------RETDt--SDAQhPVvgaRSR-GGM-----VTAWLtaAVD--ES----------------TDAF-VRrlmagdG 117 Marssonina ...
NP_173496         70 -----------------------pVNRdRIIgaecrTLDFLksNLSpeDF----------------ADSL-AL------D 103 thale cress
JCVI:AT1G20680.2  68 --------------TSLLlDRvksYSGsELY-----PVRFLegNMSpeQF----------------ANEVkVHe----kE 108 thale cress
XP_009101954      69 -------RETS--------SIpdaKSR-GDL-----PLRFLqsHKSpaEF----------------AQEI-EK------E 104 field mustard
EFH45100          69 -------REAS--------SFpdaKSR-GDL-----PIRYLqsRKSpaEF----------------AEEI-QD------E 104 Arabidopsis...
XP_006361539      69 -------REIN--------SNshtKSR-GDL-----PLRFLksVKSphDF----------------SEQL-LK------E 104 potato
XP_003631559      69 -------REVH--------PIpeaKSR-GDL-----IVRFLesKKNpmEF----------------AEEV-MK------E 104 wine grape
ERN17208          69 -------REVD--------VTpdaKTR-GEL-----PLRFLqsEKNpiEF----------------AEEV-VK------E 104 Amborella t...
KQJ84065          74 -------REPS--------PRagaRSR-GEL-----PVRFLqgRLGplEY----------------ATEI-AK------E 109 stiff brome
XP_001010458      74 swsifkdRMISkinVFSKaSEqktISR-GKL-----IQEFIs-----tDFferyslqddenstynyAKTI-FQ------N 135 Tetrahymena...
XP_007297583     118 VKGVGG--FSLLCGKLRkrrrgregeseresesekemekelePLAIVSNRC-------------EDpENVpWFaerrgGV 182 Marssonina ...
NP_173496        104 SGRNTGiaYHLIVADIVs-----------------------nSMFYIYKPSlsedgmvytepvgP-------------GV 147 thale cress
JCVI:AT1G20680.2 109 TNERHA--YSLVVADMTs-----------------------sSMVHILKPSdtksdvv--------------ietvpfGV 149 thale cress
XP_009101954     105 ASLYNG--FNLVVAHVFs-----------------------kSMFYVTNRPlshgdkqqqqqqqQLvTLV-SP-----GI 153 field mustard
EFH45100         105 ISLYNG--FNLVVAHVLs-----------------------kSMIYITNRPphg---------hkLaTQV-SP-----GI 144 Arabidopsis...
XP_006361539     105 VGEYNG--FNLIVADLCs-----------------------mTMLYITNRPkh---------tgMSvTEV-SP-----GI 144 potato
XP_003631559     105 ADKYNG--FNLIIADLCs-----------------------kTMIYITNRPre---------anVSvVEV-SP-----GI 144 wine grape
ERN17208         105 GHHYNG--FNLIMADLWl-----------------------eSMVYVSNRPkd---------epATfKEV-SP-----GL 144 Amborella t...
KQJ84065         110 ADQYNG--FNLILADVHs-----------------------gNMVYISNKPsg----------aPVvQTV-SP-----GS 148 stiff brome
XP_001010458     136 KNRFMP--FNLLVANLKh-----------------------mEFVFQGNYDkfppv------------------slrdGY 172 Tetrahymena...
XP_007297583     183 YALSN-NSYdd-------pdVWPKVKMGREKVIQAVDALLes-------gGG-EEE--LV--ERLWE----VLDADTl-- 236 Marssonina ...
NP_173496        148 HTLSS-AGLdsevghrdlrlK--------RYFSERINREl-------------PEPisGLaeEVMYDtveaINGDP---- 201 thale cress
JCVI:AT1G20680.2 150 HTLSSyEGLdstdsardlllR--------RLFTQMVGNLG----------NVqQRQmeEIagRFMYDa------------ 199 thale cress
XP_009101954     154 HVLSN-ANLd---------sPWPKCLRLRDGFNQLLTQH------------PrGEF--PV--KTMVEe---VMTDTVk-- 202 field mustard
EFH45100         145 HVLSN-ANLd---------sPWPKCLRLRECFQQLLAEN------------GsREF--PV--KTMVEe---VMTNTVk-- 193 Arabidopsis...
XP_006361539     145 HVLSN-ATLd---------sPWPKSQRLEYSFKQLLDEY------------GeSEI--PI--GKAAEr---IMRDLAk-- 193 potato
XP_003631559     145 HVLSN-ASLd---------sPWPKARRLGHNFKELLDKY------------GeGEI--PT--EEMVEk---LMKNTIk-- 193 wine grape
ERN17208         145 HVLSN-AKLd---------tPWPKATRLILSFEKLLKEY------------DrEEI--PE--KEMLHk---LMLDTMk-- 193 Amborella t...
KQJ84065         149 HVLSN-AAId---------sPWPKALRLGQSFNRFLATH------------DsVEV--PL--EQMVEe---LMMDTVk-- 197 stiff brome
XP_001010458     173 HTFCNfSSFe---------aPIQKQVVGLNRFKELVQQTIsnlkdnnaekIQkENEngLI--QNIHD----IMENEQyqf 237 Tetrahymena...
XP_007297583     237 PPqkegetfEDYI---------FELRKSIF-----IHpIGsaatppllkpdvvaaadpsiangpslakgdlelkdeerpd 302 Marssonina ...
NP_173496        202 -------------------------LSSIFvvdtlIEn------------------------------------------ 214 thale cress
JCVI:AT1G20680.2 200 ----------------------QAGRDAVFyhsrdehp------------------------------------------ 215 thale cress
XP_009101954     203 DQ-------Qphvf----ppetQYHLSSIF-----VDiPTpa-------------------------------------- 228 field mustard
EFH45100         194 DE-------ETELphvf-tpetEYHLSSIF-----VDmQRpt-------------------------------------- 222 Arabidopsis...
XP_006361539     194 ED-------SN-Lpgiy-specEYQLSSIF-----VDtEMsm-------------------------------------- 221 potato
XP_003631559     194 DD-------EIVLpriy-pperEHQLSSIF-----VDtDTpl-------------------------------------- 222 wine grape
ERN17208         194 AD-------RENLpntgcdpdwDYNLSSIF-----VEtDSek-------------------------------------- 223 Amborella t...
KQJ84065         198 AD-------RSEVpdtgvdpdwEYQLSSIF-----IDtEKgq-------------------------------------- 227 stiff brome
XP_001010458     238 TFsllp----------------mwneSKIF-----IKpYY---------------------------------------- 256 Tetrahymena...
XP_007297583     303 pvtaapmtgIY------GTQRQTIILVDWE------GKVTFRERSLWD 338 Marssonina brunnea f. sp. 'multigermtubi' M...
NP_173496        215 --------eHY------GTRCTTALVVRRT------MQVRFFERYRAR 242 thale cress
JCVI:AT1G20680.2 216 --ngklgtqRF------GTTSTTALVVKRT------REVMLFEKYMEQ 249 thale cress
XP_009101954     229 --------gRY------GTRSISALTIKSH------GQVCFYERHLEP 256 field mustard
EFH45100         223 --------gRY------GTRSISAISIKSHgdgdgdGEVCFYERHLEE 256 Arabidopsis lyrata subsp. lyrata
XP_006361539     222 --------gRF------GTRSTSSLAVRSS------GDATFYEVYLEK 249 potato
XP_003631559     223 --------gRY------GTRSTSSVCVRAS------GEVNFYEKHLEN 250 wine grape
ERN17208         224 --------gCY------GTRSMVALSIRAS------GEVSFYERYRDN 251 Amborella trichopoda
KQJ84065         228 --------aRY------GTRSMVAIAVKLD------GEVTFYERSLAS 255 stiff brome
XP_001010458     257 ---------SYfsrhyrGTRTSTVLILNDK------NKLSISENTYSQ 289 Tetrahymena thermophila SB210
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