5KL8


Conserved Protein Domain Family
zf-nanos

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pfam05741: zf-nanos 
Nanos RNA binding domain
This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.
Statistics
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PSSM-Id: 399039
Aligned: 72 rows
Threshold Bit Score: 61.4143
Threshold Setting Gi: 341884962
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5KL8_B         32 CVFCENNN--------------EPEAVINSHSVRDnFN-------RVLCPKLRTYVCPICGASGDSAHTIKYCP 84 
PDM83437      773 CVYCKGTLk-------------LSEEEYSSHTLHDpSRprcgperRVTCPRLRETGCQYCGLKGDLAHDQFFCE 833 Pristionchus pacificus
1_pfamImport    1 CYHCAYYN--------------KPTEEISSHNIRKpNG-------DLWCEDLQKQKCQHCEATGEKGHHHLICP 53 
EFO91655      287 CFRCAYYD--------------MSKEEIASHNIRKeNG-------DLWCEHMKKIACVHCDAIGEKGHHPLVCP 339 Caenorhabditis remanei
EGT41018      119 CSFCFGTAtqragemgerlperDDWGTWSTHSCKE-RG-------IVTCPFLWQVTCPICGATGAAAHTRAEHV 184 Caenorhabditis brenneri
EGT48749      113 CSFCYGTAaqmareqgqpvpdkDDYGPWSSHSCKM-NG-------HVSCPFLWQVVCPLCGATGPVAHTRAEHL 178 Caenorhabditis brenneri
12_pfamImport   1 CSFCYGTYvtfarlsgnpilskDDSGPWSDHQCKT-NG-------IVSCPVLRRNKCTVCGATGDYAHTSKYHH 66 
8_pfamImport    1 CSFCYGLAakkaeeagepiadrDDDGPWSNHQLKS-DG-------AVSCPVLRAVVCNICGATGETAHTTVYHS 66 
EGT48747      112 CSFCYKVAaqwaaeqevqvpskDDYGYWSSHSLMGrYG-------VVVCPVLRRVVCGHCGATGDHAHTTRFHE 178 Caenorhabditis brenneri
EGT40897       90 CSFCWKRAarwaredgvpvpskNARGSWSTHSLKG-PGpn----rVVTCPVLRQVVCGHCGATGDHAHTTHHHE 158 Caenorhabditis brenneri
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