2A1X,2FCV,3OBZ,4XAA,5EPA,5EQU


Conserved Protein Domain Family
PhyH

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pfam05721: PhyH 
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Phytanoyl-CoA dioxygenase (PhyH)
This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.
Statistics
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PSSM-Id: 399029
Aligned: 39 rows
Threshold Bit Score: 100.992
Threshold Setting Gi: 81505735
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2A1X_A  31 YEENGFLVIKN----LVPDad-iQRFRNEFEKIc-RKEVKPLGLTVMRDVTISKSEYAPSek-mITKVQDFQEDkel--- 100 human
W7LKX6  34 WEEDGAIVIKG----LLTSaq-vEQLNQEMGPIl-QKVAIGGHASDVRLQNFHGMKTKRAgd-lTNNSAVFRDH------ 100 Fusarium verticillioi...
P9WI89  14 IDEFGYTVVED----VLDAds-vAAYLADTRRLe-RELPTVIANSTTVVKGLARPGHVPV--------DRVDHDwvridn 79  Mycobacterium tubercu...
P9WI91  19 LNCVGYAVVED----VLDEas-lAATRDRMYRVq-ERILTEIGKERLARAGELGVLRLMMky-dPHFFTFLEIP------ 85  Mycobacterium tubercu...
Q9X5S6  16 LVEAGYCLIEC----PLPAav-fEKLRGRLLEV--AEQERENGSAFLYDGGNQRVFSLLNk--gEEFEQNVQDP------ 80  Streptomyces lavendulae
Q9XZX7  45 GCLYGTLPDVDeyrqFVVPlqvlQQYHQLGYAKlpRPVLDPPQVDILADEVNQLANNVEHhpksEHLYATSLADltg--- 121 Leishmania major
Q8PGL9  37 LQEHGYAHLPG----VLSAke-cDAICADFMRYv-ARNRMEADKHVLGTGRHSRLTNMHLv--sNRARAAIAKP------ 102 Xanthomonas citri
Q92PC6  55 ARLAGDCATQDgrrsVLAEi--cEALATGPGVAvfKRAFTDTRVIDEASGIFNEIIEEQHrt-nSGGGDHFAKPga---- 127 Sinorhizobium meliloti
Q9KZG7  48 VYDAGQLRDDA----GTAAel-vHALADGPGLVvlKGAFPDPAVVDRATAVFDALIAEQRas-gAAAGDHFAAPga---- 117 Streptomyces coelicolor
Q8Y0R0   5 FDTDGYAIVPG----VLPAkt-cTALTDRLHAq--GAGTRELLAQPWCAALADTLRTHPA-----------LAP------ 60  Ralstonia solanacearum
2A1X_A 101 ---fryCTLPEILKYVECFTGPNI-------------MAMHTML----INKPPDsGKKTsrhPLHQDLHYFPfr------ 154 human
W7LKX6 101 -------LLDNDFIHAVSQRCFAYr------------GKMGPDAywlgSASTIHvGPGQkpqTLHRDLGSYPifwml--- 158 Fusarium verticillioi...
P9WI89  80 lllhgtRYEALPVHPKLLPVIEGV-------------L-GRDCLlswcMTSNQLpGAVAq--RLHCDDEMYPlpr----- 138 Mycobacterium tubercu...
P9WI91  86 -------EVLSIVDRVLSETAILH-------------L-QNGFIl---PSFPPFsTPDVfqnAFHQDFPRVLsg------ 135 Mycobacterium tubercu...
Q9X5S6  81 -------TVMLLMEEILG---------------------FGFLLs---STHANIaGPGGsrmHLHADQTFARppw----- 124 Streptomyces lavendulae
Q9XZX7 122 ---gplFYCQGQWRCAWGMHDLVYlptltvaasqalgNRLVRLWydeaFMKEARtGPCV---PWQQNYVRWQht------ 189 Leishmania major
Q8PGL9 103 -------VVMKALDAFFGDRAFVA---------------TSLFF------------EQSseqALHRDTPFFHtr------ 142 Xanthomonas citri
Q92PC6 128 ----ndRIWNSLEKHCLKNPENFAayygnaiialvseAWLGPNYqmtaQVNRVNpGGASq--SPHRDYHLGFqtsavieq 201 Sinorhizobium meliloti
Q9KZG7 118 ----ndRVWNALEKAALRDAEAFAdyyandalalvarAWLGPGYqvtsQINVVNpGGAAq--TVHRDYHLGFlsdraaaa 191 Streptomyces coelicolor
Q8Y0R0  61 --------WLPAAHAAIQCTGFDKsa---------gqNWLVPIHqdlsIPVAERvGDSAl-qGWSEREGRLYvqpp---- 118 Ralstonia solanacearum
2A1X_A 155 ----psDLIVC----AWTAMEHISRNNGCLVVLPGTHKGSLKP-------HDYPKWeggvnkmfh----giqdyeenKAR 215 human
W7LKX6 159 -gpqgpESQIN----FLVATTDFTEANGATRIIPGSHKWEFN---------QHGDR---------------------DMT 203 Fusarium verticillioi...
P9WI89 139 ---phqPLLCN----ALIALCDFTADNGATQVVPGSHRWPERPs------PPYPEG------------------------ 181 Mycobacterium tubercu...
P9WI91 136 -----yIASVN----IMFAIDPFTRDTGATLVVPGSHQRIEKPd------HTYLAR----------------------NA 178 Mycobacterium tubercu...
Q9X5S6 125 ---ppyPLVAN----SMWMLDDFTEDNGATRLVPGSHLLGRQP--------DYDRGeg------------------nTET 171 Streptomyces lavendulae
Q9XZX7 190 ----tpVNHVS----IMIALDTLNKDRGAPCLIPGSHRWREGQllppvpyDPTQSEtqqlntiwditnddeqemladTPP 261 Leishmania major
Q8PGL9 143 ----pnNIFAG----IWFALEDVHAEAGPLKYYPGGHLIEIESiqatgaeQLGEAFnhyigrva-----eevhkrgiKPE 209 Xanthomonas citri
Q92PC6 202 ypahvhRLSPVltlqGAVAHCDMPVESGPTLFLPYSQTYLPGYlalkrpeFRTYFE---------------------ENH 260 Sinorhizobium meliloti
Q9KZG7 192 ypahvhRLSPVltlqGAVAHCDMPVESGPTMYLPHSQKYEPGYlawrlpeFRAYFE---------------------ARH 250 Streptomyces coelicolor
Q8Y0R0 119 --rqvlEALIA----VRLHLDDCGATAGPLRVVPGSHRQ--Grl----tqAQMLAEre------------------rRGE 168 Ralstonia solanacearum
2A1X_A 216 VHLVMEKGDTVFFHPLLIHGSGQNKTQG--FRKA 247 human
W7LKX6 204 IPAEMKAGDCLLISGKVIHGTGGNKTDQ--ERGC 235 Fusarium verticillioides 7600
P9WI89 182 KPVEINAGDALIWNGSLWHTAAANRTDA--PRPA 213 Mycobacterium tuberculosis H37Rv
P9WI91 179 VPVQCAAGSLFVFDSTLWHAAGRNTSGK--DRLA 210 Mycobacterium tuberculosis H37Rv
Q9X5S6 172 VAVCAPAGSVMVFDGRLWHQTGANTTDR--PRHG 203 Streptomyces lavendulae
Q9XZX7 262 ATVDLRRGEALLIHPKTLFATHGNRSLD--AARC 293 Leishmania major
Q8PGL9 210 IAL-IKKGDCFIWHPELPHGGTPILSAGm-TRKS 241 Xanthomonas citri
Q92PC6 261 VQLPLEKGDVVFFNPALFHAAGSNRSAG--IKRV 292 Sinorhizobium meliloti
Q9KZG7 251 VQLPLAKGDAVFFSPALFHAAGTNRSAG--IRRM 282 Streptomyces coelicolor
Q8Y0R0 169 VACLSDRGGVLLMRPLLLHASSR--SAGalSRRV 200 Ralstonia solanacearum
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