2IF6


Conserved Protein Domain Family
Peptidase_C92

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pfam05708: Peptidase_C92 
Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
Amidase_YiiX is a family of permuted papain-like amidases. It has amidase specificity for the amide bond between a lipid and an amino acid (or peptide). From the structure, a tetramer, each monomer is made up of a layered alpha-beta fold with a central, 6-stranded, antiparallel beta-sheet that is protected by helices on either side. The catalytic Cys154 in UniProtKB:Q74NK7, Structure 3kw0, is located on the N-terminus of helix alphaF. The two additional helices located above Cys154 contribute to the formation of the active site, where the lysine ligand is bound.
Statistics
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PSSM-Id: 399019
Aligned: 16 rows
Threshold Bit Score: 139.823
Threshold Setting Gi: 81792730
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IF6_A             4 QPQTGDIIFQISR-SSQSKAIQLATH----SDYSHTGMLVMRNK---------------------K-PYVFEA--VG--- 51 
jgi:Cphamn1_0157  31 RLENGDIILRYGK-GLWSQFFRDVSRr--dKRFSHAGIVVREEG---------------------A-FYVIHAaaAEltg 85  Chlorobium ...
jgi:Rmet_1902     13 TLQVGDIVFIRVR-ARPFREVATATA----SWTNHVGIVVANSG---------------------TgTSIAESt-FP--- 62  Cupriavidus...
Q8ZNV4             8 QYETGDIVFTCIG-AALFGQISTASQ----CWSNHVGIIIGHNG---------------------DdYLVAESr-VP--- 57  Salmonella ...
Q1CXU9            27 RLQTGDIVLHTSR-SSQSQAIQKATQ----SPLSHVGMVEVTEQ---------------------G-AWVVEA--VQ--- 74  Myxococcus ...
P32167            20 qPQTGDIIFQISR-SSQSKAIQLATH----TDYSHTGMLVIRNK---------------------K-PYVFEA--VG--- 67  Escherichia...
Q8P4Z8            18 RLHDGDLLFVTAArTGLSGAIDDATAtqgaPSFDHVGLVAHDGR---------------------A-RVVLHAd-EE--- 71  Xanthomonas...
Q9Q920            10 YAPKGSVIFINYK-FSLTEFFNP-------SEDKHAAIYIGQSTkttyd-----------llhytDeRWIVEAtyKN--- 67  Rabbit fibr...
Q6TUV7            10 YTPKGAIIFLNYR-FSLTEHFNP-------SEDKHAAIFIGSIPskn---------------kttYeCMAVEStfNN--- 63  Yaba monkey...
jgi:Ppro_3370    294 SLKAGDILLEKTP-FRLTDKLIP-------GYWGHAAVWIGTEVelkelgiwnnplvarhhdeirQgRLVVEAlrS---- 361 Pelobacter ...
2IF6_A            52 --PVKYTPLKQWIAHg--eKGKYVVRRVEGGlsVEQQQKLAQTAKRYLGKPYDFSFSWS-DDRQYCSEVVWKVYQNALGM 126
jgi:Cphamn1_0157  86 vgKVTCDPLGAFLEA----SSDYAVYRLAVS--GPVRQKIAHNARNYLGVSFDTSFDLSeQERLYCTEMVMQAVNKATGF 159 Chlorobium ...
jgi:Rmet_1902     63 --LSRTTSLKRFAARs--eHGRIAIARLRQPltASQQLRLSEAVRHRMGIWYDTGFNLH-SRRQFCSRFVREVLAESADI 137 Cupriavidus...
Q8ZNV4            58 --LSTVTTLSLFIQRs--aGQRYAVRRLCGGltVEQKLAIMEQVPARLNKFYHTGFKYE-SSRQFCSKFVFDIYKEALCI 132 Salmonella ...
Q1CXU9            75 --PVQRIRFSKWKARg--aKGGILVLRPRELs-DAQRQQAVAAAKAHLGKPYDWLFGWG-DDAMYCSELVRKAYAQGAGL 148 Myxococcus ...
P32167            68 --PVKYTPLKQWIAHg--eKGKYVVRRVEGGlsVEQQQKLAQTAKRYLGKPYDFSFSWS-DDRQYCSEVVWKVYQNALGM 142 Escherichia...
Q8P4Z8            72 --GSRQQPLADFIRQarakQRQIFVYRLNAAq-RAAIPDAIAQARRMLGKPYNLTYVQD-DNSYYCSDFIERAFRAH--- 144 Xanthomonas...
Q9Q920            68 --GVNKISVQELVQD----ATNIKVYILDDYnfETKMSIAADIATSFIGTPYGFG-----SNNLYCFKLVADCY-KTLGV 135 Rabbit fibr...
Q6TUV7            64 --GVNTITVDNLLKD----LTSVRVYILNSTdfISKMSIASESALGFLGMPYGFG-----KKNMYCFKLVAECY-EPLGI 131 Yaba monkey...
jgi:Ppro_3370    362 --GVEMNTLQHFLN-----IDSLGILRKPDQs-REARATTIMLALRQVGKPYDFNFDVEsKERVYCSKLVYLSY---SGI 430 Pelobacter ...
2IF6_A           127 RVGEQQKLKEFDlsnplvqaklkerygknipleetV------------------------VSPQAVFDAPQLTTV 177
jgi:Cphamn1_0157 160 VVIRPTAASGIA-----------------------V------------------------VAPDNCYEHRLVRSV 187 Chlorobium phaeo...
jgi:Rmet_1902    138 GVGEAETFKALLarq------------------pdAalgfwrlwyf-----gripweretVTPASLLCSPALELL 189 Cupriavidus meta...
Q8ZNV4           133 PVGDIETFEELLhsn------------------pdAklafwkfwfl-----gsipwdrktVTPASLWHHPNLELI 184 Salmonella enter...
Q1CXU9           149 EYGKMERLDSLRvkg------------------leQqlrerygk--------rvpldlelVTPASIAADVRLEVV 197 Myxococcus xanth...
P32167           143 RVGEQQKLKEFDlss------------------pqVqaklkeryg------knipleetvVSPQAVFDAPQLTTV 193 Escherichia coli...
Q8P4Z8           145 ---QVFALQPMNfkn------------------pqSgqmsaywtefyrskgmdvpqglpgTNPNDMARAPALQAL 198 Xanthomonas camp...
Q9Q920           136 VLPTYNILGKRVy------------------------------------------------LSQSFTCSKQWRRI 162 Rabbit fibroma v...
Q6TUV7           132 KTPTYKLLGKKIy------------------------------------------------LSQSFKYCNTWKKI 158 Yaba monkey tumo...
jgi:Ppro_3370    431 DWPTRKSLGRTTftp--------------------------------------------ddVATKVAKDGALQLV 461 Pelobacter propi...
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