3GTY


Conserved Protein Domain Family
Trigger_C

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pfam05698: Trigger_C 
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Bacterial trigger factor protein (TF) C-terminus
In the E. coli cytosol, a fraction of the newly synthesized proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co-chaperones. Trigger Factor is an ATP-independent chaperone and displays chaperone and peptidyl-prolyl-cis-trans-isomerase (PPIase) activities in vitro. It is composed of at least three domains, an N-terminal domain which mediates association with the large ribosomal subunit, a central substrate binding and PPIase domain with homology to FKBP proteins, and a C-terminal domain of unknown function. The positioning of TF at the peptide exit channel, together with its ability to interact with nascent chains as short as 57 residues renders TF a prime candidate for being the first chaperone that binds to the nascent polypeptide chains. This family represents the C-terminal region of the protein.
Statistics
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PSSM-Id: 399012
Aligned: 45 rows
Threshold Bit Score: 78.4427
Threshold Setting Gi: 281500761
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3GTY_X 247 TLEQLKESLKKEGKEIYDVEMKESMREQLLEKLPEIVEI-EISDRTLEILVNEA----INRLKREG---------RYEQI 312 Thermotoga maritima
Q8S9L5 379 TLKEVEETLAKRCQEMEQEAKEQATDNAILEQIRKMVEV-EIPQSLFEEQGRQF----YGARLLEIqgnmklnedQLASL 453 thale cress
P75454 275 SLKEFKTYFHKLVSAKKLEITLQENSVKIRQFFLANTTLpYIPDSLIKLESDRL----LRAQKDQAeqyk-ipfeRLLAA 349 Mycoplasma pneumoniae...
Q9PQE4 274 TVQELKDYIHNQIVLAKQEKNSERAWLEIAQQLLAKAKItPIPQSLIDREVSTL----RQQVLSQLsqyk-ielkQYLEF 348 Ureaplasma parvum ser...
Q98R01 270 NLEQLKEYLRPSIEHKLLEDSLTEFKNEAFNKIKELNDI-KIPRGLLLEEMTAI----NEKFNETLkaqg-lkrrEYLEM 343 Mycoplasma pulmonis U...
O51555 272 TLDDLKNFIRSSLLNIVEEKKETLKLNKFFSTISEKLEI-DIPHSMIEAEIEIA----FKDAKRQNknnm--sleEFKSI 344 Borreliella burgdorfe...
O83519 266 TLDDLTRSVRQNLAEALEAALHEYKRRQLLRILVRENPF-SLPESLVVGEMESRwalvMRQF--------------GVSL 330 Treponema pallidum su...
O84713 273 SLEDLKKKLRIQLENQAKEAQHQKRFSDAEDALAQLIDF-DLPESLLQEREELL----SREKLLNArl------vKYCSD 341 Chlamydia trachomatis...
Q8KB57 257 KVEDFRNDIRLQLQAHFSDKSEYDLLEAISSKLIEEHPV-PTPSAMVAHFQNIL----LENAKRQVggq----fpKGF-- 325 Chlorobaculum tepidum...
Q9JZ37 264 dVAKMREEVQKNVSREVERRVNEQTKESVMNALLKAVEL-KAPVALVNEEAARL----ANEMKQNFvnqg-madaA---- 333 Neisseria meningitidi...
3GTY_X 313 VSSyeSEEKFREELKERILDDIKRDRVIEVLAQEKGISVNDEELEKEAEELAPfw--giSPDRAKSLVKARQDLReELRW 390 Thermotoga maritima
Q8S9L5 454 SSQk-AVNEFLETQRESITNIIKQNIAVGDIFKRENLEFSTDELVKEVENSIS------EFKKHKQEFDEERVKD-QVQE 525 thale cress
P75454 350 SKL--SLEQLQQRNIKEARDNVTFALVMKRIADVEKIKVDNKKIHSEIESIIDveypfvNAELKKQMFHNMEQQKdFVES 427 Mycoplasma pneumoniae...
Q9PQE4 349 SKK--SEAQFQEDLIRQAKETITLALLVDDIAETQNIVVSDEEVKERVAEMAKly--qgEEQAVIEQLSKNPD---AVKE 421 Ureaplasma parvum ser...
Q98R01 344 TKL--SEEKVAEQVKKEAITKINEYLIFEQIKKAENVTISDDIIEDHYNIMAKny--niEVDKIKEFIPVDKLKE---DP 416 Mycoplasma pulmonis U...
O51555 345 FYS--SGYIGGDNLKDEILGNLKSKLIMQKMVDLDPIKVTESDVEDEMARQSKnl--gvSYEEIKKFYEDQNLIS-YLKD 419 Borreliella burgdorfe...
O83519 331 SGTpqNKLQFFQQWRPEVEEHLKQRVIVELLLKQEQVSVSAEEIETEYVRIASkt--gsKEERVREYYAGEEKRR-ALCE 407 Treponema pallidum su...
O84713 342 SELeeQKQALLEEAKADARKAVKLLFLTQKVFSEKGLSISREELQYMMDVCSRerfggyPPKDISNEMIQELVLV--ARD 419 Chlamydia trachomatis...
Q8KB57 326 -----DEREFFNAMKPNAEKHARWLLISQKIAKENNLEVTDEDIKAFAEKEAEkep-slTVDQLLNTYLSTEFKD-YIID 398 Chlorobaculum tepidum...
Q9JZ37 334 -----NLDLPLDMFKEQAERRVSLGLILAKLVDENKLEPTEEQIKAVVANFAEsy---eDPQEVIDWYYADPSRLqAPTS 405 Neisseria meningitidi...
3GTY_X 391 AILKRKVLDLLLQ 403 Thermotoga maritima
Q8S9L5 526 ILEGAKVLEWLKD 538 thale cress
P75454 428 IILNRLTTTKIIE 440 Mycoplasma pneumoniae M129
Q9PQE4 422 FLLHKKVVNYLID 434 Ureaplasma parvum serovar 3 str. ATCC 700970
Q98R01 417 NLLNEQVILKLLE 429 Mycoplasma pulmonis UAB CTIP
O51555 420 DIKRERAKKKILE 432 Borreliella burgdorferi B31
O83519 408 GIRERKLCQKLLG 420 Treponema pallidum subsp. pallidum str. Nichols
O84713 420 RLTYRKAIEAISS 432 Chlamydia trachomatis D/UW-3/CX
Q8KB57 399 TILKEKIYDVIKS 411 Chlorobaculum tepidum TLS
Q9JZ37 406 LAVESNVVDFVLg 418 Neisseria meningitidis MC58
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