3GTY


Conserved Protein Domain Family
Trigger_N

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pfam05697: Trigger_N 
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Bacterial trigger factor protein (TF)
In the E. coli cytosol, a fraction of the newly synthesized proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co-chaperones. Trigger Factor is an ATP-independent chaperone and displays chaperone and peptidyl-prolyl-cis-trans-isomerase (PPIase) activities in vitro. It is composed of at least three domains, an N-terminal domain which mediates association with the large ribosomal subunit, a central substrate binding and PPIase domain with homology to FKBP proteins, and a C-terminal domain of unknown function. The positioning of TF at the peptide exit channel, together with its ability to interact with nascent chains as short as 57 residues renders TF a prime candidate for being the first chaperone that binds to the nascent polypeptide chains. This family represents the N-terminal region of the protein.
Statistics
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PSSM-Id: 399011
Aligned: 837 rows
Threshold Bit Score: 51.7039
Threshold Setting Gi: 500775988
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3GTY_X           4 KELERdknRVVLEYVFGAEEIAQAEDKAVRYLNQ-RV--EIPGFRK------GRIP--KNVLKMKLG----EE-FQEY-T 66  Thermotoga ma...
jgi:Isop_2399   31 DITQAgpcRKHLKVEISAQDVEEEFGRALGDFSK-TA--IVPGFRP------GKAP--RTLVERRYR----Ke-VSGQvK 94  Isosphaera pa...
WP_012910699    25 KVEKPsacERHVKVSVSADDVKRYLKDAFDDLGP-KA--EVPGFRA------GRAP--RKLVEARFR----Dq-IADQvK 88  Pirellula sta...
Q7URG5           2 eVTKPhacLREVVVTIPRGEVDRYMKDAYDELVP-EA--QVPGFRA------GRAP--RKLVEKQFK----Dr-IEDRvK 65  Rhodopirellul...
jgi:Shel_11720   8 QVETLesgQEKATITIEAKEIKSRIAKKYKDYGN-KY--VFPGFRK------GHVP--RPVIEAQVG--------KEQaL 68  Slackia helio...
jgi:Olsu_0783    6 TAERPdndKVVATITVCAADVDKAIAAAYKDIAR-KY--NFQGFRK------GRAP--RPVIDSLVG----RAnVLAQaT 70  Olsenella uli...
jgi:Apar_0614    6 TADKPvdeKLTVKVTVPAAEVDAAIKQAYKDIAN-KY--SFQGFRK------GRAP--RPVIDGIVG----REaVLAQaT 70  Atopobium par...
jgi:Shel_04590   8 sekimngqKMRVKLRVSADEKAEIVQESLEALAEmARlpKDEKLRSelekqvG-ADrlASAISLSVAqncaTKpVNDLkL 86  Slackia helio...
WP_015798198     8 SDDRR---SATVTVEFESDELASKFDEVLARLQQ-QV--RLPGFRR------GKIP--RQLLVRRIG----EEeLVREaA 69  Acidimicrobiu...
Q83MU6           8 IVQRVsetELKLQVTIPSESLKPHVDRAYREVAK-TV--SVPGFRR------GKVP--VRIIDQRIG----KHvVLDRaI 72  Tropheryma wh...
3GTY_X          67 LDFLMDLIP-DTL-----KDRkli---------lsPI----Vte--reL---KDVT------ARVVVEVHEEPEVRI-Gd 115 Thermotoga ma...
jgi:Isop_2399   95 GSLLMACME-QLD-----KEYkl-----------nPIsqpnIdp--eaIqlpERGP------MTFELEIEVPPEFELpD- 148 Isosphaera pa...
WP_012910699    89 GKLLMDSMT-QIS-----EDHdf-----------sAIsepdFnf--saVdlpTDGP------MSFEFNIEVRPEFDLpE- 142 Pirellula sta...
Q7URG5          66 GSLLMDSLA-KVT-----EDAef-----------sAIgepdFdy--esIelpEKGE------FKYQFSIEVRPEFETpD- 119 Rhodopirellul...
jgi:Shel_11720  69 MDVTEDIYE-DVLpiamdEADvypiaqvkledqtaLVaeg--------------------edFVFSVIYDAKPVVEL-Ns 126 Slackia helio...
jgi:Olsu_0783   71 EDVMNDAQP-MML-----EQLdi-----------vPVdrpdygehpvaV---VEHEd-----FTTTATVLVPPACELdS- 124 Olsenella uli...
jgi:Apar_0614   71 NDLLGAAEP-QLL-----EELdl-----------vPVgrgdynqdadlP---VEGQd-----YSYEVVFNVRPEAKLdS- 124 Atopobium par...
jgi:Shel_04590  87 HILFDPELVgESIpgvfaEGPe-----------------------------------------EFSVDMVLCPEMEL-Ss 124 Slackia helio...
WP_015798198    70 EALIEERVG-DLL-----AESgldv-------igrPAla--------------rVEarpeggAEAELRVELRPSVEV-Ag 121 Acidimicrobiu...
Q83MU6          73 NDCIGDFFQ-SAV-----DEQgl-----------tPVaapkAhiaslpT---EPDAs-----LEVVFDVHVYPDVDFpA- 126 Tropheryma wh...
3GTY_X         116 ISKIEVEKVDEeKVLEKYVERRIEDL 141 Thermotoga maritima
jgi:Isop_2399  149 YTGLKVKRPTL-EITAEDVDRQLRLI 173 Isosphaera pallida ATCC 43644
WP_012910699   143 WKGLKIERLVH-EYTEDEVTQHLNKL 167 Pirellula staleyi
Q7URG5         120 WKKLELKKPVE-TISEEDVDAALQRV 144 Rhodopirellula baltica SH 1
jgi:Shel_11720 127 YDPVEIE-APFeEATEKEIDEQVEVa 151 Slackia heliotrinireducens DSM 20476
jgi:Olsu_0783  125 YDAPAINMPPA-EATEAEVDQQLEQL 149 Olsenella uli DSM 7084
jgi:Apar_0614  125 YDAPAINMPPN-EATEAEIDHQIKQL 149 Atopobium parvulum DSM 20469
jgi:Shel_04590 125 YEPVHIK-VNSlEVTDAMVDAQVAQv 149 Slackia heliotrinireducens DSM 20476
WP_015798198   122 WRDIEVRVPDP-RLTSEEVDRVIREI 146 Acidimicrobium ferrooxidans
Q83MU6         127 FENKQIEVDAI-DVTDSMVDSEIVGI 151 Tropheryma whipplei str. Twist
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