5L2R


Conserved Protein Domain Family
Fumerase_C

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pfam05683: Fumerase_C 
Fumarase C-terminus
This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Statistics
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PSSM-Id: 399003
Aligned: 118 rows
Threshold Bit Score: 240.444
Threshold Setting Gi: 122252883
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5L2R_A                 396 GIYIEQLEQNPAQYLPDIPEVHLs----tTsVKVDLKRp--IdkVRQQLSQYPVGTRVMLNGTLIVARDIAHAKIKEMMD 469
EEA05689               359 GVYMEQLEENPAQFLPDQISSSEieksseT-IHINLNLplkE--VQKILSNYPVGTRLNLNGTLIIARDIAHARILSNLK 435 Crypt...
PRJNA63271:OPIT5_05280 332 GIWLEKLETNPGRFIPAEHRQIKdd---nV-VRVDLNQpmkD--ILATLSKLPVTTRVLLNGPLVVARDIAHAKLKERVD 405 Opitu...
WP_012529322           334 GIWVEQMDDNPGRLIPERFRGKHe----hG-VRINLNQplkD--VLAELTKHPVSTPLLLSGTIVVGRDIAHAKFKEILD 406 Geoba...
jgi:Caka_1195          334 GIWFEKLEDNPGRFIPEAAEVSKpk---eA-VKIDLNRpmaD--ILAELTQYPVATPLSLTGTIVVARDIAHAKLKERID 407 Coral...
WP_012820233           329 GLWLEKMEHHPENYIPAGNAVNLa----pA-IEIDLDRpmkE--VLADLTKYPVKTRLSLKGTMIVARDMAHAKIAEIFD 401 Fibro...
CCY01671               334 GIWIEKMDTNPGELIPEEYAQPGeg--akG-ISIDLDKgidA--VRAELTKYPVSTRVSLNGTIIVARDIAHARLKAALD 408 Prevo...
jgi:Dole_0693          331 GIFVEQLETDPAQYLPTPQAKESd-----A-VRLDLDRplsE--VRNDLSRLAVGTRLLLNGPVIVARDIAHARVKEMLD 402 Desul...
XP_001608904           369 GVYIERLEHDPAQYLPPIDNNQEg----eE-IHINLDAgmeN--VLKQIRELPIKQRVLLNGTVIVARDIAHAKLNQILE 441 Babes...
Q4N0N8                 413 GVYLEELEHDPAQFLPTVKLDAPda---gE-IMIDLSIgmeK--VLEQVRKFPVKTRLLLNGPLIVARDIAHAMIVEQLD 486 Theil...
5L2R_A                 470 N---GEPLPEYMKt-------sP-IYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQSHGGSYITLAKGNRSKQVTDAC 538
EEA05689               436 E---TGKLPNYMLk-------yPfVYYAGPAKTPPNMISGSLGPTTAGRMDLYLDPFMEAGGSFITLAKGNRSEIARQAC 505 Crypt...
PRJNA63271:OPIT5_05280 406 A---GQGLPDYIKn-------hP-VYYAGPAKTPKGYASGSFGPTTAGRMDSYVDLFQSDGGSMVMLAKGNRSKAVTDAC 474 Opitu...
WP_012529322           407 S---GKPLPEYLKn-------hP-IYYAGPAKTPKGKPSGSFGPTTAGRMDSYVDLLQANGGSMIMIAKGNRSQQVTDAC 475 Geoba...
jgi:Caka_1195          408 Q---GEGMPEYFKn-------hP-VYYAGPAKTPAGKPSGSFGPTTAGRMDSYVQPFQAEGGSMIMLAKGNRSQQVTDAC 476 Coral...
WP_012820233           402 KqerGEELTDEEKtvlkvvsdhP-IYYAGPAKTPAGMPTGSFGPTTANRMDPYVMRFQSKGASMIMVAKGNRSQDVTDAC 480 Fibro...
CCY01671               409 K---GEELPQYFKd-------hP-ILYAGPAKTPEGYACGSMGPTTANRMDPYVDEFQDHGGSLVMIAKGNRTQVVTDAC 477 Prevo...
jgi:Dole_0693          403 A---GKPLPSYMTd-------yM-ILYAGPAKTPEGYPSGSLGPTTSARMDPYVTAFQPHGGALVTLGKGNRSQAVIDAC 471 Desul...
XP_001608904           442 S---TGDIPAYAKq-------yP-IYYAGPAKKPDGLVSGSFGPTTAGRMDSYAAKFMEKGASLITLAKGNRSKAFANAC 510 Babes...
Q4N0N8                 487 K---TGQLPQYIKd-------fP-IYYAGPAKRPDGYVSGSFGPTTAGRMDSYASKLMEHGASLITLAKGNRSRSFVNAC 555 Theil...
5L2R_A                 539 KKHGGFYLGSIGGpAAILAKDSIKQVTCLAFPELGMEAVWKIEVEDFPAFIVVDDKGNDMYSK 601
EEA05689               506 LKHKGFYLGVPGGpAAFHSVQKIKKLQILDFEDLGMEAVWLAEVENFLAFIVIDDKGNDFYKQ 568 Cryptosporidium muris ...
PRJNA63271:OPIT5_05280 475 KKHGGFYLGSIGGpAAILAKENIKKVELLEYPELGMEAVWKIDVVDFPAFVLVDDKGNDFFVQ 537 Opitutaceae bacterium ...
WP_012529322           476 KKHGGFYLGSIGGpAAILAEENIKKVECIDFPELGMEAVWKIEVEDFPAFILVDDKGNDFFKQ 538 Geobacter bemidjiensis
jgi:Caka_1195          477 QEYGGFYLGSIGGpAALLAEHNIKNVEVLEYPELGMEAIWKIEVEDFPAYILVDDKGNDFFAD 539 Coraliomargarita akaji...
WP_012820233           481 KKYGGFFLGSIGGpAAILAEQNILSNDIVAFPELGMEAIRKITIKDFPAFILVDDKGNNFFEg 543 Fibrobacter
CCY01671               478 KKHGGFYLGTIGGiAAVLSQECITSIECVAYPELGMEAIWKITVKDFPAFILVDDKGNDFFKQ 540 Prevotella sp. CAG:924
jgi:Dole_0693          472 KTNGGFYLGTIGGvAAILGKECITGIEVIDFPELGMEAVQRVTVKDFPAFLITDDKGNDFFKN 534 Desulfococcus oleovora...
XP_001608904           511 KKYKGVYLGSVGGpAALIAQQCITSVEVVDFPELGMEAVHKITVKNFPAFVVVDANGNDFYQE 573 Babesia bovis T2Bo
Q4N0N8                 556 KKFGGVYLGSVGGpAALIAEDCIESVEVIDFPQLGMEAVHKIIVKNFPAFVVVDAKGNDFYAQ 618 Theileria parva
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