Conserved Protein Domain Family
DUF812

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pfam05667: DUF812 
Protein of unknown function (DUF812)
This family consists of several eukaryotic proteins of unknown function.
Statistics
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PSSM-Id: 398992
Aligned: 33 rows
Threshold Bit Score: 383.209
Threshold Setting Gi: 829194557
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001031750   31 MEDTDQLLFASLQQFGFNLgNKKITSLFDV----------DGDILRSICFQFLE-FMGSKVtiNSM-----------KGQ 88   Tetrahymena t...
XP_004995815    1 MDEVDKIILLTLRQLGTDV-EEDVASLADL----------PTKAFVEGAARCIN-TINGND--EMPlsl------pgSMA 60   Salpingoeca r...
EDQ91553      453 MEEVDRIILLNLKHLGTEI-PETVQTVSDL----------GTDVFVEGCARCLN-VINQSD--EMPlkl------psTMA 512  Monosiga brev...
XP_011270107    1 MEEVDNIIIVSLRSIGCDI-PDDVASIKAF----------STDIVVDGAATALA-TINEKY--KFPrrl------pnEMS 60   Capsaspora ow...
Q01GI4          3 aADADEVLFHALRSSGIDV-HPSWSAIDDVvndvddessaNTNALLNIVRQCLC-LIDATAyeSLPrgfplddgsgtSVA 80   Ostreococcus ...
XP_002902835    1 MAEADAFISAALQQSGWLE-ADASWSVADL----------SSDALIVLVLKFLArLQDADNgvNFSlscte-akapvGVA 68   Phytophthora ...
Q54MP2          1 MDEADGIILITLKDLGCEI-EENE-TIKNF----------DSEMVYKCILAYLR-VINEQKviNLTntl------pkNMS 61   Dictyostelium...
EFA84683      358 MDEADGIILLTLRDLGCEL-GDEI-TIKDF----------DAEIVYKACLAYLR-VINEAKvaNLTati------pkNMS 418  Heterostelium...
3_pfamImport    1 MEEVDQIIIGSLLNIGCEF-AEGMTSLKQF----------TTENVVEATVKCLR-IINPDY--KMShif------ppGMS 60  
5_pfamImport    1 MEEVDQIIIGSLLNIGCEF-AEGMTSLKQF----------TTENVVEATVKCLR-IINPDY--KMShif------ppGMS 60  
XP_001031750   89 QKFRQSTQISEELKNL---CNLRIDINSLLSPSKDDLRKIVVAILQKIsmheegdnPRLNISQR---------GgAQAFD 156  Tetrahymena t...
XP_004995815   61 ARFRVGTTLATACQDLg--YGSNIGYNTFLYSNEDDCRQLLMWLIERL--------PKETTSTTgae----tlG-QEAML 125  Salpingoeca r...
EDQ91553      513 ARFQVGTTLAKACQALg--YTSSIGYNTFLYGNENDCRNILMWLIERL--------PQDVSDATqas----agTtGLARF 578  Monosiga brev...
XP_011270107   61 ARFRICTNMANACKELg--YADDIGYHQFLYSNESEVRKLFMWLVEKL--------PRESSDATae-----ptG-VSAVL 124  Capsaspora ow...
Q01GI4         81 ERFRVAGRYASALIEVggeQRDGDGFQQFLYPSASSARAMLKRLLELL--------PRRDVDEAvreaekarvSaASARL 152  Ostreococcus ...
XP_002902835   69 ARHRVGSQLANILKELg--YAGDCGYNHFLYPSEKETRNILSWLVGKL--------PRSKHEENed-----evS-KSEVL 132  Phytophthora ...
Q54MP2         62 ARVNACSLIANIIKDSg--YRSELSYHNLLYPNVNDIRKIFIFLGQLL--------PKKEVESG---------GvSIQKL 122  Dictyostelium...
EFA84683      419 ARVNSCSVLAATIRETg--YRAELSYHNLLYPNINDVRRIFVFLGQHL--------PKKEVVEG---------D-STASL 478  Heterostelium...
3_pfamImport   61 ARFRVGTSIANTCKSIg--YQGDIGYQTFLYSAERDVRQIFMFLVEKL--------PRKEGVKEd-------tG-KSNVL 122 
5_pfamImport   61 ARFRVGTSIANTCKSIg--YQGDIGYQTFLYSAERDVRQIFMFLVEKL--------PRKEGVKEdtv---qtvA-ESNVL 126 
XP_001031750  157 syedkIRYLQEQRRKEILKNWVNEEW-------------------------IHPALGNNKFNQFRMY------------- 198  Tetrahymena t...
XP_004995815  126 -----QRAITAEIDKQLSCPWIPPAFhrdglc-------------wsnnrtAWHLISRRGVRSFRSTtlftse--mdaan 185  Salpingoeca r...
EDQ91553      579 -----RAAVAADVRRRIELPFLPHAIyrdgai--------------aldakTTLQMNPRAQRPFRTNtleia-------- 631  Monosiga brev...
XP_011270107  125 -----NKAITDELEYRAEAPWTLPVAkrsgyarrvatipgptpkspptyvpHQQWEGLRGVHRLHASvvvipa--gagdv 197  Capsaspora ow...
Q01GI4        153 g---sRARAMVARSTKAEAAW------------------------------------GRAAGALKGFagvaaa--arakk 191  Ostreococcus ...
XP_002902835  133 asmgaNSSIAEAAASVLASDRLANIFsswkrek------------tlhmlpNQNVQGLRGFQRLPLQtsplelpwsrpgk 200  Phytophthora ...
Q54MP2        123 -----EDQICQYLQGCVKESWIPYFCp-----------------------fSKRIPGNYSTATLFTTtggnlr-ipsrgr 173  Dictyostelium...
EFA84683      479 -----KDLICNHLASSIKESWMPYFCp-----------------------fTKRIPGNYSTAKLFTVaplki---pargr 527  Heterostelium...
3_pfamImport  123 -----QRRIGQVLREKCSTMWMPFYCk-----------------------------pLIEGVPFRTQplfip----kysk 164 
5_pfamImport  127 -----QRRIGQVLREKCSTMWMPFYCk-----------------------------pLIEGVPFRTQplfip----kysk 168 
XP_001031750  199 DNELVLDSNSLSNKlIIDIIN----------GKMKQNLYAslakiiENRALKAQIDEMEVYADVQKIseQRHqLQIEEIK 268  Tetrahymena t...
XP_004995815  186 TARAAYETT------NQQTIPqqr----svaTSSLASILA------RNSRLLASERAREEELTAAGRdpA---LPNEDFV 246  Salpingoeca r...
EDQ91553      632 -dsngsQERVAYETeHMPLVTaqp----mrsANRLTSLLA------KHAALQARRAVWQEEWSTLGM---TSgKTEQQYR 697  Monosiga brev...
XP_011270107  198 TKPLSKELRKYYAG-ALPYLTaqp----pvrQDVAPSILE------KVSAEYTAAREWEEIWNKEGM--DTG-LSEAEFR 263  Capsaspora ow...
Q01GI4        192 RTDDTTNAREFYTSrLTTSSSggffgnlsadTYAVPSVLE-----------YAARVRAEEEAEEDARrlKFSgVVRAEFI 260  Ostreococcus ...
XP_002902835  201 STHN---------------LFekf----ssdSIKATSLLEalavakRGSTMFLREDEFDDDVEEDNV--------DAQLK 253  Phytophthora ...
Q54MP2        174 QLKVTPGLEQYYSQ-YLEPLTlqt----nrfEDIAPSVFE------YNLSIYAEAQERDNEWNDKGV--SSG-MNPIDYR 239  Dictyostelium...
EFA84683      528 QLKLTPGLEDFYIK-HLRPINqqp----nrtDDVAPSVFE------YNLSIYAEAQERENEWNTKGS--QSG-LNPLEYK 593  Heterostelium...
3_pfamImport  165 gHRNSKSQGKRQNEkKYDYIHrqv-----ehDELTPSLLE------LNCSQLIAA--------------SPTiGKTSKQG 219 
5_pfamImport  169 gHRNSKT------------------------------------------------------------------------- 175 
XP_001031750  269 KQVatevtkaSKKKVNRIAEQFTEQPQQTEEEvkqQLNEEKQTIFNLEMQFqeeqtvhnpvldpqnDEKNERslNKSNAE 348  Tetrahymena t...
XP_004995815  247 RQK-------RTTTRRTISAKVKAALFNDA--------KQEVDMAKFLAKF--------------------SgiELGKMS 291  Salpingoeca r...
EDQ91553      698 HDK-------QDSILKNMRQQLQKGIAADMTAh-----RQRQDIRTFLDGF--------------------AnvQLGKKS 745  Monosiga brev...
XP_011270107  264 DRK-------RQFVRSKMAEYVRSSALKGDGAg-fGRN-DADSFASFLDSF---------------SDRGLRn---AKGS 316  Capsaspora ow...
Q01GI4        261 GPDgkpfdlrKRGGLRGLVAEIFRLALEGGFYtepRAIQACAELEE---------------------------------T 307  Ostreococcus ...
XP_002902835  254 QGQ-------VEGLLTDATRAGESGFLSPQEAeaeDDEFATIEPQTFLSSAlpdvp-----lslnnPSSGTTdtMATEGA 321  Phytophthora ...
Q54MP2        240 KNK-------QKQVLSKMNDSIRQSIIDGGNNqisSNCNSGDSFLDIISEF--------------------RgnSLDVGG 292  Dictyostelium...
EFA84683      594 KNK-------SKTILSKMNDSIRSAMVDGSs----ADSRRNNTFDHVIGQF---------------GMGSADd----dYG 643  Heterostelium...
3_pfamImport  220 DMK-------TTKVTKEAFHWKDKSMVPANILs-fLQLPDAIPFDSSLDEV---------------IQIVTGqsLKTNRS 276 
5_pfamImport  176 -----------------------------NILs-fLQLPDAIPFDSSLDEV---------------IQIVTGqsLKTNRS 210 
XP_001031750  349 TLNSSNALlnssnSLlnsanNNSsttq----------------------------------------------------- 375  Tetrahymena t...
XP_004995815  292 MFRAKHKL-----QF-----AKE--------------------------------------------------------- 304  Salpingoeca r...
EDQ91553      746 LFRKREEL-----QF-----QSE--------------------------------------------------------- 758  Monosiga brev...
XP_011270107  317 RFTHAEKF-----QF-----TQD--------------------------------------------------------- 329  Capsaspora ow...
Q01GI4        308 QVVDEDKVvesanDV-----ENA--------------------------------------------------------- 325  Ostreococcus ...
XP_002902835  322 TTDSTGSAsigasQFavlqtAND--------------------------------------------------------- 344  Phytophthora ...
Q54MP2        293 QFNRKKAF------------TNEl-------------------------------------------------------- 304  Dictyostelium...
EFA84683      644 QFARKKAF------------TNE--------------------------------------------------------- 654  Heterostelium...
3_pfamImport  277 RFAHAKDL-----QF-----TTVnd------------------------------------------------------- 291 
5_pfamImport  211 RFAHAKDL-----QF-----TTVsddgcinyschkplqirpvipqkpshlaklenkevfylssldwgsdyfrtgfidgeh 280 
XP_001031750  376 ------askPmtsAAnnsrlslgksNLnIGINIDELKTNNSKEISTLSQKYEELQNKKQKYAKEREKMETNIQQKTEEAE 449  Tetrahymena t...
XP_004995815  305 -------------DEaa-------vAAtKTVTDEELKQQREDELSALQGEVEDLESSLQAMRDNLASLQSTAEALAEQTA 364  Salpingoeca r...
EDQ91553      759 -------------AS----------DApKAATQEELEQQRQAELEELETRLSDLMATMQSLQGELSTFDKDAVKMDSKLA 815  Monosiga brev...
XP_011270107  330 -------------EGa---------AAaVADTEEELRKRREEELRALQERLDALSAEVDRMEHEIRNFNVNTSQLESNLR 387  Capsaspora ow...
Q01GI4        326 ----------------------------AMDTLEDRIKARERDLEDVHRRIDEAMSVVSTVDDEIAACASKVKEAMEATD 377  Ostreococcus ...
XP_002902835  345 --------------------------------------NEEQSLDEVQKQVDDTERRIAAMRKVLDRERGHLQQVEQHVL 386  Phytophthora ...
Q54MP2        305 ---------NnnnNNnndsttntnkVEtEIETEEQRQLKRQAEIDALQSQIDEISESIQLHNKEMLDFLSLMRQSESENL 375  Dictyostelium...
EFA84683      655 -------------EVase-----piEPkAKETEEERQQKQQEEIDQLQSVLEELANRMANATSEMDDWIQQIRQLEAQIN 716  Heterostelium...
3_pfamImport  292 ------------pTSsvdeasssadVAkDQEELEEIRFQREED--EMNKMISDVVEDEEKYKEDLKMVEMSMKQIVVNTQ 357 
5_pfamImport  281 ltpptkdrtQddpTSsvdeasssadVAkDQEELEEIRFQREED--EMNKMISDVVEDEEKYKEDLKMVEMSMKQIVVNTQ 358 
XP_001031750  450 VLKEQNKQTKKDIENMEMLIKEL--E---TKGGSSELKKEIKELEQDIQQIEIEWKEYQETDIKKLEELKDELTKKKEKR 524  Tetrahymena t...
XP_004995815  365 RMQEENEALTKEQKVRKRVLDLLp-N---AEENMQLLKDKIDEVAAKLAALAERWEEHRVALIKEYRDLKVAAANKNSEA 440  Salpingoeca r...
EDQ91553      816 ELKALAEELAANNAVRKRVLDLLp-N---ADENIERLGQAIDALARKLIAIGEKWEPHRRELLREYQQLKSAAADQMSEI 891  Monosiga brev...
XP_011270107  388 EEKSASATKEALYRSKVKVFELLp-E---ADKNIELLQGLVSTSTKRLVELATKWEAVRAPLVLEYRTLKESQDGRMTES 463  Capsaspora ow...
Q01GI4        378 AKRALTAELESNYLLHKQAVGMVlaTdrpVEESEAELNKVLVAAKERLEQLSAEWNAAKTPLLAAIEAHAEGAREKRKKA 457  Ostreococcus ...
XP_002902835  387 ETQSTGQELQKQLARQKQLLAMLp-Q---AQANILKLEAICQSNAEKKVEISQQMGSARGPLLLEYAALEGQKSSRKARC 462  Phytophthora ...
Q54MP2        376 EQDQQREVLEKQYKIKKKTFSLLd-D---AEGNMKELQSLCNQTSSNLLEMSGEWEKVRKPIIEKYRSLKDKQNNQADET 451  Dictyostelium...
EFA84683      717 EEDRKRAELEKEYKVKKKTFGLLe-N---AEENFAKLQELCQQTSASLIEMSGEWEKVRRPIIEKYRQLKDEKANQSDEA 792  Heterostelium...
3_pfamImport  358 ELESTNEERIKQVKLKEKTLKLLp-N---AEENMEKLKAMVDASSQRLVELGKLWEEKRIPLVAEIRRLKQSKTETEFDA 433 
5_pfamImport  359 ELESTNEERIKQVKLKEKTLKLLp-N---AEENMEKLKAMVDASSQRLVELGKLWEEKRIPLVAEIRRLKQSKTETEFDA 434 
XP_001031750  525 ELIKDKIKRIDTELQQVIQDLQMAYEKKVQL----------VEDYKRMPQGGNRQEYIKKIMEIKKNYDKQRGDIQKIIQ 594  Tetrahymena t...
XP_004995815  441 RKQAESIQELRSQAKQIIADAKQKEQLFQQL----------VQDYERMNKDILRSSYTSRILEIVKSIDKQKREIQKILV 510  Salpingoeca r...
EDQ91553      892 KVQMAYVQEMRETTQGILAGAKAKEQRVAEL----------QAEYEKRNNATQRSWYVERILEIIKSINKQSADIETSIL 961  Monosiga brev...
XP_011270107  464 RRKLAQIKEFRESMKQIAEEARIKDELYRQL----------TAEYEKMTKDINRSIYTRRILEIVKNIKKQREDIDKVLI 533  Capsaspora ow...
Q01GI4        458 KNQLEEIEKWRSEGKDTSSLLRIKEQEQRQL----------LDQYEAAPKSVHRPSFVRRVNEIIKNIKKQEREIVKIVG 527  Ostreococcus ...
XP_002902835  463 RQLIREMKAFRAEMLEISGIIQSKMESLKALervqerqlakLGQKKDADGPMTRNMYTSRIMDIIKQVHKQKQDIAKILD 542  Phytophthora ...
Q54MP2        452 KSKLDRIKEMRILIKKLVSEVQQKDDQFQQL----------QDQYKQAPKDSNRSQYTRRILETVKNIKKQKVDIDKVLL 521  Dictyostelium...
EFA84683      793 KSKVERIKEIRALIKKMIADIRAKEELFTQL----------QDTYKAMPKDTNRSMYTRRIIESVKNIKKQKEDIDRILL 862  Heterostelium...
3_pfamImport  434 ERKVEEIRLLRSRMKDVSEETKQKDQLIKQL----------KTELDSVKRDISRQSYTRRILEIVASIHKQKQEIQRVIE 503 
5_pfamImport  435 ERKVEEIRLLRSRMKDVSEETKQKDQLIKQL----------KTELDSVKRDISRQSYTRRILEIVASIHKQKQEIQRVIE 504 
XP_001031750  595 DVKSVEESIQYYQGTLERHMNELEAIYNTDAKK--NESLSK--QifkiYQEYRTI---FDQTVNNLREVGNKMIESRSIE 667  Tetrahymena t...
XP_004995815  511 ETRGLQKDLGLLEGKIERTFTVAEEEIFKESKA--NPAARL--A----YKHLANLhaeCGRLIDVVKSTGTVAREIRDLE 582  Salpingoeca r...
EDQ91553      962 DIRAMQREINQISDRLSRQFTVVDEMVFKDAKK--DADIKR--A----YQLLASLhtgCEDLIQCVENIGSLEKECRELD 1033 Monosiga brev...
XP_011270107  534 ETRALQKEINHTSDVLNRTFSATDELIFKDAKK--DDACRR--A----YKYLASLhehCNVLIADVENTGKLLNEIRDFE 605  Capsaspora ow...
Q01GI4        528 DTRSVQSDINSAQACLERTYTVVEEILFREARS--DELCRA--A----YKHLHGMhagFADLIDKVEATGVARRSQTDLQ 599  Ostreococcus ...
XP_002902835  543 DIKGLQKQLNTASERLKRTEAVAEDKLYSAASTskSTSSTKadAyvecYRKFAQVrelFEELIVVVGDVGKKENAARDLQ 622  Phytophthora ...
Q54MP2        522 DTKNLQKEINTITDTAVRTFELVKDLLYNDAKK--DQTAKQ--A----IKSFAIIddkFQKLFKTIDETGNFQNNILNLN 593  Dictyostelium...
EFA84683      863 DTRTLQKEINTITDTAVRTFDAVKDMLYADAKK--DQTAKT--A----IKSFAVIdekFQTLLTAIDETGTYQNNIFTLT 934  Heterostelium...
3_pfamImport  504 DVKLVQKTMNKLKGRANRTFSAADEVIFRDAKQ--DEGSKQ--A----YKYLVSLhdnCAALLKTVEETGLIMREIRDLE 575 
5_pfamImport  505 DVKLVQKTMNKLKGRANRTFSAADEVIFRDAKQ--DEGSKQ--A----YKYLVSLhdnCAALLKTVEETGLIMREIRDLE 576 
XP_001031750  668 AK 669  Tetrahymena thermophila SB210
XP_004995815  583 DQ 584  Salpingoeca rosetta
EDQ91553     1034 NA 1035 Monosiga brevicollis MX1
XP_011270107  606 EK 607  Capsaspora owczarzaki ATCC 30864
Q01GI4        600 RK 601  Ostreococcus tauri
XP_002902835  623 NW 624  Phytophthora infestans T30-4
Q54MP2        594 SK 595  Dictyostelium discoideum
EFA84683      935 SK 936  Heterostelium album PN500
3_pfamImport  576 GQ 577 
5_pfamImport  577 GQ 578 
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