Conserved Protein Domain Family
RPW8
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pfam05659: RPW8 
Arabidopsis broad-spectrum mildew resistance protein RPW8
This family consists of several broad-spectrum mildew resistance proteins from Arabidopsis thaliana. Plant disease resistance (R) genes control the recognition of specific pathogens and activate subsequent defence responses. The Arabidopsis thaliana locus Resistance To Powdery Mildew 8 (RPW8) contains two naturally polymorphic, dominant R genes, RPW8.1 and RPW8.2, which individually control resistance to a broad range of powdery mildew pathogens. They induce localized, salicylic acid-dependent defences similar to those induced by R genes that control specific resistance. Apparently, broad-spectrum resistance mediated by RPW8 uses the same mechanisms as specific resistance.
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Statistics
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PSSM-Id: 398988
Aligned: 13 rows
Threshold Bit Score: 150.136
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEF40015       3 ADL-----VGGAVLGAILGELLEAVLRAKNRTFMFKSILKRMECTLETVTPIVKEIEELNKVL-DRRNeEMGIIMKEIRK 76 
EEF40016       6 ASA-----AAGAGLELAFGSLLRIILEVRRKNVMFASTLQILIDTMEAIRPSIKRIDSFNTDF-DRPD-EIKGLRDLIRK 78 
CBI23299       3 lEL-----VGGAALGAVFEKLFAAVVDASNKATQFESSLKKLEETLKSINPSILEMKKLNDEL-DRPKeEMEKLIQILKD 76 
XP_010316804   3 GNL-----IGGAAIGQAFRMLSESITEAGKTSVCFDSNFRRLNSTLLSIKPVLEDIERLNKAL-EGREsETELFNKRLEE 76 
Q9SCS6         4 AELaviktVGGPLIAAALGVGAQVIYDGFRKGKDT-SIINRLGRTMESISPVRDRIGKLSNVEgKPFReVHESLTRLLED 82  thale cress
Q9SCS7         4 SEI-----MAGAALGLALQVLHDAIKKAKDRSLTTRCILDRLDATIFRITPLVTQVDKLSEEVeDSPRkVIEDLKHLLEK 78  thale cress
XP_009115720   4 GEV-----LVGAALGITLQVLHEAIIKAKHRSLTTKCILDRLDATISRITPLVVHVDKISKRVeDSERkVIEELKRLLEK 78 
XP_009136547   3 IEL-----MAGAALGLALQVVHEAIKKAIERSLSTRYILYRLEDTISRITTFVAQVDKLSEEVeDSPRkIIEDLKNHLDN 77 
EFH52292       4 AEI-----IAGAALGLALQILHEAIQRAKDRSLTTSCILDRLDSTILRISPLIAKVEKLGKESdESMRkVIKDLKHLLEK 78 
XP_002876032   4 VEL-----FAGAALGFALQLLHEAIIRAKERSLITRCILDRLDATIYKITPFVNKIDTCTEEVdEPLRkVIEELKCLLEK 78 
ERN14425       1 mDL-----VSGAIIGAIAGEILKALLDATNIVYECKSQCEKLKSTLQHIVPKLEDIEQLRLQLtDCEPaDFKELKSRLES 75 
EFH70101       1 -------mVGGAFLGAPVSEILKLVIEEAKKVKDFKPLSQDLASTMERLVPIFKEIDSMQ----QRCNgELIVLIKTLER 69 
Q84WJ0         7 ASL-----VGGAALGAPLSEIFKLVIEEAKKVKDFKPLSQDLASTMERLVPIFNEIDMMQQGS-NRGTsELKVLTETMER 80  thale cress

EEF40015      77 GKKLVLECSGMQwYYACWRTPKYAGKLIKLEKSLKLFFQIVMQAQRARDGKEALLE--MKDLRMDLKR 142
EEF40016      79 GEDLVIKCSKVH-KYNYVKKPYYTKKLIKLDESIRRYISTILPLYQTSDIKETLYE--MRVLSTQIRN 143
CBI23299      77 GEKLIHKCSKVS-CCSCFKKWRYANKIEALEDSLLNFFQVELQAQLGRNNVEILVM--LKSNRFSlsn 141
XP_010316804  77 GEKLVRKSAKIK-RYNVCKRWYYSKKLADLEKSTMNFFEVHGLMQSCRDRKKILVA--LKEEGEKLDE 141
Q9SCS6        83 AKSIIEKYWKLRwSRHVCRKYRYIKKLESIELELVR-VAREIQVHQWTDIKEMKAI--QVHQWTDIKE 147 thale cress
Q9SCS7        79 AVSLVEAYAELR-RRNLLKKFRYKRRIKELEASLRWMVDVDVQVNQWVDIKELMAK--MSEMNTKLDE 143 thale cress
XP_009115720  79 AVSLVEAYAELR-RRNLHKKHWCKSRIKELEASLRWMVDVDVQVNQWLDIKELVTK--MSEMNTKLDK 143
XP_009136547  78 AASLLKAYAELR-RRNLIKKYRCRRSIKELEASLRCMINVDVQVNHW-DIKKLMAT--MSETNTKLQp 141
EFH52292      79 AVVLVEAYAELK-RRNLVGKYRYKRRIKELEGSLKWMVDVDVKVNQWADIKDLMAK--MSEMNTKLDK 143
XP_002876032  79 AIRLVEAYAELK-RRNLLRKYRYKRRIKELDASLRWMVDVDVQVNQWLDIRKLMGK--MSEMNTKLDE 143
ERN14425      76 GKVLVYKCMKLR-FWKVHKKYSYGKKLIELDEYLVRFFDLNLAADTNLDTKQLRIE--FKEMRRLLDg 140
EFH70101      70 AEKMVSKCSGVK-WYSISKKALYTREIKEINQEFLKFCQIELQLIQHRNQLQSMQS--MASVTMNIDL 134
Q84WJ0        81 AGEMVHKCSRIQ-WYSIAKKALYTREIKAINQDFLKFCQIELQLIQHRNQLQYMRSmgMASVSTKADL 147 thale cress
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