6GBS


Conserved Protein Domain Family
DcpS

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pfam05652: DcpS 
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Scavenger mRNA decapping enzyme (DcpS) N-terminal
This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the N-terminal domain of these proteins. DcpS is a scavenger pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway.
Statistics
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PSSM-Id: 398983
Aligned: 113 rows
Threshold Bit Score: 96.8211
Threshold Setting Gi: 568254950
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6GBS_A               11 ALVPRFQFERLLNQDQAGRRSALYGAIDG-----QPALLILERAPFPTST-A---------------------------- 56  Chaetomi...
XP_011146695         39 TDLSDFNVTRVLQNNCARKLICVEGTFKDr---aDPAIVLLEQKSFPSDKv----------------------------- 86  Jerdon's...
EGI57894             43 lNLSDFKVTRVLQNNCARKLICMEGTFENr---eGQAVVLLEQKSFSQDKv----------------------------- 90  Panamani...
XP_001990602         22 YDLTKFCLKRILNNNSKFKSITLLGTFPDls-etDAAIVVFEKNAYRESDvatevpa----------------------- 77  Drosophi...
WGS:AAQB:GK13922-PA  18 YELKKFQLKRILNNNTVRKSIALLGTFPDls-sdNPAIVVFEKNAYRESDvatdes------------------------ 72  Drosophi...
EDW25131             15 YDISKFRLKRILQNNSVRKSIALLGTFPDls-etDDAIVVFEKTAYQESDvstsk------------------------- 68  Drosophi...
XP_002045624         15 YDLSKFQLKRILTNNSVRKSISLLGTFPDlg--tDDAIVVFEKNAYRESDvatass------------------------ 68  Drosophi...
Q16XY1               70 YDLAHFEPVRILSNNSTHKSVSLLGHFANls-rdDFSIIVLEKTAFTEAQlRnttsseseskhs--------------st 134 yellow f...
ETN63834             40 yDLAHFRTVRVLSNNSTHKSVCLLGHFANlpapeKQAIVVLEKRSFTEGQvLtpksqsddeqhenhksesendnsslaet 119 Anophele...
XP_001847826         70 fQLSQFELVRILSNNSTHKSVALLGHFGDls-reQQAIVTLEKTAFTEGQlQttttt----------------------- 125 southern...
6GBS_A               57 ----------YLGRA---ANTLRAltnLGANDIYHWYLA--SsgvieipveesegtdDEFADLKINLIYPCTEKHVKKYS 121 Chaetomi...
XP_011146695         87 ---------sLKKGFfseKTIYQK---NCANDIYGNYDCfpA---------------EEYNSLHATVIYPATRNQIEKYL 139 Jerdon's...
EGI57894             91 ---------vLEKDFfdgKTTFRK---IFTNDVYRNYNCfpT---------------EENNGLHVTVIYPASQTHIDKYK 143 Panamani...
XP_001990602         78 ---ekeseseKKPSYfssDLKVRT---DFVNNIYASFQCvpT---------------QELCAVKSTVVYPATEKHIQKYS 136 Drosophi...
WGS:AAQB:GK13922-PA  73 -----etldkEAPSYfskDLNVAT---QFINNIYGSYQVvpR---------------QELCAVKSTVIYPATEKHIQKYS 129 Drosophi...
EDW25131             69 ------elpaK-PSYfsaELKVDT---EFINNIYGSFQVvpS---------------PDLCGVKSTVIYPATDKHVEKYS 123 Drosophi...
XP_002045624         69 -----eespkK-PSYftaDLKVDT---EFINNIYGSFQVvpT---------------RNLCSVKSTVIYPATEKHIEKYS 124 Drosophi...
Q16XY1              135 ttaeadteaeR--SIfstKSHLRT---EFINDIYGNFLCvtD---------------PEVNQLKVTIVYPATEKHISKYS 194 yellow f...
ETN63834            120 ktaddgapheREQTFftsASRLEK---EFVNDIYGNFLCtvD---------------PALNRLKVTIIYPAEEKHIVKYT 181 Anophele...
XP_001847826        126 ------geseR-NSFftsKSQLRT---EFINDVYGNFQCltD---------------PEINQLKVTIIYPASEKHIVKFA 180 southern...
6GBS_A              122 KQ 123 Chaetomium thermophilum var. thermophilum DSM 1495
XP_011146695        140 KQ 141 Jerdon's jumping ant
EGI57894            144 RQ 145 Panamanian leafcutter ant
XP_001990602        137 ic 138 Drosophila grimshawi
WGS:AAQB:GK13922-PA 130 ic 131 Drosophila willistoni
EDW25131            124 ic 125 Drosophila persimilis
XP_002045624        125 vs 126 Drosophila sechellia
Q16XY1              195 Ah 196 yellow fever mosquito
ETN63834            182 VQ 183 Anopheles darlingi
XP_001847826        181 AQ 182 southern house mosquito
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