3DWB,3ZUK,4XBH


Conserved Protein Domain Family
Peptidase_M13_N

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pfam05649: Peptidase_M13_N 
Peptidase family M13
M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.
Statistics
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PSSM-Id: 398980
Aligned: 785 rows
Threshold Bit Score: 76.9395
Threshold Setting Gi: 308496092
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DWB_A         21 PCHDFFSYACGGWIKAN-PV-PDGHSRWG-TFSNLWEHNQ-------------------Ai-IKHLLe-N--STAS--VS 72  
XP_002416301   23 PCQDFYKFTCGGWEKSH-PG-FHDQMEY--AYGSVVTEITk------------------N--LKKVM-----VPQAn-QS 72   black-legged ...
EGT35769      172 PCEDFYEHTCGLMYEH--SR-EDNSFSHI-RYKELPYRVFh------------------I--IRNAK-----KFAS--KP 220  Caenorhabditi...
CAP25066      717 PCEDFFEHSCGRLHEH--ML-EDSNWGYS-QFRMLMYQVFcefffrffslkifkkkipaI--IRKTK-----KFTS--RP 783  Caenorhabditi...
XP_003109896  112 PCDDFYGHVCGRYPEH-----TTDDSGWG--HKQLQRL---------------------TyqIFSLVr---kTKKFs-TK 159  Caenorhabditi...
O16636         49 PCEDFFEHTCGRYSEH--VM-DDNSWGYV-QYKQLLYQVFa------------------I--ARKTN-----KFNS--KP 97   Caenorhabditi...
EGT33814      120 PCDNFYQFACGGWINQ--SV-NLKYDSWNtLYETQRTSHDq------------------I--VQAMHk-IndGSYPlpTN 175  Caenorhabditi...
PDM62546      129 PCDDFYEYVCAGWMENTvKR-TKGPAEWN-AIHETAFRAF-------------------Dr-IEHVLt-Q--IMQSppLL 183  Pristionchus ...
EGT34392       85 PCQDFYQAACGKYNEQN-TVeGPRFLK---AFEINLNLVTe------------------H--LEKNL-----PTTS--KS 133  Caenorhabditi...
XP_003110234  146 PCHDFYKYSCGRYQEHV-PF-AGDS------FDRKTKILK-------------------Ll-IEDFLtkN--VPST--SK 193  Caenorhabditi...
3DWB_A         73 EA-ER---KAQVYYRACMNETr--iEE-LRA-KP-LMELIERLG--G-----WnitgP-------------------WA- 116 
XP_002416301   73 -A-VE---KAAAVFQSCVHMIn--rES-SNR-DA-LLRFIGSIGi-Iwp--sG----Gt------------------VN- 116  black-legged ...
EGT35769      221 -N--E---QMRLFLNQCMNQAg--mEA-DTL-KD-LREDIEMRG--Gfp--fI----Ded----------------wDEs 265  Caenorhabditi...
CAP25066      784 -K--E---QLRIFAKKCLDRGamnkDNlEG-----LRKDIQMRG--Gfp--mI----Dsn----------------wDEs 828  Caenorhabditi...
XP_003109896  160 -P-NE---QLRIFTKKCMDRAg--mDS-DSL-QY-LREDIEKRG--Gfp--lI----Dpd----------------wNEa 205  Caenorhabditi...
O16636         98 -N--E---QLRIFTKSCLDRKe--mDE-DTF-QD-LRNDIEERG--Gfp--mI----Dpn----------------wNEe 142  Caenorhabditi...
EGT33814      176 AG-ER---AAAKMYEQCMDTDt--lEQ-TGL-HL-WERFVDELG--G-----W----MpelkngmleqeesfeieldEDe 235  Caenorhabditi...
PDM62546      184 KElTNsqrDAVNTYQKCMADNv--eDA-AAV----FAYVDKEVG--G-----W----Itt----------------aTN- 228  Pristionchus ...
EGT34392      134 -E--Q---AMRSYFQKCKESKt--kNAtEEK-DEmMRELYQNIQkiGsfpmmN----Knw----------------tES- 183  Caenorhabditi...
XP_003110234  194 -S-EK---SMKILYAKCKKAEl--wSEeRDFfQQ-VYRHISSIGswShf-rfI----Plg----------------vDTn 244  Caenorhabditi...
3DWB_A        117 ----KDNFQDTLqVV-TAH-Y---RTSP--F-FS--V-YVS--AD--------S-KNsn-----sNv---IQVD-Q-S-G 159 
XP_002416301  117 ----SLKALDVL-VH-LS--L---SL-D--IhIL--V-TVG--LY--------E-AHtg-----tYs---LRIS---V-P 156  black-legged ...
EGT35769      266 ----KFDLSEML-ANyIKInR-----------LR--LpFIA--VE--------SfKNpl----nnNan-gLYIS---P-G 308  Caenorhabditi...
CAP25066      829 ----KFDLSEML-SKyLSInR---N-----R-MG----FLS--VE--------PfTTveng-tvvNm---LYVG---P-G 872  Caenorhabditi...
XP_003109896  206 ----KFDLSDML-ANyLSLnRkrmG-------FL------S--VE--------PfEAvq----dgQivslLFLG---P-G 249  Caenorhabditi...
O16636        143 ----KFDLSDML-AKyLSInRnrmGFLSveP-YA----AIE--GN----------KSvn----------rLYVS---P-G 186  Caenorhabditi...
EGT33814      236 kkrrRFEIEDII-LSaFN--Y---S-------VFplF-WAGveVN--------Y-LDsk-----eHl---ITIYeQlP-I 283  Caenorhabditi...
PDM62546      229 ----DMRLEDVL-VG-SYR-M---NAIs---vFA--I-AAV--VN--------P-KDnt-----hAa---LTIE-E-A-V 270  Pristionchus ...
EGT34392      184 ----DFDLNEMM-VN-MAS-T---GK-T--D-FG--IfELE--PT----------EDs------qIi---IY-----P-S 220  Caenorhabditi...
XP_003110234  245 ----LTKWLSGL-RL-LKKsLesqSV----D-FG--LfSIK--FNdhskmtieP-KHillrppsvMmt-nIHTLlR-HnG 306  Caenorhabditi...
3DWB_A        160 ------LGLpSRDY-Y-LNK-TEne-----------kvLTGYLNYMVQLGKL----LgGgdE-E-------AirPQM--- 204 
XP_002416301  157 -------QKvVHEY-L-NDD-RI------------------SQERIKEVLTLmf--ghS--N-F-------D--AML--- 191  black-legged ...
EGT35769      309 p---------HYYY-YyTMA-LSh-------------nKEATAQLIRRLLKL------E--NrElee-defE--EVF--- 350  Caenorhabditi...
CAP25066      873 p---------QYVYnYamsi---------------giyKDSVAFILERLLKLe---N------RtlnrteyE--EEF--- 914  Caenorhabditi...
XP_003109896  250 ------PHFvDSIA-Fnvsf---------------ykeSVAF--MLERLLQLenrtM------Ntae-fskA--YE---- 292  Caenorhabditi...
O16636        187 phwvynWAMgISIY------------------------KDSVAFMLRRLLKL------E--N-RelnetiyD--KEF--- 228  Caenorhabditi...
EGT33814      284 ------LLApEKYH-Y--DKeLTpemiygk--megppvTRALQQVGEELAAV----Lg-----FdssdekvR--MMI--- 338  Caenorhabditi...
PDM62546      271 ------PILgTVAH-Y-AAP-VEydvdlllagkagnplLNILKTTGYEVAGM----LgMe---I-------T--KEFeig 325  Pristionchus ...
EGT34392      221 -------TYsHAAY-NfFFN-SGnk------------iFLKFMKHYAEVNNL----D-S--KdF-------E--PDQ--- 260  Caenorhabditi...
XP_003110234  307 ------IDVpDSQLsv---------------------rISQLGDFLNKLNYI-----------P-------R--EDV--- 336  Caenorhabditi...
3DWB_A        205 -QQILDF---E---TALAN-ITip---qEKRrDEELIy----HKV-----------TAAELQ--T-La-PAIN---WLPF 251 
XP_002416301  192 -KVITIF---E---KKISNtLHsv---iAVR-RFTDTi----QIl-----------NIGTYTp-N-Q--PSSE---WISA 238  black-legged ...
EGT35769      351 -QEMVAF---E---AEIQG-LAkp---lEVRaDPSLIs----KMK-----------TLAELQe-R-V--PEID---WFRV 397  Caenorhabditi...
CAP25066      915 -QKLVDL---E---ERFAN-VScqf-fsEKL-KNSKFqladyKNLnldndnmskakNLSDLA--K-Mi-PEID---WYKI 977  Caenorhabditi...
XP_003109896  293 --EIMDL---E---ASFVK-LGdysnirIDT-DDMSK-----TR------------NLSELA--KmV--PEID---WFKI 338  Caenorhabditi...
O16636        229 -AELVQL---EanfSTLAD-YRnl---aLDN-DNMSK-----SR------------NLTDLV--KmI--PEID---WIKI 275  Caenorhabditi...
EGT33814      339 -ANMIYL---E---YQIT--IAgs---tFYK-EKKERy----TVV-----------TLRELQ--EiA--PAIN---WHYF 383  Caenorhabditi...
PDM62546      326 lAHAILF---D---TKLAR-ISp----lLHG-DSDMQ-----MET-----------TLGDLR--Q-MagSSFD---FYHF 371  Pristionchus ...
EGT34392      261 -KAVTDLagvE---KFLA--SIre---mGKF-QISDFf----DEt----------iDFEELQe-L-V--PSLD---FEGR 309  Caenorhabditi...
XP_003110234  337 -SSVIEY---E-------Ka-------nLKSrIPAIDf----DA------------IIKDMMrsS-E---GFEvvkKNTF 378  Caenorhabditi...
3DWB_A        252 LNTi-------------FYPVeiN---------ESEPIVV-Y--DKEYL----EQISTLIn----T-TDr---CLL-NNY 293 
XP_002416301  239 INK--------------QLSI--Kka-----isKRTRVRV-D--DIAYL----EAISELIv----ElEDq---TLL-SWF 282  black-legged ...
EGT35769      398 IKA---------------MPR--DgisdadekeFLDRVRVhG--GGDYYfgegRQLSAII-----NkTPp---KTL-ANY 449  Caenorhabditi...
CAP25066      978 MRA---------------LPR--QkmtseeekkFFSKIRVhG--GGEYFfgekRELAQIA-----ItTPk---TVL-ANY 1029 Caenorhabditi...
XP_003109896  339 MRA---------------LPR--EatseemkedFIKKIRVhG--GGEYFfgeeRKVRRLAri--aTkTPk---KTL-ANY 393  Caenorhabditi...
O16636        276 LKA--------------LARH--Gtsee-deekLLERVTVhG--AGEYFfgenRELARIA-----TeTPk---SAL-ANY 327  Caenorhabditi...
EGT33814      384 LSR---------------LVG--Enl------sHSEPIALkT--GTQWI----PILSAIVeklkqTrSGv---AVL-KNY 430  Caenorhabditi...
PDM62546      372 LRG--------------FMAV--Ps-------sLSTKIIV-Ap-GRAWL----YRLLDLLk----TyDNpegqTII-KDY 417  Pristionchus ...
EGT34392      310 IKSlinpakkeetwkkvMG-----------------KVRV-H--IPGYFanqtSNLETIL-----KtTPk---RVL-ANY 360  Caenorhabditi...
XP_003110234  379 VSNs------------gIFSQ--T---------KQARLAVfQhfHEVFF----Q-LSNIL-------QN----RIIaVDF 419  Caenorhabditi...
3DWB_A        294 MIWNLVR-KTSSF--LDQRFQDA---DE--KFMEVMYGTKKtsL-PR-WK-FC-VSD-TENN-LGFALG--PMFV-KATF 356 
XP_002416301  283 VGWRVVK-E------LASEA------SF--QVGVALAGTDY--VfS--EQ-RC-FAT-VRDS-VHFALTtpTIL--SA-- 335  black-legged ...
EGT35769      450 IVFRQLI-DLSMYfhHKDQPSQK-------RYLG---YEN--------LVaFC-QYQ-LASF-FPMPAT--NVLTeKSEY 505  Caenorhabditi...
CAP25066     1030 LVVRQII-DVALY--YYDKDQPR---QG--KFYN---HENQ--Q--V----FC-VDQ-L-AFfFPMPSM--NVFIeTSGY 1085 Caenorhabditi...
XP_003109896  394 IVIRQII-DVALY--YYDKDLPK---QG--KYYK---KGSL--Q--N----FC-STL-MF-NfFPIPSM--NIFIeQSEY 449  Caenorhabditi...
O16636        328 LVVRQLI-DVALY--FYDKDQPR---QN--KFYN---HVDQ--Q--S----FC-ATQ-VASF-FPMPSM--NVFIeSSQF 383  Caenorhabditi...
EGT33814      431 VKWKTIM-FHLAY--ASPKCRDGl-lWMavSLYS---GAAS--Q--R-KE-FCvLRL--SGI-FPLSLP--SIL--RKID 490  Caenorhabditi...
PDM62546      418 IKFKQFI-MLYIH--SGKLTVHKspeGL--EILDLLYNGNT--D--R-NV-FC-LKR-VG---MSNQLG--LVSL-LERF 478  Pristionchus ...
EGT34392      361 LIMIYIRsEILKI-------KKV--------------GESH--V-------HC-ARAaIS-T-LPLAAL--RVIV-RNHF 404  Caenorhabditi...
XP_003110234  420 LIYIFIDdAFQRY----ENFKNE-----------------------RkQQ-DC-AQVvID-N-LPHAST--RVFV-RNYL 465  Caenorhabditi...
3DWB_A        357 ----A-EDS---KSIATEIILEIKKAFEESLSTLKWM-DEETRKSAKEKADAIYNMIGYP 407 
XP_002416301  336 ----S-EESt--RSFIANTAVAVRRSYMDKIRQNHWM-DFPTKSRALQKARFMKLLDGYP 387  black-legged tick
EGT35769      506 ----N-FDNw--K-IAAEMFNNIKKEYAEIFNGNTYL-EPSIKELYLRKLETLSGKFGEK 556  Caenorhabditis brenneri
CAP25066     1086 ----KmENL---K-IIERIFKEIKLEYTQLFQENQWL-EPKIREFFIRKLNAISGKFGFQ 1136 Caenorhabditis briggsae
XP_003109896  450 ----DmENL---K-MMERFLNELKEEYEGIFNENQYL-EPEIRSFLKKKLKGISARFGYP 500  Caenorhabditis remanei
O16636        384 ----KiENL---K-VIEEMFVKIKAEYEQIFTENEYL-ELEIREFLIRKLNAIDGKFGLD 434  Caenorhabditis elegans
EGT33814      491 g--iD-HTEknvK-AVQDVADRIQEKYEEMVKSSNLFsDSETRQNVVDKVNNMTKFIGFP 546  Caenorhabditis brenneri
PDM62546      479 fgvrL-QEN---IKYAKEIVEATRKEYIDTLRTSAVV-DNRDRPAMIEKAENIRIRLGIP 533  Pristionchus pacificus
EGT34392      405 ----D-KEN---IDIASKMVEEVRQSFIEMIQESDWL-NEETKRNAIRKATMMRKMVGYP 455  Caenorhabditis brenneri
XP_003110234  466 ----N-KKNl--K-SVSDLVESEKSNFIEMIKESKQL-HENSKKKAVVKVEKMKTVIGYP 516  Caenorhabditis remanei
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