Conserved Protein Domain Family
Epiglycanin_TR

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pfam05647: Epiglycanin_TR 
Tandem-repeating region of mucin, epiglycanin-like
The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).
Statistics
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PSSM-Id: 398978
Aligned: 12 rows
Threshold Bit Score: 32.6303
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_025274941   84 NTETRITSNGTSTISNTKSSTISGGTSTGVNIGFSTTSGRT---------------SIASNTQSSVTSNGTSTAFSTGSS 148  dingo
O17084         11 GPSSTVTNSASSETPCNSETQTSDGTSPMTVSSDSTTAGPS---------------STATNSASSETPCNSETQTSDGTS 75   Caenorhabditi...
XP_011218805  290 STGSSTTSGRISIVTKTGPSVTSSVSSTTTDPRSTPTSRGS---------------STPMNTGSSESSGGTSIASSTRSS 354  giant panda
ELK11190      270 STGFSTSSNETSTVSNIGSSVSPSETSTTSSTGSSVTPNGT---------------STPANPGSSTIPSGTSITSSIGFS 334  black flying fox
1_pfamImport    2 STESSVTSSGASTTSSTESSTASGGTSTVSNLGSSVTSSGT---------------SIAANTASSATTGVFSTHSPTGTH 66  
6_pfamImport    1 -NEHSTISGGMSTLVNTGFSTTSGGTSIVSNTGSSVTSSGT---------------STASSTESSVTSSGASTTSSTESS 64  
XP_011218805  189 DTQSSTVSGGTSTAANGESSVTSSGSSTTSDTQSSTASGGT---------------NTGSNGESSVTSSGSSTTSDTQSS 253  giant panda
XP_025274941  322 NTGFNMTSSGAWTVANTGSSVTSRGTSVPSDIGSNVTSSGT---------------STAANIASGATTGASGTFSPTGTH 386  dingo
XP_011956393  287 STGSSMTSGGASTTSDTGSSGTSGGSSTTSDTGSSTASSGT---------------STASKTGSSATTGGSDTSFPTGTQ 351  sheep
XP_011956393  167 DTGSSVTSGGASTTSDTGSSVTSGGASTTSDTGSSVTSGGA---------------STTSDTGSSVTSGGASTTSDTGSS 231  sheep
XP_011956393   33 NNESSPTSSEPTTAT-TGSSATSSETSIAANTAPSTTHGSP---------------TTATNAGSQETSSGSSTTSSTGPT 96   sheep
XP_018884259  527 NSESSTPSSGASTATNSESSTPSSGASTATNSESSTPSSGAgtatnsessttssgaSTATNSGSSVTSAGSGTAALTGMH 606  western lowla...
XP_025274941  149 TT 150  dingo
O17084         76 TM 77   Caenorhabditis elegans
XP_011218805  355 TT 356  giant panda
ELK11190      335 MT 336  black flying fox
1_pfamImport   67 TT 68  
6_pfamImport   65 TA 66  
XP_011218805  254 Ta 255  giant panda
XP_025274941  387 TT 388  dingo
XP_011956393  352 TT 353  sheep
XP_011956393  232 VT 233  sheep
XP_011956393   97 MT 98   sheep
XP_018884259  607 TT 608  western lowland gorilla
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