Conserved Protein Domain Family
Leg1

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pfam05612: Leg1 
Leg1
Protein liver-enriched gene 1 (Leg1) has been suggested to function as a novel secreted regulator for the liver development.
Statistics
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PSSM-Id: 398957
Aligned: 5 rows
Threshold Bit Score: 426.618
Threshold Setting Gi: 74853052
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4QRF7        29 GLPIqwrKAPSDLSHLPISntgvqvNPWVYSQRMTMLKMVINATNayMSSMGPGEQENPLWSLPLQLGWKLKSGRLADPT 108 zebrafish
Q54KF5        26 KKEI---KISNDKINLPTY------NPWIFQDRFNLYSILINSTN--IPVFGEDNSNNCLHGLQLQFEWQNRSGRLEINQ 94  Dictyostelium d...
XP_007259743  26 GLPIlwgSAPSMLSELPQAdgvvkpDPFDYLQRMAMYRLMINATDpyMSSMGPAANENPLWGLPLQLGWKLRSGRLVDPT 105 Mexican tetra
XP_003440678  27 GAPIlwaQTASQVTELPMHdgillpDPWNYLHRMSLYRLMIAATDpfMGSMGTNATDSPLWGLPLQLGWMLTSGRLADPT 106 Nile tilapia
XP_003971659  27 GAPIlwaQTFSQLSELPMLngtvtpNPWNYLHRMSLIRLTIAATDtnMGFIGSSGTASPLWGLPLQLAWMLTSGRLADPT 106 torafugu
Q4QRF7       109 pdSSstcgseasdpvcISPLSFFGCVNYYLSVLPFLAAVETGVVSsgghqmLIQVPAEVAQDYCSSYSDCSTkhpNTMAK 188 zebrafish
Q54KF5        95 --GH------------VNTKSWWGDMNYYLSIIPYLSAMKMGLVP------VVEIVSINDQRFCSTYEDCDQ---EVLNN 151 Dictyostelium d...
XP_007259743 106 --GVstcgqesfspvcIATSSWWGCVNYHLSVLPFLAAVEAGVVGdgqaqvEIQVPAEVAAVYCSS--NCSSthpDAMNK 181 Mexican tetra
XP_003440678 107 --GAttcgle-aeplcISTQSWWACVNYFASVLPFLSAAQQGFMGaga-qvQMQVPAGV-QDYCTTYADCKAkypDAMSK 181 Nile tilapia
XP_003971659 107 --GAstcgvqtgdpmcISTQSWWGCVNYFSSVLPFLSAVQQGFMGaev-qvQLLLPEG--EDFCATYADCAArfpDAMSK 181 torafugu
Q4QRF7       189 WHLFFQSLRQVSQSKESDFNKKdsILGLMWAAEEESIQTASGACTERQK--------LYSSPEVSFQQSSVNLGAFISAA 260 zebrafish
Q54KF5       152 WDNFFQQIINIRNNGSEGDDQQ--LLKFMWTAHIGSIDKATKLFTDSLL--------LLPKNELRFGNGWAHFVDVIATV 221 Dictyostelium d...
XP_007259743 182 WLTFFQSLKTISASEVSDEEKRdqILGLMWSAQLASLDTAASTCADKKA--------LYSGKEVAYSESWLSSAQYVGAA 253 Mexican tetra
XP_003440678 182 WDAFFQGLKTTSESLLPDDVKKdtILGVYWDAQMAS-TYASAACNARQS--------HYSSVEVSFAQSWLNSAEYVAAA 252 Nile tilapia
XP_003971659 182 WDAFYQGLKALVDSPLPEGVKKdtLLGLYWAAQMAT---------SAGSsacstrqrHYSSAETSFANSWVSTAEYVAAA 252 torafugu
Q4QRF7       261 HYHASIERSGKFMSHLPSRVLQEADSPP-NIADLSTEENHALYMlswMNSINQLLGGSLVdlWRKAMC---SAQAREKGQ 336 zebrafish
Q54KF5       222 NFNTNYSTVYHLGQQLPPIMLNSNDTHPsSIESFTKEQRNVVLT---MYEINDLSSNNLV--WNSFMYllkKMTKNEICR 296 Dictyostelium d...
XP_007259743 254 HFSSGLDRSVQFMRPLPSRVLLQTDIPP-NIADLSTEENHTLYIfgwMTTANKLLGGSLTlmWQKAMC---TSAAREKGR 329 Mexican tetra
XP_003440678 253 RFQANMEKALLFLSPLPSRILQEGDSAP-NIVGLTAEENHTLYIfswMKTIDSLLGGTLLrlWKGAMC---SVNTRQKGA 328 Nile tilapia
XP_003971659 253 HFQSSLENSAMFIKNLPGRVLKSDDRAP-NIADLSQEENHTLSIfswMSTINNILGGSLVrmWKSAMC---SVTTREKGR 328 torafugu
Q4QRF7       337 AFLD---DLILDPKFPGssLWSIICVMST 362 zebrafish
Q54KF5       297 NLINneiNIFLNSPVPT--IIEILFDILT 323 Dictyostelium discoideum
XP_007259743 330 TLLN---DLLFNPQFATssMLSILSEMIT 355 Mexican tetra
XP_003440678 329 QVLE---QLLLNPSFATstFLSIITEMTT 354 Nile tilapia
XP_003971659 329 EMLG---QLLLNPSFATssLLTIITETSr 354 torafugu
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