Conserved Protein Domain Family
zf-His_Me_endon

?
pfam05551: zf-His_Me_endon 
Zinc-binding loop region of homing endonuclease
This domain is the short zinc-binding loops region of a number of much longer chain homing endonucleases. Such loops are probably stabilized by the zinc and may be viewed as small but separate domains. The common structural feature of these domains is that at least three zinc ligands lie very close to each other in the sequence and are not incorporated into regular secondary structural elements. The biological roles played by these small zinc-binding domains are presently unknown.
Statistics
?
PSSM-Id: 368495
Aligned: 11 rows
Threshold Bit Score: 94.1622
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EDN95828 133 SALVTRTEKDGKINESVKLREGRNankdrpg------viltkgSRTKVYVYHIvALVTAIRNPGPRLtpdllrsvsqeks 206
Q8X1S1   120 IGWCRSSVLKPNKQDGYIQVSFKG-------------------ANKIALLHEL-VLWADGLQCNPIRn------------ 167 Beauveria bassiana
Q966Z7    22 GCWTLRKIRR--------TKTVKKgtmtyppgfktgkklqykiEGRYVVAHRV-WFYATEESREVLGr------------ 80  Naegleria sp. NG874
Q2TSV0    40 SCY--RTNYAVVKPAGYVQLRL---------------------HGRKYYGHVVaCIFNAGRVPVE--------------- 81  laver
Q7Z9J1   146 ACWTSPDKQPSEPGKPYRKLNWRNtnhpn---------rpsekIGHVFYAHHI-GAVAAGYGnhlsli----------sg 205 Neoscytalidium dimi...
Q6W364   163 SCW--AAKQESGHRNGYIKLNLRNtvgp-----------tgqkIGVSPWAHQL-AAVAAGQGsqlpl------------t 216 Capronia pilosella
BAF74739  88 ECGIVKCDYALDLCRGYNKTYQVSe------------------RNVHLSFHKL-RYMATHNSFAQNS------------- 135
O46338   115 ECLIGAANKT---KSGF-KVRFMNn------------------KGSDSYVHHA-SSRLLIRIVNCIHslemletvssskr 171 Naegleria sp. NG055
ABD62811 122 ECLLGASNKS---KSGF-KCSFLSd------------------KGSDGYVHHV-SILANSRSSDPIHklalikkvsqrkk 178
ABF71483 123 GCW--ESNLAGRPNSGYQRVNLRNtvin------------grkAEVQIYLHQL-TLIADNRRGelmaav---------le 178
Q8TGE3    33 NCW--KPTTKPTHRNGYCQINLRHtllda----------sdkkIGRCIYLHHL-SLVAANKAheltrl----------na 89  Coemansia mojavensis
EDN95828 207 eknAQTILHLCGHHWCLTPGHLAVGSKVLNDEQTACHgilQSAKSLEEHDSIQKNGSS-----LASP--AGKVWTERNKI 279
Q8X1S1   168 ---GQHISHLCANPRCMTLGHLVVEDAAINQSRKGCGk--IKACRHAGCSKWVYFCDH-----KPRC--IRFVEGFASWK 235 Beauveria bassiana
Q966Z7    81 --pNATVSHRCHNEHCLNPDHLVVEPLQVNQSRNTCT----------------GVCLH-----RPKC--IRDGNQADKTK 135 Naegleria sp. NG874
Q2TSV0    82 ---GEQASHRCHRGACVNPQHLVFETERVNKTRQYCDhfkDHPD---------HNCLH-----QPQC--IRVHGNIDTPL 142 laver
Q7Z9J1   206 ahaAYNVSHLCGNGECFNPDHLVIETAGLNQRRKTCQ---GHAQVRLPNGSVYHPCQHgteehAKLC--ILPLRRAPLGR 280 Neoscytalidium dimi...
Q6W364   217 tkgEYHVSHLCHNAGCINPDHVIIEPAWINEFRKFCA---KAWAVRFPDGSFLDPCRChv-dgSPRC--LIPTWYKPDGA 290 Capronia pilosella
BAF74739 136 ---GKEHTHICGDTNCCRPSHVIYAPKGTNISRTNCPg-yVRWKDNNNKEIFYKVCKH-----DPPCrvVTDFHYLDRLP 206
O46338   172 dhdARTISHLCGNGGCARPGHLRIEKKSVNDERCHCHfllRRSQSLHQSEMIRMACPH-----TPRC--FVNIYKINKPY 244 Naegleria sp. NG055
ABD62811 179 eknAYSVSHLCGNGGCARPGHIIIEPKTVNDERVACHrflRSCKCKWDARVIRRLCPH-----KPKC--FVNTYVGIKAY 251
ABF71483 179 selAMECSHLCHNGRCFRPSHLVVEPRAENKERQTCN---GHFIIK-HGGMTYNPCRHgfgslRRDC--LLPVKVVPDGY 252
Q8TGE3    90 gkkRLQVSHLCHRGWCFNPEHLVVESQRLNAKRNNCK---GNNIFITNNGVTINPCPHgkngiRPSC--ILPIKHISKQA 164 Coemansia mojavensis
EDN95828 280 H 280
Q8X1S1   236 E 236 Beauveria bassiana
Q966Z7   136 F 136 Naegleria sp. NG874
Q2TSV0   143 E 143 laver
Q7Z9J1   281 Q 281 Neoscytalidium dimidiatum
Q6W364   291 A 291 Capronia pilosella
BAF74739 207 H 207
O46338   245 Y 245 Naegleria sp. NG055
ABD62811 252 Y 252
ABF71483 253 H 253
Q8TGE3   165 N 165 Coemansia mojavensis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap