Conserved Protein Domain Family
Ran-binding

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pfam05508: Ran-binding 
RanGTP-binding protein
The small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle and nuclear envelope formation during mitosis in higher eukaryotes. The S. cerevisiae ORF YGL164c encoding a novel RanGTP-binding protein, termed Yrb30p was identified. The protein competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p) and is, like Yrb1p, able to form trimeric complexes with RanGTP and some of the karyopherins.
Statistics
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PSSM-Id: 398908
Aligned: 78 rows
Threshold Bit Score: 292.875
Threshold Setting Gi: 367003936
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003718619   1 MDAFLTRLGAQAMN----MAIRSGIALTSTYAVQQCARLLKTVd-DKSiRTELRLLQQELNERIKIISPAIDLIEFKAGR 75  Pyricularia ory...
XP_001482576   1 MDQLLARAGSQAVT----FAIRLGITFASGYAVRTVTKFLDKIpeSEK--KKILDKRTKIRIKTDILGQAMDLIRLAAVR 74  Meyerozyma guil...
EGV63282       1 MDDFITKASSQAVS----FAIRSGISLASGYAIRTVTKFVDKIpeKDK--AQLNNKIHRVKLQINIVSPSIELIKSMNAG 74  Yamadazyma tenu...
XP_002172067   1 MDQLLTKVTSSAATyataFAIRSGIQWAGSLAARRLSKYIHKTtsERS-QYSLELVKSRLEQKIRAITPAIDLIELIAAR 79  Schizosaccharom...
EPY49687       1 MDQIFTKVTASAATyataYAIRTGVNWAGSLAAKRLTKFIQQSapESS-QYNLDLVKSRLEQKILAITPAVDLIELIAAR 79  Schizosaccharom...
Q09721         1 MDQVLSKVTTTAATyataYAVRTGLQLAGSLVAKRFSKYIQTSapKSS-QFNLELVKSRLEQKIQAITPAVDLIQLVAAR 79  Schizosaccharom...
CCG84378       1 MDALLASAARYSAG----LAIRSGISIAGGFAIRQVSTYISKVpqNLH-VQELELISKRLDQKIKIVTPAIDLIEIIAAR 75  Taphrina deform...
XP_002172940   1 MDELL-HVASHAATfattFAIKRSISFASKLAIQQVSSYIKKVptDHR--ASLENEKAKLLEIIRVVTPAIELIEIISAT 77  Schizosaccharom...
O94589         1 MDELL-NVASHAATfatnFALKHSISFAGKLAVQQVSSYIKRAsaDDQ--SELESVKTQLLEMIRVVTPAIELIEIMSVG 77  Schizosaccharom...
EPY51322       1 MDELF-HVASHAATfatsFAIKHSISFAGKFAVQQVSSYIKRIpdADR--NELEFMKAKLLEMIRVVTPAIELIDIMSSS 77  Schizosaccharom...
XP_003718619  76 GNVFLENAVPLAKGLRRSIVALGKRLEDVACAEEEAQQhareararprtPESQAAELRSIICEMKTLLGRIERDAHMLQF 155 Pyricularia ory...
XP_001482576  75 GNTSLEPSLELIEAVTSEIERFETKMSSITETLS---------------SLNEKESVIEVNRCMDNLLTQLDEAIPLLQL 139 Meyerozyma guil...
EGV63282      75 GFSSLQSCNELIDQMTQSFREFDDMVEKWSDQLS---------------NSNTGDVIKQVNKQLDGLIDMIDQTVPLLNL 139 Yamadazyma tenu...
XP_002172067  80 GNSSLQNLVPLIIRLRGNIDNFNDTLAEYTNMSPPSS------------EQAASARCDEVQKSCEQLLSSIEQAIPLINL 147 Schizosaccharom...
EPY49687      80 GNSSLQNLVPLIQRLRDHIDEFSEYVNEKDSLSPD--------------EENLEEASKDIYTSCESLLKEIEQTIPLINL 145 Schizosaccharom...
Q09721        80 GNSSLQNLVPLIIRLRDHIDDFLEFIDYEASGSEKKS------------PEKADEASEKIFRRCEVLLREIEETIPLINL 147 Schizosaccharom...
CCG84378      76 GNTTLNSTVQLTVSLRNDINAFGQRMADVMSEEPSP-------------HTGSKEATRKVLDDMKSLLARIEDAVPLISL 142 Taphrina deform...
XP_002172940  78 GNPSFASTRELVETLRSDITHFIQTISGAFAMEEDK-------------PTTEKRTTATVLREIETLLLCIQDAIPLLNL 144 Schizosaccharom...
O94589        78 ENENFKSTKQLVDSLHADIEQFTKHVLSAAHSEFPPSSe---------kETLQKNVDTSILREMKTLLLKINDAVPLLNL 148 Schizosaccharom...
EPY51322      78 GNQSLQSTRQLVDALRSDIEKFSVHILGVASSDSGEEAs---------nPKRAEETKGKVLQEIKTLLLRIQDAIPLLNL 148 Schizosaccharom...
XP_003718619 156 AISASGENLSTSLPPGVSPSRLMQASTFLSIGDTQFASDPY-GPVQIGPSFTLSLYLLFMGHSkTETRARPAqgnaltti 234 Pyricularia ory...
XP_001482576 140 SIATSGTTMKTSLSPSVSPGRLLQASSLVAKA------NESkLPCNVGPVFDLVYYSVFYNPSrLKYIDHEDnkkvdv-- 211 Meyerozyma guil...
EGV63282     140 CIVTSGINLNRDLSEEISINKLIEASNIILGSr---------DSTNTGPVFDLTFFSVFYNPSrLKYIEHESgnq----- 205 Yamadazyma tenu...
XP_002172067 148 ALTTSGVSLSSTVTDTISPSRLLQAASFLELADEKFKSKSS-ANIRVGPPFDMILYTIFSGHSrGATANDDAi------- 219 Schizosaccharom...
EPY49687     146 SLTTSGVTLSSALKESLSPSRLLQAQAFLELSDKQFEETQ--KDVQIGPKFVLTLYNTFHRSNqSDGPSD---------- 213 Schizosaccharom...
Q09721       148 SLTTAGITLNTALSNTISPSRLLQAQCFLELSDKRFE-ESH-TEIQIGPKFTVVLYTSFSQPSkSDGPLD---------- 215 Schizosaccharom...
CCG84378     143 ALTTSGANLSATLPDTVSPSRLLQASAFLQQADKQFDTKSL-QEVQVGPSFSLKLYTIFEGHSrQSQDSNVTn------- 214 Taphrina deform...
XP_002172940 145 SLTTSGVSISSSLPQTTSFSNLLLANSYMRKCNLKFNG----EPCLLGPKFNIKLYTIFEGHAnSKYLSKDTv------- 213 Schizosaccharom...
O94589       149 SITTSGASISSSLPKSTSFSQLLRANSYIYRANVAFTGN---EPLQVGPTFFLRTYKIIDNHAkSGYISNDLv------- 218 Schizosaccharom...
EPY51322     149 SITTSGLSISSSLPKSTNFSQLFKANSFVLHSNLSFTGE---KPLQVGPTFRLRTYKIFESHAqSKFLNHDSi------- 218 Schizosaccharom...
XP_003718619 235 nsgnpvnnstdqvdspygfqegeRKPLWQEVVHKARVRLCRVPPDWKFdrergyiplplpqspnrdqrahssysytaknE 314 Pyricularia ory...
XP_001482576 212 -----------------akdddlLAISWKEEYSRALVRIISnn----------------------------------ksS 240 Meyerozyma guil...
EGV63282     206 --------------------edeTPITWKEEFARAKVSIKSt------------------------------------gN 229 Yamadazyma tenu...
XP_002172067 220 -------------------------VSWKETYAKAKITVERkrh--------------------------------ansK 242 Schizosaccharom...
EPY49687     214 -------------------------VSWKEEYPKCSVYVKRfvs---------------------------------eeR 235 Schizosaccharom...
Q09721       216 -------------------------VRWQETFAKSDLYIKRvvs--------------------------------asqK 238 Schizosaccharom...
CCG84378     215 -------------------------ITWQETYARSILEVIRMPMEADIkhdesy-------------------ardhklN 250 Taphrina deform...
XP_002172940 214 --------------------------LWKESMPLGHAYIRRvtsssq---------------------------kfeerM 240 Schizosaccharom...
O94589       219 --------------------------MWKEEMPVCIAKMFRMPPQRLksk---------------------------dtV 245 Schizosaccharom...
EPY51322     219 --------------------------IWQEDCSVCVAKVFRVPPQQShnk---------------------------nsL 245 Schizosaccharom...
XP_003718619 315 FSYHLEIIEDLDDGRLHDG------EGSFFDdipmagiresIPVHHLSKIFYTNTGRILNIgqelaPDNSPALLLKRDST 388 Pyricularia ory...
XP_001482576 241 FQYSLEIREDHNDGRYHDE------KPKVVV----------YDVKSIMRMFFSASGKLLKLe----SRSAPVLMFKLVDK 300 Meyerozyma guil...
EGV63282     230 FSYDLNIIEDFDDDRYHEG------APKTKV----------VKVNDVRKIFFSRSGKLLRLd----NNDSAVLILKLDDE 289 Yamadazyma tenu...
XP_002172067 243 HAYCITLNEDLNDGRYHDEia---gMPSPTKgaflqgrkrtIPVSQVRKISYSLSGQLLDLe----QARTPVLAIQLSKP 315 Schizosaccharom...
EPY49687     236 FRYVLIIEEDLNDGRYHEEllgkdlSSSisgn------tieYPINCMSILCYTVSGKLLDIp----QSRSPVLAVQLMQT 305 Schizosaccharom...
Q09721       239 FSYVICIDEDLNDGRYHEEtv---gKPTsapvf---gkkleISLQRMSLLCYTVSGRLLNIs----QAKSPVLALQLTSI 308 Schizosaccharom...
CCG84378     251 YLYHFRVTENLDDGRYHEEler-stYKRDSHgfirg-asrdIPVHNIARLFFSASGRLLNId----EARTPVLVLKINHG 324 Taphrina deform...
XP_002172940 241 LAYELCLDQSFDDGMYHDDd----eKALKIR----------IPLYNIQSLFYSLSGKILRLd----NVSSPVLLLKYIIQ 302 Schizosaccharom...
O94589       246 LAYALSLKQSFDDDRYHDEd----eTPVTKT----------ISLNDVRTLFFSLSGKLLRLd----DVQTPVLLLKYADD 307 Schizosaccharom...
EPY51322     246 LSYKLSLVQSFDDNRYHEEd----eVPMTKD----------ILLSTIQTLFYSVSGKLLRLd----EVTTPVILLKYKDN 307 Schizosaccharom...
XP_003718619 389 A 389 Pyricularia oryzae 70-15
XP_001482576 301 D 301 Meyerozyma guilliermondii ATCC 6260
EGV63282     290 Y 290 Yamadazyma tenuis ATCC 10573
XP_002172067 316 S 316 Schizosaccharomyces japonicus yFS275
EPY49687     306 F 306 Schizosaccharomyces cryophilus OY26
Q09721       309 K 309 Schizosaccharomyces pombe 972h-
CCG84378     325 L 325 Taphrina deformans PYCC 5710
XP_002172940 303 S 303 Schizosaccharomyces japonicus yFS275
O94589       308 E 308 Schizosaccharomyces pombe 972h-
EPY51322     308 P 308 Schizosaccharomyces cryophilus OY26
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