Conserved Protein Domain Family
Destabilase

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pfam05497: Destabilase 
Destabilase
Destabilase is an endo-epsilon(gamma-Glu)-Lys isopeptidase, which cleaves isopeptide bonds formed by transglutaminase (Factor XIIIa) between glutamine gamma-carboxamide and the epsilon-amino group of lysine.
Statistics
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PSSM-Id: 398901
Aligned: 48 rows
Threshold Bit Score: 121.249
Threshold Setting Gi: 268552735
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001156290  32 TEKCIGCMCEASSgcNQ-TLECMEqnevKYCGVFLLSDVYWQDAGTPvlqgdd-pnrigAFERCVRDPYCAARAVNQYIQ 109 pea aphid
XP_015789146 344 DEHCLNCICQASSgcNItRTQCPNg---sNCGPYQIDLSYIKEAGGDsma-------dnTFEDCANDKECSENIVRVYMK 413 two-spotted spi...
XP_788343     33 PADCLKCICIVESkcKMpAHVCHMdvgsLSCGPYQIKDDYWNDARMKggd------lmgSWRKCTADMGCSSETVQGYMA 106 purple sea urchin
EEN58606      24 yDECLDCICKVEStcRMpSPLCHWdvgsDSCGPYQIKYAYWQDAQLHggn------lmgDWRTCARSFRCSRRAVRGYMD 97  Florida lancelet
EEN49935      24 PDACMNCICYVQSgcHMpDPICHMdggsLSCGPFQIQQRYWEDARRKggp------lmnDWKTCAASWTCSRDAVNGYME 97  Florida lancelet
EEN49934      25 PDACMNCICYVQSgcHMpDPICHMdggsLSCGPFQIQQRYWEDARRKggplmnvlspfpDYQRCAASWACSRQALDAYLQ 104 Florida lancelet
XP_792095     22 pYDCLNCICEVESncAMpNPPCRMdvgsLSCGPFQIKQAYWTDAKRHggy------lmgSWSACTANWGCSRNAVQAYMT 95  purple sea urchin
PDM77849      24 aTDCLKCICNKESgcK--PVGCHMdvgsLSCGYYQIKSPYYQDCGQPgkkag--edtdtAWKRCADDYNCSSGCVQAYVN 99  Pristionchus pa...
O02119        17 SSDCLQCICKKESecK--PVGCNDdvgsLSCGYYQIKLSYYKDCGQPgkrag--esveaAWRRCSDELDCASTCVQSYYN 92  Caenorhabditis ...
Q19698        17 SADCLHCICMRESgcK--PIGCHMdvgsLSCGYYQIKIGYYEDCGQPtkkag--etteaAWKRCADDLNCATTCVENYYN 92  Caenorhabditis ...
NP_001156290 110 RYAKDCNKDRVLSCDDYVRLHYFGEANCERPI----SS-LPYYRVFRNC 153 pea aphid
XP_015789146 414 RNVMDCNEDEILDCTDFALVHKLGRSHCRQARevesFLnSAYWAEFQAC 462 two-spotted spider mite
XP_788343    107 RYAVFSRLEHQPTCEDFARIHNGGPNGYNKTSt------LKYWSRVKEC 149 purple sea urchin
EEN58606      98 RYATRARLGRQPTCQDYARIHNGGPNGYMYDSt------LSYWRLVQAC 140 Florida lancelet
EEN49935      98 RYAVPSRLGHGPTCEDFSRIHNGGPNGLKNPAt------IAYWGRVKKC 140 Florida lancelet
EEN49934     105 LYAVSSRLGHSPTCQDFARIHHEGPNGFKSAAt------IEYWEKVKKC 147 Florida lancelet
XP_792095     96 RYATVGRLGHTPRCEDFARIHNGGPNGFQKSGt------VAYWNKVRAC 138 purple sea urchin
PDM77849     100 RYKSKCP--NKGSCEQMSRLHNGGPNGCNNSNt------VGYWNSIKSC 140 Pristionchus pacificus
O02119        93 RYKKQCAGTGQGACEIMARNHNGGPRGCKKSAt------LGYWNGIKGl 135 Caenorhabditis elegans
Q19698        93 RYKSQCNGLGMGACQIMSRNHNGGPRGCHNANt------LAYWNGVKSC 135 Caenorhabditis elegans
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